Dynamics of the Hippocampal Ensemble Code for Space

Wilson, Matthew A.; McNaughton, Bruce L.

doi:10.1126/science.8351520

Cited by 2,350Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Dynamics of the Hippocampal Ensemble Code for Space

Wilson, Matthew A., McNaughton, Bruce L.·1993·Science

DOI 10.1126/science.8351520

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Abstract

Ensemble recordings of 73 to 148 rat hippocampal neurons were used to predict accurately the animals' movement through their environment, which confirms that the hippocampus transmits an ensemble code for location. In a novel space, the ensemble code was initially less robust but improved rapidly with exploration. During this period, the activity of many inhibitory cells was suppressed, which suggests that new spatial information creates conditions in the hippocampal circuitry that are conducive to the synaptic modification presumed to be involved in learning. Development of a new population code for a novel environment did not substantially alter the code for a familiar one, which suggests that the interference between the two spatial representations was very small. The parallel recording methods outlined here make possible the study of the dynamics of neuronal interactions during unique behavioral events.

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Authors: Wilson, M. A., & McNaughton, B. L.
Affiliations: University of Arizona (US)
ORCID: Wilson, Matthew A.
McNaughton, Bruce L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1993-08-20
Volume: 261
Issue: 5124
Pages: 1055-1058
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8351520
OpenAlex: W1969769253
Cited by: 2,350
References: 33
Citations by year: 2026: 38 · 2025: 74 · 2024: 84 · 2023: 87 · 2022: 68 · 2021: 59 · 2020: 71 · 2019: 86 · 2018: 82 · 2017: 86 · 2016: 65 · 2015: 62 · 2014: 98 · 2013: 87 · 2012: 72
FWCI: 39.09
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 46823)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampus, ensemble coding, spatial representation, place cells, rats, exploration, inhibitory interneurons, synaptic plasticity, learning, novel environment, parallel recording, neuronal interactions, location prediction
MeSH terms: Animals, Behavior, Animal, Exploratory Behavior, Hippocampus, Interneurons, Male, Memory, Neurons, Rats, Inbred F344, Space Perception, Rats

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Dynamics of the Hippocampal Ensemble Code for Space

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