The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
RETRACTED ARTICLE: Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
Open accessAbstract
Smoking has a profound impact on tumor immunity, and nicotine, which is the major addictive component of smoke, is known to promote tumor progression despite being a non-carcinogen. In this study, we demonstrate that chronic exposure of nicotine plays a critical role in the formation of pre-metastatic niche within the lungs by recruiting pro-tumor N2-neutrophils. This pre-metastatic niche promotes the release of STAT3-activated lipocalin 2 (LCN2), a secretory glycoprotein from the N2-neutrophils, and induces mesenchymal-epithelial transition of tumor cells thereby facilitating colonization and metastatic outgrowth. Elevated levels of serum and urine LCN2 is elevated in early-stage breast cancer patients and cancer-free females with smoking history, suggesting that LCN2 serve as a promising prognostic biomarker for predicting increased risk of metastatic disease in female smoker(s). Moreover, natural compound, salidroside effectively abrogates nicotine-induced neutrophil polarization and consequently reduced lung metastasis of hormone receptor-negative breast cancer cells. Our findings suggest a pro-metastatic role of nicotine-induced N2-neutrophils for cancer cell colonization in the lungs and illuminate the therapeutic use of salidroside to enhance the anti-tumor activity of neutrophils in breast cancer patients.
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Cites
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
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Neutrophils in cancer: Neutral no more
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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
Coffelt, S. B., Kersten, K., Doornebal, C. W., Weiden, J., Vrijland, K., Hau, C.-S., Verstegen, N. J. M., Ciampricotti, M., Hawinkels, L. J. A. C., Jonkers, J., et al. (2015) · Nature · doi:10.1038/nature14282 · Cited by 1,703
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
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An Iron Delivery Pathway Mediated by a Lipocalin
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The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
Hiratsuka, S., Watanabe, A., Sakurai, Y., Akashi-Takamura, S., Ishibashi, S., Miyake, K., Shibuya, M., Akira, S., Aburatani, H., & Maru, Y. (2008) · Nature Cell Biology · doi:10.1038/ncb1794 · Cited by 642
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
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Cited by
Breast Cancer—Epidemiology, Classification, Pathogenesis and Treatment (Review of Literature)
Smolarz, B., Nowak, A. Z., & Romanowicz, H. (2022) · Cancers · doi:10.3390/cancers14102569 · Cited by 587
Towards targeting the breast cancer immune microenvironment
Harris, M. A., Savas, P., Virassamy, B., O’Malley, M. M. R., Kay, J., Mueller, S. N., Mackay, L. K., Salgado, R., & Loi, S. (2024) · Nature Reviews Cancer · doi:10.1038/s41568-024-00714-6 · Cited by 363
Is there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review
Lu, F., Verleg, S. M. N. E., Groven, R. V. M., Poeze, M., van Griensven, M., & Blokhuis, T. J. (2024) · Bone · doi:10.1016/j.bone.2024.117021 · Cited by 25
Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway
Liu, R.-H., Ma, T.-F., Yang, Q., Xiao, W.-C., Yin, L., Yin, M., Zhang, J.-S., & Wang, C.-H. (2023) · Cancer Biomarkers · doi:10.3233/cbm-220454 · Cited by 14
Metadata
- Authors
- Tyagi, A., Sharma, S., Wu, K., Wu, S.-Y., Xing, F., Liu, Y., Zhao, D., Deshpande, R. P., D’Agostino, R. B., & Watabe, K.
- Venue
- Nature Communications
- Published
- 2021-01-20
- Volume
- 12
- Issue
- 1
- Pages
- 474-474
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3123371217
- Cited by
- 245
- References
- 10
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- CoChat. (2026). Citation check: RETRACTED ARTICLE: Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. https://app.cochat.ai/papers/10.1038/s41467-020-20733-9
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- Tyagi, A., Sharma, S., Wu, K., Wu, S.-Y., Xing, F., Liu, Y., Zhao, D., Deshpande, R. P., D’Agostino, R. B., & Watabe, K. (2021). RETRACTED ARTICLE: Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nature Communications. https://doi.org/10.1038/s41467-020-20733-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
