Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
Open accessAbstract
Have cancer stem cells MET their match?: Solid tumors have been hypothesized to contain a subset of highly aggressive cells that fuel tumor growth and metastasis. The search is on for drugs that selectively kill or diminish the malignant properties of these tumor-initiating cells (TICs; previously called “cancer stem cells”). Pattabiraman et al. hypothesized that compounds that induce TICs to undergo a phenotypic change called the mesenchymal-to-epithelial transition (MET) would therefore cause TICs to lose their tumor-initiating ability. Indeed, drugs activating the protein kinase A signaling pathway triggered an epigenetic reprogramming of TICs that resulted in the cells acquiring a more benign epithelial-like phenotype. Science , this issue p. 10.1126/science.aad3680
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Cites
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668 · see citing works
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,679 · see citing works
Self-citationRegulatory networks defining EMT during cancer initiation and progression
Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487 · see citing works
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464 · see citing works
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413 · see citing works
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Gupta, P. B., Önder, T. T., Jiang, G., Tao, K. X., Kuperwasser, C., Weinberg, R. A., & Lander, E. S. (2009) · Cell · doi:10.1016/j.cell.2009.06.034 · Cited by 2,386 · see citing works
Self-citationEvolution of the Cancer Stem Cell Model
Kreso, A., & Dick, J. E. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.006 · Cited by 2,212 · see citing works
A restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,096 · see citing works
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
de Rooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A., & Bos, J. L. (1998) · Nature · doi:10.1038/24884 · Cited by 1,970 · see citing works
Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
Li, X., Lewis, M. T., Huang, J., Gutiérrez, C., Osborne, C. K., Wu, M.-F., Hilsenbeck, S. G., Pavlick, A. C., Zhang, X., Chamness, G. C., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn123 · Cited by 1,794 · see citing works
Guy, C. T., Cardiff, R., & Muller, W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.954-961.1992 · Cited by 1,710 · see citing works
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
Morel, A., Lièvre, M., Thomas, C., Hinkal, G., Ansieau, S., & Puisieux, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002888 · Cited by 1,673 · see citing works
Soule, H. D., Maloney, T., Wolman, S. R., Peterson, W., Brenz, R., McGrath, C. M., Russo, J., Pauley, R. J., Jones, R. F., & Brooks, S. C. (1990) · PubMed · Cited by 1,527 · see citing works
Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
Önder, T. T., Gupta, P. B., Mani, S. A., Yang, J., Lander, E. S., & Weinberg, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2938 · Cited by 1,527 · see citing works
Self-citationGuy, C. T., Cardiff, R. D., & Muller, W. J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.954 · Cited by 1,523 · see citing works
Tackling the cancer stem cells — what challenges do they pose?
Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 985 · see citing works
Self-citationSlug and Sox9 Cooperatively Determine the Mammary Stem Cell State
Guo, W., Keckesova, Z., Donaher, J. L., Shibue, T., Tischler, V., Reinhardt, F., Itzkovitz, S., Noske, A., Zürrer‐Härdi, U., Bell, G. W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.008 · Cited by 969 · see citing works
Self-citationSelective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Daigle, S. R., Olhava, E. J., Therkelsen, C. A., Majer, C. R., Sneeringer, C. J., Song, J. J., Johnston, L. D., Scott, M. P., Smith, J. J., Xiao, Y., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.009 · Cited by 926 · see citing works
Cyclic nucleotide research — still expanding after half a century
Beavo, J. A., & Brunton, L. L. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm911 · Cited by 906 · see citing works
