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Cited by 179Neural dynamics and brain functionMemory and Neural MechanismsSleep and Wakefulness Research

Breathing coordinates cortico-hippocampal dynamics in mice during offline states

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Karalis, Nikolaos, Sirota, Anton·2022·Nature Communications
DOI 10.1038/s41467-022-28090-5PMC PMC8786964

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Abstract

Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits. However, little is known about the mechanisms that synchronize and coordinate these processes across widespread brain regions during offline states. Here we address the hypothesis that breathing acts as an oscillatory pacemaker, persistently coupling distributed brain circuit dynamics. Using large-scale recordings from a number of cortical and subcortical brain regions in behaving mice, we uncover the presence of an intracerebral respiratory corollary discharge, that modulates neural activity across these circuits. During offline states, the respiratory modulation underlies the coupling of hippocampal sharp-wave ripples and cortical DOWN/UP state transitions, which mediates systems memory consolidation. These results highlight breathing, a perennial brain rhythm, as an oscillatory scaffold for the functional coordination of the limbic circuit that supports the segregation and integration of information flow across neuronal networks during offline states.

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  • Respiration is also coupled to neural activity in the visual system and influences visual performance.

    “Third, respiration is also coupled to neural activity in the visual system 128,141,146 and influences visual performance 140,146,147 .”

    From Interoceptive rhythms in the brain (2023) · cites this paper as [128]

    The Results section, “Widespread respiratory modulation of limbic circuits during offline states” (page not specified), reports that visual-cortex activity in mice was coupled to breathing. The paper also describes breathing-phase modulation of visually evoked cortical responses, but the passages do not establish an effect on visual performance. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Experimentally, there are only few studies detailing whether different brain regions are coupled to a bodily rhythm with the same phase or different ones, and they are not congruent.

    “Experimentally, there are only few studies detailing whether different brain regions are coupled to a bodily rhythm with the same phase or different ones, and they are not congruent:”

    From Interoceptive rhythms in the brain (2023) · cites this paper as [128]

    The Results section (“Widespread respiratory modulation of limbic circuits during offline states”; page not available) examines how activity in multiple brain regions relates to breathing phase and reports that neurons in several regions fire at distinct phases. The paper does not establish that only a few studies have examined this question or that those studies’ findings are incongruent. (LLM, conf=0.80)

    Experimental — accuracy not yet measured

  • The phase alignment of respiratory-driven neural activity seems rather good.

    “the phase alignment of respiratory-driven neural activity seems rather good 128 ,”

    From Interoceptive rhythms in the brain (2023) · cites this paper as [128]

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Cited by

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Authors
Karalis, N., & Sirota, A.
Affiliations
Ludwig-Maximilians-Universität München (DE)
Corresponding author
  • Karalis, Nikolaos
  • Sirota, Anton
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2022-01-24
Volume
13
Issue
1
Pages
467-467
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-022-28090-5
PMC
PMC8786964
OpenAlex
W4207064626
Cited by
179
References
15
Citations by year
2026: 33 · 2025: 39 · 2024: 40 · 2023: 35 · 2022: 32
FWCI
18.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion, cc-by)
Funders
  • European Molecular Biology Organization (Long-term fellowship ALTF 914-2018)
  • EC | Horizon 2020 Framework Programme (Marie Skłodowska-Curie grant agreement No. 843236, FETPROACT 723032 (BrainCom))
  • Deutsche Forschungsgemeinschaft (Synergy, Exc1010, SPP 1665, RTG 2175)
  • Bundesministerium für Bildung und Forschung (BCCN Munich 01GQ0440)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
breathing, respiratory rhythm, sharp-wave ripples, memory consolidation, corollary discharge, limbic system, neural oscillations
MeSH terms
Memory Consolidation, Animals, Cerebral Cortex, Electrophysiology, Hippocampus, Mice, Inbred C57BL, Respiration, Sleep, Mice

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