The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
Open accessAbstract
Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables the discovery of potential therapeutic targets. Here, we profile 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidate the potential origin and regulation of tumor-enriched cell types in CRC. We demonstrate that the tumor-specific FAP+ fibroblasts and SPP1+ macrophages were positively correlated in 14 independent CRC cohorts containing 2550 samples and validate their close localization by immuno-fluorescent staining and spatial transcriptomics. This interaction might be regulated by chemerin, TGF-β, and interleukin-1, which would stimulate the formation of immune-excluded desmoplasic structure and limit the T cell infiltration. Furthermore, we find patients with high FAP or SPP1 expression achieved less therapeutic benefit from an anti-PD-L1 therapy cohort. Our results provide a potential therapeutic strategy by disrupting FAP+ fibroblasts and SPP1+ macrophages interaction to improve immunotherapy.
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Cites
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Cited by
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Metadata
- Authors
- Qi, J., Sun, H., Zhang, Y., Wang, Z., Xun, Z., Li, Z., Ding, X., Bao, R., Hong, L., Jia, W., Fang, F., Liu, H., Chen, L., Zhong, J., Zou, D., Liu, L., Han, L., Ginhoux, F., Liu, Y., Ye, Y., & Su, B.
- Venue
- Nature Communications
- Published
- 2022-04-01
- Volume
- 13
- Issue
- 1
- Pages
- 1742-1742
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4221123198
- Cited by
- 952
- References
- 91
- FWCI
- 58.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Qi, J., Sun, H., Zhang, Y., Wang, Z., Xun, Z., Li, Z., Ding, X., Bao, R., Hong, L., Jia, W., Fang, F., Liu, H., Chen, L., Zhong, J., Zou, D., Liu, L., Han, L., Ginhoux, F., Liu, Y., . . . Su, B. (2022). Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nature Communications. https://doi.org/10.1038/s41467-022-29366-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