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Elenbaas, B., Spirio, L., Koerner, F., Fleming, M. D., Zimonjic, D. B., Donaher, J. L., Popescu, N. C., Hahn, W. C., & Weinberg, R. A. (2001) · Genes & Development · doi:10.1101/gad.828901 · Cited by 878 · see citing works
Self-citationShen, L., Shao, N., Liu, X., & Nestler, E. J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-284 · Cited by 852 · see citing works
Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A
Taskén, K., & Aandahl, E. M. (2004) · Physiological Reviews · doi:10.1152/physrev.00021.2003 · Cited by 776 · see citing works
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
Enserink, J. M., Christensen, A. E., de Rooij, J., van Triest, M. H., Schwede, F., Genieser, H., Døskeland, S. O., Blank, J. L., & Bos, J. L. (2002) · Nature Cell Biology · doi:10.1038/ncb874 · Cited by 704 · see citing works
Johannessen, M., Delghandi, M. P., & Moens, U. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.05.001 · Cited by 592 · see citing works
Gene expression profiling of breast cell lines identifies potential new basal markers
Charafe‐Jauffret, E., Ginestier, C., Monville, F., Finetti, P., Adélaı̈de, J., Cervera, N., Fekairi, S., Xerri, L., Jacquemier, J. D., Birnbaum, D., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209254 · Cited by 571 · see citing works
Cyclic AMP in relation to proliferation of the Epidermal cell: a new view
Green, H. (1978) · Cell · doi:10.1016/0092-8674(78)90265-9 · Cited by 481 · see citing works
Assembly of allosteric macromolecular switches: lessons from PKA
Taylor, S. S., Ilouz, R., Zhang, P., & Kornev, A. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3432 · Cited by 480 · see citing works
Dong, C., Wu, Y., Yao, J., Wang, Y., Yu, Y., Rychahou, P. G., Evers, B. M., & Zhou, B. P. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57349 · Cited by 468 · see citing works
CEAS: <i>cis</i>-regulatory element annotation system
Shin, H., Liu, T., Manrai, A. K., & Liu, X. S. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp479 · Cited by 461 · see citing works
Physiological Substrates of cAMP-Dependent Protein Kinase
Shabb, J. B. (2001) · Chemical Reviews · doi:10.1021/cr000236l · Cited by 373 · see citing works
Ellenrieder, V., Hendler, S. F., Boeck, W., Seufferlein, T., Menke, A., Ruhland, C., Adler, G., & Gress, T. M. (2001) · PubMed · Cited by 361 · see citing works
Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
Tam, W. L., Lu, H., Buikhuisen, J. Y., Soh, B.-S., Lim, E., Reinhardt, F., Wu, Z. J., Krall, J. A., Bierie, B., Guo, W., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.005 · Cited by 322 · see citing works
Self-citationDistinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
Hollestelle, A., Nagel, J. H. A., Smid, M., Lam, S., Elstrodt, F., Wasielewski, M., Ng, S. S., French, P. J., Peeters, J. K., Rozendaal, M. J., et al. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0460-8 · Cited by 296 · see citing works
Chen, C., Yan, W., Hummel, M., Hoffmann, T. K., Gross, M., Kaufmann, A. M., & Albers, A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016466 · Cited by 235 · see citing works
Ahmed, N., Abubaker, K., Findlay, J., & Quinn, M. A. (2010) · Current Cancer Drug Targets · doi:10.2174/156800910791190175 · Cited by 235 · see citing works
Mechanisms of transcriptional repression by histone lysine methylation
Hublitz, P., Albert, M., Hfmpeters, A., Hublitz, P., Albert, M., & Peters, A. H. F. M. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082717ph · Cited by 207 · see citing works
PKA-dependent regulation of the histone lysine demethylase complex PHF2–ARID5B
Baba, A., Ohtake, F., Okuno, Y., Yokota, K., Okada, M., Imai, Y., Ni, M., Meyer, C. A., Igarashi, K., Kanno, J., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2228 · Cited by 200 · see citing works
MEYER, R. B. J., & Miller, J. P. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90228-8 · Cited by 153 · see citing works
Iglesias‐Bartolomé, R., Torres, D., Marone, R., Feng, X., Martı́n, D., Simaan, M., Chen, M., Weinstein, L. S., Taylor, S. S., Molinolo, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3164 · Cited by 147 · see citing works
