The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In situ analysis of nanoparticle soft corona and dynamic evolution
Open accessAbstract
How soft corona, the protein corona’s outer layer, contributes to biological identity of nanomaterials is largely because capturing protein composition of the soft corona in situ remains challenging. We herein develop an in situ Fishing method that can monitor the dynamic formation of protein corona on ultra-small chiral Cu 2 S nanoparticles (NPs) allowing us to directly separate and identify the corona protein composition. Our method detects spatiotemporal processes in the evolution of hard and soft coronas on chiral NPs, revealing subtle differences in NP − protein interactions even within several minutes. This study highlights the importance of in situ and dynamic analysis of soft/hard corona, provides insights into the role of soft corona in mediating biological responses of NPs, and offers a universal strategy to characterize soft corona to guide the rational design of biomedical nanomaterials.
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Cites
Time Evolution of the Nanoparticle Protein Corona
Casals, E., Pfaller, T., Duschl, A., Oostingh, G. J., & Puntes, V. (2010) · ACS Nano · doi:10.1021/nn901372t · Cited by 1,211
Hou, K., Zhao, J., Wang, H., Li, B., Li, K., Shi, X., Wan, K., Ai, J., Lv, J., Wang, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18525-2 · Cited by 373
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Metadata
- Authors
- Baimanov, D., Wang, J., Zhang, J., Liu, K., Cong, Y., Shi, X., Zhang, X., Li, Y., Li, X., Qiao, R., Zhao, Y., Zhou, Y., Wang, L., & Chen, C.
- Venue
- Nature Communications
- Published
- 2022-09-14
- Volume
- 13
- Issue
- 1
- Pages
- 5389-5389
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4295678900
- Cited by
- 207
- References
- 2
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Baimanov, D., Wang, J., Zhang, J., Liu, K., Cong, Y., Shi, X., Zhang, X., Li, Y., Li, X., Qiao, R., Zhao, Y., Zhou, Y., Wang, L., & Chen, C. (2022). In situ analysis of nanoparticle soft corona and dynamic evolution. Nature Communications. https://doi.org/10.1038/s41467-022-33044-y
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