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Cited by 13Axon Guidance and Neuronal SignalingNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

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Subcellular second messenger networks drive distinct repellent-induced axon behaviors

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Baudet, Sarah, Zagar, Yvrick, Roche, Fiona, Gomez-Bravo, Claudia, Couvet, Sandrine, Bécret, Johann, Belle, Morgane, Vougny, Juliette, Uthayasuthan, Sinthuya, Ros, Oriol, Nicol, Xavier·2023·Nature Communications
DOI 10.1038/s41467-023-39516-zPMC PMC10300027

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Abstract

Second messengers, including cAMP, cGMP and Ca 2+ are often placed in an integrating position to combine the extracellular cues that orient growing axons in the developing brain. This view suggests that axon repellents share the same set of cellular messenger signals and that axon attractants evoke opposite cAMP, cGMP and Ca 2+ changes. Investigating the confinement of these second messengers in cellular nanodomains, we instead demonstrate that two repellent cues, ephrin-A5 and Slit1, induce spatially segregated signals. These guidance molecules activate subcellular-specific second messenger crosstalk, each signaling network controlling distinct axonal morphology changes in vitro and pathfinding decisions in vivo.

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Metadata

Authors
Baudet, S., Zagar, Y., Roche, F., Gomez-Bravo, C., Couvet, S., Bécret, J., Belle, M., Vougny, J., Uthayasuthan, S., Ros, O., & Nicol, X.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Nicol, Xavier
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2023-06-27
Volume
14
Issue
1
Pages
3809-3809
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-023-39516-z
PMC
PMC10300027
OpenAlex
W4382344515
Cited by
13
References
1
Citations by year
2026: 3 · 2025: 8 · 2023: 2
FWCI
1.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Agence Nationale de la Recherche (ANR-18-CE16-0017, ANR‐10‐LABX‐65, ANR18, 10-LABX-65, ANR-18-IAHU-0001, ANR-10)
  • Fondation pour la Recherche Médicale (ANR-10-LABX-65, FDT202204014862)
  • Fondation de France (00099274)
  • Fondation Voir et Entendre (ANR-10-LABX-65)
  • Sorbonne Université
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
axon guidance, second messengers, cyclic AMP, cyclic GMP, calcium signaling, ephrin-A5, Slit1, axon morphology, nanodomains
MeSH terms
Axons, Cyclic GMP, Second Messenger Systems, Signal Transduction

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