Quantification of regenerative potential in primary human mammary epithelial cells
Linnemann, J. R., Miura, H., Meixner, L. K., Irmler, M., Kloos, U. J., Hirschi, B., Bartsch, H. S., Sass, S., Beckers, J., Theis, F. J., et al. (2015) · Development · doi:10.1242/dev.123554 · Cited by 143 · see citing works
Orellana, S. A., & McKnight, G. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4726 · Cited by 134 · see citing works
Anastassiou, D., Rumjantseva, V., Cheng, W., Huang, J., Canoll, P., Yamashiro, D. J., & Kandel, J. J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-529 · Cited by 133 · see citing works
Wu, D., Zhau, H. E., Huang, W.-C., Iqbal, S. A., Habib, F. K., Sartor, O. A., Cvitanovic, L., Marshall, F. F., Xu, Z., & Chung, L. W. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210316 · Cited by 132 · see citing works
Taylor‐Papadimitriou, J., Purkis, P. E., & Fentiman, I. S. (1980) · Journal of Cellular Physiology · doi:10.1002/jcp.1041020306 · Cited by 125 · see citing works
Sheng, T., Chi, S., Zhang, X., & Xie, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500300200 · Cited by 123 · see citing works
Amieux, P. S., Howe, D. G., Knickerbocker, H., Lee, D. C., Su, T. T., Laszlo, G. S., Idzerda, R. L., & McKnight, G. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200302200 · Cited by 111 · see citing works
Shaikh, D., Zhou, Q., Chen, T., Ibe, J. C. F., Raj, J. U., & Zhou, G. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.08.007 · Cited by 92 · see citing works
MacPherson, M. R., Molina, P., Souchelnytskyi, S., Wernstedt, C., Martı́n-Pérez, J., Portillo, F., & Cano, A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-06-0504 · Cited by 74 · see citing works
Singh, R., Shankar, B. S., & Sainis, K. B. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.03.028 · Cited by 65 · see citing works
PROPPER, D. J., Saunders, M. P., Salisbury, A. J., Long, L., O'Byrne, K. J., Braybrooke, J. P., Dowsett, M., Taylor, M., Talbot, D. C., Ganesan, T. S., et al. (1999) · PubMed · Cited by 57 · see citing works
Cyclic Nucleotide‐Gated Channels: Molecular Mechanisms of Activation
Broillet, M.-C., & Firestein, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11352.x · Cited by 55 · see citing works
Growth properties and tumorigenesis of MCF-7 cells transfected with isogenic mutants of rasH.
Sommers, C. L., Papageorge, A. G., Wilding, G., & Gelmann, E. P. (1990) · PubMed · Cited by 50 · see citing works
Nadella, K. S., Jones, G. N., Trimboli, A. J., Stratakis, C. A., Leone, G. W., & Kirschner, L. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6002 · Cited by 37 · see citing works
Saunders, M. P., Salisbury, A. J., O'Byrne, K. J., Long, L., Whitehouse, R. M., Talbot, D. C., Mawer, E. B., & Harris, A. L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4410 · Cited by 26 · see citing works
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Sorted by citations
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492 · see citing works
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876 · see citing works
Self-citationEMT, CSCs, and drug resistance: the mechanistic link and clinical implications
Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539 · see citing works
Self-citationSingle-cell transcriptional diversity is a hallmark of developmental potential
Gulati, G. S., Sikandar, S. S., Wesche, D. J., Manjunath, A., Bharadwaj, A., Berger, M. J., Ilagan, F., Kuo, A. H., Hsieh, R. W., Cai, S., et al. (2020) · Science · doi:10.1126/science.aax0249 · Cited by 1,571 · see citing works
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Huang, Y., Hong, W., & Wei, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01347-8 · Cited by 1,065 · see citing works
Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis
Lu, W., & Kang, Y. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.010 · Cited by 1,022 · see citing works
EMT, cell plasticity and metastasis
Chaffer, C. L., Juan, B. P. S., Lim, E., & Weinberg, R. A. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9648-7 · Cited by 847 · see citing works
Self-citationThe great escape: tumour cell plasticity in resistance to targeted therapy
Boumahdi, S., & de Sauvage, F. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0044-1 · Cited by 759 · see citing works
