The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma
Open accessAbstract
Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of the multicellular ecosystem of HCC from four tissue sites. We show the enrichment of central memory T cells (T CM) in the early tertiary lymphoid structures (E-TLSs) in HCC and assess the relationships between chronic HBV/HCV infection and T cell infiltration and exhaustion. We find the MMP9+macrophages to be terminally differentiated tumor-associated macrophages (TAMs) and PPARγ to be the pivotal transcription factor driving their differentiation. We also characterize the heterogeneous subpopulations of malignant hepatocytes and their multifaceted functions in shaping the immune microenvironment of HCC. Finally, we identify seven microenvironment-based subtypes that can predict prognosis of HCC patients. Collectively, this large-scale atlas deepens our understanding of the HCC microenvironment, which might facilitate the development of new immune therapy strategies for this malignancy.
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Cited by
Ma, C., Yang, C., Peng, A., Sun, T., Ji, X., Mi, J., Wei, L., Shen, S., & Feng, Q. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01876-x · Cited by 284
Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma
Chan, Y.-T., Zhang, C., Wu, J., Lu, P., Xu, L., Yuan, H., Feng, Y., Chen, Z.-S., & Wang, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02101-z · Cited by 281
Kohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1129831 · Cited by 27
Zhang, S., Xu, H., Li, M., Yuan, G., Nie, J., Zhang, Q., Shi, J., Liu, D., Meng, H., Dong, W., et al. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2025.10.026 · Cited by 27
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Zhao, D., Huang, Z., Li, X., Wang, H., Hou, Q., Wang, Y., Yan, F., Yang, W., Liu, D., Yi, S., et al. (2024) · eLife · doi:10.7554/elife.95811 · Cited by 17
Metadata
- Authors
- Lu, Y., Yang, A., Quan, C., Pan, Y., Zhang, H., Li, Y., Gao, C., Lu, H., Wang, X., Cao, P., Chen, H., Lu, S., & Zhou, G.
- Venue
- Nature Communications
- Published
- 2022-08-06
- Volume
- 13
- Issue
- 1
- Pages
- 4594-4594
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4290072634
- Cited by
- 517
- References
- 57
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lu, Y., Yang, A., Quan, C., Pan, Y., Zhang, H., Li, Y., Gao, C., Lu, H., Wang, X., Cao, P., Chen, H., Lu, S., & Zhou, G. (2022). A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma. Nature Communications. https://doi.org/10.1038/s41467-022-32283-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
