The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy
Open accessAbstract
The use of photodynamic therapy (PDT) against cancer has received increasing attention over recent years. However, the application of the currently approved photosensitizers (PSs) is limited by their poor aqueous solubility, aggregation, photobleaching and slow clearance from the body. To overcome these limitations, there is a need for the development of new classes of PSs with ruthenium(II) polypyridine complexes currently gaining momentum. However, these compounds generally lack significant absorption in the biological spectral window, limiting their application to treat deep-seated or large tumors. To overcome this drawback, ruthenium(II) polypyridine complexes designed in silico with ( E , E ′)-4,4′-bisstyryl-2,2′-bipyridine ligands show impressive 1- and 2-Photon absorption up to a magnitude higher than the ones published so far. While nontoxic in the dark, these compounds are phototoxic in various 2D monolayer cells, 3D multicellular tumor spheroids and are able to eradicate a multiresistant tumor inside a mouse model upon clinically relevant 1-Photon and 2-Photon excitation.
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Cites
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Sheldrick, G. M. (2015) · Acta Crystallographica Section C Structural Chemistry · doi:10.1107/s2053229614024218 · Cited by 43,982
OLEX2 : a complete structure solution, refinement and analysis program
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SHELXT – Integrated space-group and crystal-structure determination
Sheldrick, G. M. (2015) · Acta Crystallographica Section A Foundations and Advances · doi:10.1107/s2053273314026370 · Cited by 29,831
Spheroid-based drug screen: Considerations and practical approach
Friedrich, J., Seidel, C., Ebner, R., & Kunz-Schughart, L. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.226 · Cited by 1,742
Cited by
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Metallodrugs in cancer nanomedicine
Peña, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H. W., Metselaar, J. M., Kiessling, F., Pallares, R. M., Wuttke, S., & Lammers, T. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00468a · Cited by 259
Li, C., Pang, Y., Xu, Y., Lu, M., Tu, L., Li, Q., Sharma, A., Guo, Z., Li, X., & Sun, Y. (2023) · Chemical Society Reviews · doi:10.1039/d3cs00227f · Cited by 157
Metadata
- Authors
- Karges, J., Kuang, S., Maschietto, F., Blacque, O., Ciofini, I., Chao, H., & Gasser, G.
- Venue
- Nature Communications
- Published
- 2020-06-26
- Volume
- 11
- Issue
- 1
- Pages
- 3262-3262
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3037409366
- Cited by
- 284
- References
- 4
- FWCI
- 21.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- Karges, J., Kuang, S., Maschietto, F., Blacque, O., Ciofini, I., Chao, H., & Gasser, G. (2020). Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy. Nature Communications. https://doi.org/10.1038/s41467-020-16993-0
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