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Zhang, Y., & Weinberg, R. A. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0656-6 · Cited by 660 · see citing works
Self-citationLineage plasticity in cancer: a shared pathway of therapeutic resistance
Quintanal-Villalonga, À., Chan, J. M., Yu, H. A., Pe’er, D., Sawyers, C. L., Sen, T., & Rudin, C. M. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0340-z · Cited by 573 · see citing works
Linking EMT programmes to normal and neoplastic epithelial stem cells
Lambert, A. W., & Weinberg, R. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00332-6 · Cited by 530 · see citing works
Self-citationAcquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
Kröger, C., Afeyan, A. B., Mraz, J., Eaton, E. N., Reinhardt, F., Khodor, Y. L., Thiru, P., Bierie, B., Ye, X., Burge, C. B., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812876116 · Cited by 493 · see citing works
Self-citationDifferentiation therapy revisited
de Thé, H. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2017.103 · Cited by 462 · see citing works
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression
Hu, Q., Ye, Y., Chan, L.-C., Li, Y., Liang, K., Lin, A., Egranov, S. D., Zhang, Y., Xia, W., Gong, J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0400-7 · Cited by 352 · see citing works
Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer
Zhang, N., Ng, A. S., Cai, S., Li, Q., Li, Y., & Kerr, D. J. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00343-0 · Cited by 354 · see citing works
Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity
Wainwright, E. N., & Scaffidi, P. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.04.004 · Cited by 293 · see citing works
Bierie, B., Pierce, S. E., Kröger, C., Stover, D. G., Pattabiraman, D. R., Thiru, P., Donaher, J. L., Reinhardt, F., Chaffer, C. L., Keckesova, Z., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618298114 · Cited by 330 · see citing works
Self-citationMetabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer
Sciacovelli, M., & Frezza, C. (2017) · FEBS Journal · doi:10.1111/febs.14090 · Cited by 324 · see citing works
Tumor cell plasticity in targeted therapy-induced resistance: Mechanisms and new strategies
Shi, Z.-D., Pang, K., Wu, Z.-X., Dong, Y., Hao, L., Qin, J.-X., Wang, W., Chen, Z.-S., & Han, C.-H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01383-x · Cited by 256 · see citing works
Tyagi, A., Sharma, S., Wu, K., Wu, S.-Y., Xing, F., Liu, Y., Zhao, D., Deshpande, R. P., D’Agostino, R. B., & Watabe, K. (2021) · Nature Communications · doi:10.1038/s41467-020-20733-9 · Cited by 246 · see citing works
RetractedImproved reconstruction of single-cell developmental potential with CytoTRACE 2
Kang, M., Armenteros, J. J. A., Gulati, G. S., Gleyzer, R., Avagyan, S., Brown, E. L., Zhang, W., Usmani, A., Earland, N. J., Wu, Z., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02857-2 · Cited by 260 · see citing works
Seo, N., Shirakura, Y., Tahara, Y., Momose, F., Harada, N., Ikeda, H., Akiyoshi, K., & Shiku, H. (2018) · Nature Communications · doi:10.1038/s41467-018-02865-1 · Cited by 239 · see citing works
Huang, H., Wang, Y., Kandpal, M., Zhao, G., Cárdenas, H., Ji, Y., Chaparala, A., Tanner, E. J., Chen, J., Davuluri, R. V., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-4044 · Cited by 221 · see citing works
Cancer metabolism in space and time: Beyond the Warburg effect
Danhier, P., Bański, P., Payen, V. L., Grasso, D., Ippolito, L., Sonveaux, P., & Porporato, P. E. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.02.001 · Cited by 214 · see citing works
Cancer cell plasticity: Impact on tumor progression and therapy response
da Silva-Diz, V., Lorenzo-Sanz, L., Bernat‐Peguera, A., Lopez-Cerda, M., & Muñoz, P. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.08.009 · Cited by 202 · see citing works
Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0122-3 · Cited by 192 · see citing works
Therapeutic implications of cancer epithelial-mesenchymal transition (EMT)
Cho, E. S., Kang, H. E., Kim, N. H., & Yook, J. I. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-018-01108-7 · Cited by 179 · see citing works
