Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Barski, Michał S.; Minnell, Jordan J.; Hodakova, Zuzana; Pye, Valerie E.; Nans, Andrea; Cherepanov, Peter; Maertens, Goedele N.

doi:10.1038/s41467-020-18874-y

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus and the most oncogenic pathogen. Many of the ~20 million HTLV-1 infected people will develop severe leukaemia or an ALS-like motor disease, unless a therapy becomes available. A key step in the establishment of infection is the …