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A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
Open accessAbstract
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting the receptor binding domain (RBD) of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient. The CT-P59 mAb potently neutralizes SARS-CoV-2 isolates including the D614G variant without antibody-dependent enhancement effect. Complex crystal structure of CT-P59 Fab/RBD shows that CT-P59 blocks interaction regions of RBD for angiotensin converting enzyme 2 (ACE2) receptor with an orientation that is notably different from previously reported RBD-targeting mAbs. Furthermore, therapeutic effects of CT-P59 are evaluated in three animal models (ferret, hamster, and rhesus monkey), demonstrating a substantial reduction in viral titer along with alleviation of clinical symptoms. Therefore, CT-P59 may be a promising therapeutic candidate for COVID-19.
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Metadata
- Authors
- Kim, C., Ryu, D.-K., Lee, J., Kim, Y.-I., Seo, J.-M., Kim, Y.-G., Jeong, J.-H., Kim, M., Kim, J.-I., Kim, P., Bae, J. S., Shim, E. Y., Lee, M. S., Kim, M. S., Noh, H., Park, G.-S., Park, J. S., Son, D., An, Y., Lee, J. N., Kwon, K.-S., Lee, J.-Y., Lee, H., Yang, J.-S., Kim, K.-C., Kim, S. S., Woo, H.-M., Kim, J.-W., Park, M.-S., Yu, K.-M., Kim, S.-M., Kim, E.-H., Park, S.-J., Jeong, S. T., Yu, C. H., Song, Y., Gu, S. H., Oh, H., Koo, B.-S., Hong, J. J., Ryu, C.-M., Park, W. B., Oh, M.-D., Choi, Y. K., & Lee, S.-Y.
- Venue
- Nature Communications
- Published
- 2021-01-12
- Volume
- 12
- Issue
- 1
- Pages
- 288-288
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3119881634
- Cited by
- 281
- References
- 51
- FWCI
- 19.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kim, C., Ryu, D.-K., Lee, J., Kim, Y.-I., Seo, J.-M., Kim, Y.-G., Jeong, J.-H., Kim, M., Kim, J.-I., Kim, P., Bae, J. S., Shim, E. Y., Lee, M. S., Kim, M. S., Noh, H., Park, G.-S., Park, J. S., Son, D., An, Y., . . . Lee, S.-Y. (2021). A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein. Nature Communications. https://doi.org/10.1038/s41467-020-20602-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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