Basu, S., Cheriyamundath, S., & Ben‐Ze'ev, A. (2018) · F1000Research · doi:10.12688/f1000research.15782.1 · Cited by 175 · see citing works
Collective migration and cell jamming in asthma, cancer and development
Park, J., Atia, L., Mitchel, J. A., Fredberg, J. J., & Butler, J. P. (2016) · Journal of Cell Science · doi:10.1242/jcs.187922 · Cited by 173 · see citing works
Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target
Jonckheere, S., Adams, J., Groote, D. D., Campbell, K., Berx, G., & Goossens, S. (2021) · Cells Tissues Organs · doi:10.1159/000512218 · Cited by 173 · see citing works
Huang, Z., Zhang, Z., Zhou, C., Liu, L., & Huang, C. (2022) · MedComm · doi:10.1002/mco2.144 · Cited by 170 · see citing works
Castaño, Z., Juan, B. P. S., Spiegel, A., Pant, A., DeCristo, M. J., Laszewski, T., Ubellacker, J. M., Janssen, S. R., Dongre, A., Reinhardt, F., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0173-5 · Cited by 166 · see citing works
Self-citationInterplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies
Tanabe, S., Quader, S., Cabral, H., & Ono, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00904 · Cited by 161 · see citing works
Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death
Sun, Q., Zhou, H., & Mao, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2749173 · Cited by 157 · see citing works
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation
Jones, R. A., Robinson, T., Liu, J. C., Shrestha, M., Voisin, V., Ju, Y., Chung, P. E. D., Pellecchia, G., Fell, V. L., Bae, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81568 · Cited by 145 · see citing works
The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas
Fedele, M., Cerchia, L., & Chiappetta, G. (2017) · Cancers · doi:10.3390/cancers9100134 · Cited by 141 · see citing works
The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?
Sapio, L., Gallo, M., Illiano, M., Chiosi, E., Naviglio, D., Spina, A., & Naviglio, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25650 · Cited by 138 · see citing works
Epithelial-to-mesenchymal transition in tumor progression
Prieto‐García, E., Díaz-García, C. V., García‐Ruíz, I., & Agulló-Ortuño, M. T. (2017) · Medical Oncology · doi:10.1007/s12032-017-0980-8 · Cited by 135 · see citing works
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
Sun, Z., Jiang, Q., Li, J., & Guo, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00265-w · Cited by 130 · see citing works
Gooding, A. J., & Schiemann, W. P. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0067 · Cited by 136 · see citing works
Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
Wu, Y., Wang, Y., Lin, Y., Liu, Y., Wang, Y., Jia, J., Singh, P., Chi, Y., Wang, C., Dong, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14228 · Cited by 133 · see citing works
Wu, W., Chen, F., Cui, X., Yang, L., Chen, J., Zhao, J., Huang, D., Liu, J., Yang, L., Zeng, J., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31605 · Cited by 126 · see citing works
Liu, Q., Hodge, J., Wang, J., Wang, Y., Wang, L., Singh, U. P., Li, Y., Yao, Y., Wang, D., Ai, W., et al. (2020) · Theranostics · doi:10.7150/thno.45395 · Cited by 128 · see citing works
MiRNA-mediated EMT and CSCs in cancer chemoresistance
Dong, B., Li, S., Zhu, S., Yi, M., Luo, S., & Wu, K. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00206-5 · Cited by 127 · see citing works
Čoma, M., Fröhlichová, L., Urban, L., Zajíček, R., Urban, T., Szabó, P., Novak, S., Fetissov, V., Dvořánková, B., Smetana, K., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020897 · Cited by 121 · see citing works
Hu, X., Harvey, S. E., Zheng, R., Lyu, J., Grzeskowiak, C. L., Powell, E., Piwnica-Worms, H. M., Scott, K. L., & Cheng, C. (2020) · Nature Communications · doi:10.1038/s41467-020-14304-1 · Cited by 109 · see citing works
Cohen, J. N., Joseph, N. M., North, J. P., Onodera, C. S., Zembowicz, A., & LeBoit, P. E. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000902 · Cited by 108 · see citing works
Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer
Ashrafizadeh, M., Hushmandi, K., Hashemi, M., Akbari, M. E., Kubatka, P., Raei, M., Koklesová, L., Shahinozzaman, M., Mohammadinejad, R., Najafi, M., et al. (2020) · Biomolecules · doi:10.3390/biom10081159 · Cited by 107 · see citing works
Paul, M. R., Pan, T.-C., Pant, D. K., Shih, N. N. C., Chen, Y., Harvey, K. L., Solomon, A. C., Lieberman, D. B., Morrissette, J. J. D., Soucier-Ernst, D., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129941 · Cited by 105 · see citing works
Circulating Tumor Cells: Fluid Surrogates of Solid Tumors
Thiele, J.-A., Bethel, K., Králíčková, M., & Kuhn, P. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100256 · Cited by 107 · see citing works
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
Song, A., Zhang, Y., Han, L., Yegutkin, G. G., Liu, H., Sun, K., D’Alessandro, A., Li, J., Karmouty‐Quintana, H., Iriyama, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14108 · Cited by 98 · see citing works
The EMT spectrum and therapeutic opportunities
Voon, D. C., Huang, R. Y., Jackson, R. A., & Thiery, J. P. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12082 · Cited by 99 · see citing works
Loo, S. Y., Toh, L. P., Xie, W. H., Pathak, E., Tan, W. W. S., Ma, S., Lee, M. Y., Shatishwaran, S., Yeo, J. Z. Z., Yuan, J. X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh2443 · Cited by 94 · see citing works
Self-citationLessons Learned from Two Decades of Anticancer Drugs
Liu, Z., Delavan, B., Roberts, R. A., & Tong, W. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.06.005 · Cited by 95 · see citing works
New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
Bhatia, S., Wang, P., Toh, A. K. L., & Thompson, E. W. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00071 · Cited by 94 · see citing works
Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis
Dong, Y., Hu, H., Zhang, X., Zhang, Y., Sun, X., Wang, H., Kan, W., Tan, M., Shi, H., Zang, Y., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01302-6 · Cited by 95 · see citing works
The Role of lncRNAs in the Distant Metastasis of Breast Cancer
Wu, Y., Shao, A., Wang, L., Hu, K., Yu, C., Pan, C., & Zhang, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00407 · Cited by 89 · see citing works
Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution
Shlyakhtina, Y., Moran, K. L., & Portal, M. M. (2021) · Cancers · doi:10.3390/cancers13061380 · Cited by 91 · see citing works
The Cellular Origin and Evolution of Breast CancerPreprint
Zhang, M., Lee, A. V., & Rosen, J. M. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a027128 · Cited by 89 · see citing works
Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
Tian, W., Liu, Y., Cao, C., Zeng, Y., Pan, Y., Liu, X., Peng, Y., & Wu, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.777018 · Cited by 89 · see citing works
Cell plasticity in cancer cell populations
Shen, S., & Clairambault, J. (2020) · F1000Research · doi:10.12688/f1000research.24803.1 · Cited by 86 · see citing works
Shi, L., Wu, Z., Miao, J., Du, S., Ai, S., Xu, E., Feng, M., Song, J., & Guan, W. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-03-0136 · Cited by 79 · see citing works
Coles, G. L., Cristea, S., Webber, J. T., Levin, R. S., Moss, S. M., He, A., Sangodkar, J., Hwang, Y. C., Arand, J., Drainas, A. P., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.003 · Cited by 81 · see citing works
Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling
Fröse, J., Chen, M. B., Hebron, K. E., Reinhardt, F., Hajal, C., Zijlstra, A., Kamm, R. D., & Weinberg, R. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.092 · Cited by 79 · see citing works
Self-citationKhatib, A., Solaimuthu, B., Yosef, M. B., Rmaileh, A. A., Tanna, M., Oren, G., Frisch, M. S., Axelrod, J. H., Lichtenstein, M., & Shaul, Y. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010275117 · Cited by 77 · see citing works
Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning
Burkhardt, D. B., Juan, B. P. S., Lock, J. G., Krishnaswamy, S., & Chaffer, C. L. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0282 · Cited by 70 · see citing works
MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state
Cui, J., Zhang, C., Lee, J., Bartholdy, B., Yang, D., Liu, Y., Erler, P., Galbo, P. M., Hodge, D. Q., Huangfu, D., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-022-01045-0 · Cited by 74 · see citing works
Ramms, D. J., Raimondi, F., Arang, N., Herberg, F. W., Taylor, S. S., & Gutkind, J. S. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000269 · Cited by 71 · see citing works
Giacomelli, C., Daniele, S., Romei, C., Tavanti, L. M., Neri, T., Piano, I., Celi, A., Martini, C., & Trincavelli, M. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00054 · Cited by 73 · see citing works
Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance
Xu, Z., Zhang, Y., Dai, H., & Han, B. (2022) · Molecules · doi:10.3390/molecules27154750 · Cited by 72 · see citing works
Hao, C., Gély-Pernot, A., Kervarrec, C., Boudjema, M., Becker, E., Khil, P. P., Tevosian, S. G., Jégou, B., & Smagulova, F. O. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw840 · Cited by 71 · see citing works
Ghahhari, N. M., Sznurkowska, M. K., Hulo, N., Bernasconi, L., Aceto, N., & Picard, D. (2022) · Nature Communications · doi:10.1038/s41467-022-29723-5 · Cited by 70 · see citing works
Tan, X., Banerjee, P., Liu, X., Yu, J., Gibbons, D. L., Wu, P., Scott, K. L., Diao, L., Zheng, X., Wang, J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97225 · Cited by 68 · see citing works
Zhao, X., Deng, P., Iglesias‐Bartolomé, R., Amornphimoltham, P., Steffen, D. J., Jin, Y., Molinolo, A., de Castro, L. F., Ovejero, D., Yuan, Q., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713710115 · Cited by 68 · see citing works
Oberstein, A., & Shenk, T. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710799114 · Cited by 66 · see citing works
Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based TherapyPreprint
Pattabiraman, D. R., & Weinberg, R. A. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030957 · Cited by 64 · see citing works
Self-citationContribution of Epithelial Plasticity to Therapy Resistance
Santamarı́a, P. G., Moreno‐Bueno, G., & Cano, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050676 · Cited by 62 · see citing works
PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer
Xia, L., Sun, J., Xie, S., Chi, C., Zhu, Y., Pan, J., Dong, B., Huang, Y., Xia, W., Sha, J., et al. (2020) · Cell Proliferation · doi:10.1111/cpr.12918 · Cited by 62 · see citing works
Sun, J., Li, Q., Lian, X., Zhu, Z., Chen, X., Pei, W., Li, S., Abbas, A., Wang, Y., & Tian, L. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.10.017 · Cited by 62 · see citing works
Zhao, N., Powell, R. T., Yuan, X., Bae, G., Roarty, K. P., Stossi, F., Strempfl, M., Toneff, M. J., Johnson, H. L., Mani, S. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24545-3 · Cited by 61 · see citing works
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
Cumin, C., Huang, Y., Rossdam, C., Ruoff, F., Posada-Céspedes, S., Liang, C.-Y., Lombardo, F. C., Coelho, R., Rimmer, N., Konantz, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111181 · Cited by 57 · see citing works
Sheikh, A., Tumala, B., Vickers, T. J., Martin, J. C., Rosa, B. A., Sabui, S., Basu, S., Simões, R. D., Mitreva, M., Storer, C. E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34687-7 · Cited by 59 · see citing works
Pappa, S., Padilla, N., Iacobucci, S., Vicioso‐Mantis, M., de la Campa, E. Á., Navarro, C., Marcos-Grañeda, E., de la Cruz, X., & Martínez‐Balbás, M. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903188116 · Cited by 59 · see citing works
Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option
Bucko, P. J., & Scott, J. D. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-022420-112134 · Cited by 57 · see citing works
Mechanism of cancer stemness maintenance in human liver cancer
Liang, N. N., Yang, T., Huang, Q., Yu, P., Liu, C., Chen, L., Wang, Q., Wang, G., & He, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04848-z · Cited by 58 · see citing works
Turnham, R. E., Smith, F. D., Kenerson, H. L., Omar, M. H., Golkowski, M. G., Garcia, I., Bauer, R. L., Lau, H.-T., Sullivan, K. M., Langeberg, L. K., et al. (2019) · eLife · doi:10.7554/elife.44187 · Cited by 55 · see citing works
Kvokačková, B., Remšík, J., Jolly, M. K., & Souček, K. (2021) · Cancers · doi:10.3390/cancers13092188 · Cited by 57 · see citing works
Ioris, R. M., Galiè, M., Ramadori, G., Anderson, J. G., Charollais, A., Konstantinidou, G., Brénachot, X., Aras, E., Goga, A., Ceglia, N., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.065 · Cited by 57 · see citing works
Epigenetic determinants of metastasis
Patel, S. A., & Vanharanta, S. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.09.008 · Cited by 56 · see citing works
OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor
Fan, C., Wang, Q., van der Zon, G., Ren, J., Agaser, C., Slieker, R. C., Iyengar, P. V., Mei, H., & ten Dijke, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00944-w · Cited by 55 · see citing works
Cancer stem cells and tumor heterogeneity: Deciphering the role in tumor progression and metastasis
Kapoor-Narula, U., & Lenka, N. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155968 · Cited by 58 · see citing works
Walia, M., Ho, P. M., Taylor, S., Ng, A. J., Gupte, A., Chalk, A. M., Zannettino, A. C. W., Martin, T. J., & Walkley, C. R. (2016) · eLife · doi:10.7554/elife.13446 · Cited by 55 · see citing works
Li, H., Bi, Y.-R., Yang, L., Fu, R., Lv, W.-C., Jiang, N., Xu, Y., Ren, B., Chen, Y., Xie, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaw8500 · Cited by 53 · see citing works
Khan, A. Q., Hasan, A., Mir, S. S., Rashid, K., Shahab Uddin, M. S., & Steinhoff, M. S. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.03.002 · Cited by 57 · see citing works
Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites
Melzer, C., von der Ohe, J., & Hass, R. (2017) · BioMed Research International · doi:10.1155/2017/8534371 · Cited by 53 · see citing works
Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy
Chen, F., Chen, L., Qin, Q., & Sun, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00018 · Cited by 53 · see citing works
Lee, Y., Kim, J., Lee, J. Y., Lee, J. H. J., Sahu, S., Kwon, H., Park, S. J., Jang, S., Lee, J., Wang, Z., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712920 · Cited by 52 · see citing works
Self-citationBaj, J., Brzozowska, K., Forma, A., Maani, A., Sitarz, E., & Portincasa, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072544 · Cited by 50 · see citing works
Cumin, C., Huang, Y., Everest‐Dass, A., & Jacob, F. (2021) · Biomolecules · doi:10.3390/biom11010062 · Cited by 49 · see citing works
Mechanisms of colorectal liver metastasis development
Shasha, T., Gruijs, M., & van Egmond, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04630-6 · Cited by 49 · see citing works
- Authors
- Pattabiraman, D. R., Bierie, B., Kober, K. I., Thiru, P., Krall, J. A., Zill, C., Reinhardt, F., Tam, W. L., & Weinberg, R. A.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Weinberg, Robert A.
- ORCID
- Venue
- Science
- Published
- 2016-03-04
- Volume
- 351
- Issue
- 6277
- Pages
- aad3680-aad3680
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5131720
- OpenAlex
- W2289283229
- Cited by
- 332
- References
- 60
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 32 · 2023: 26 · 2022: 35 · 2021: 36 · 2020: 47 · 2019: 32 · 2018: 36 · 2017: 41 · 2016: 18
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- National Health and Medical Research Council of Australia (NHMRC APP1071853)
- National Research Foundation, Singapore (NRF-NRFF2015-04)
- National Medical Research Council, Singapore (NMRC/TCR/007-NCC/2013)
- Ludwig Center for Molecular Oncology at MIT
- Breast Cancer Research Foundation
- Samuel Waxman Cancer Research Foundation
- NIH (R01-CA078461)
- American Cancer Society
- D. K. Ludwig Foundation Cancer Research
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- protein kinase A, mesenchymal-epithelial transition, cancer stem cells, PHF2, histone demethylase, epigenetic reprogramming, cAMP signaling, mammary epithelial cells, differentiation therapy
- MeSH terms
- Adenosine Monophosphate, Animals, Breast Neoplasms, Cell Transformation, Neoplastic, Cholera Toxin, Enzyme Activation, Epithelial Cells, Female, Colforsin, Humans, Mesoderm, Neoplastic Stem Cells, Second Messenger Systems, Cyclic AMP-Dependent Protein Kinases, Homeodomain Proteins, Xenograft Model Antitumor Assays, Mammary Glands, Human, Epigenesis, Genetic, Cell Line, Tumor, Mice, Histone Demethylases, Epithelial-Mesenchymal Transition
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