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Cited by 202Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsWound Healing and Treatments

A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer

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Cui, Chunyan, Mei, Li, Wang, Danyang, Jia, Pengfei, Zhou, Qihui, Liu, Wenguang·2023·Nature Communications
DOI 10.1038/s41467-023-43571-xPMC PMC10673908
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Abstract

Oral ulcer can be treated with diverse biomaterials loading drugs or cytokines. However, most patients do not benefit from these materials because of poor adhesion, short-time retention in oral cavity and low drug therapeutic efficacy. Here we report a self-stabilized and water-responsive deliverable coenzyme salt polymer poly(sodium α-lipoate) (PolyLA-Na)/coenzyme polymer poly(α-lipoic acid) (PolyLA) binary synergistic elastomer adhesive patch, where hydrogen bonding cross-links between PolyLA and PolyLA-Na prevents PolyLA depolymerization and slow down the dissociation of PolyLA-Na, thus allowing water-responsive sustainable delivery of bioactive LA-based small molecules and durable adhesion to oral mucosal wound due to the adhesive action of PolyLA. In the model of mice and mini-pig oral ulcer, the adhesive patch accelerates the healing of the ulcer by regulating the damaged tissue inflammatory environment, maintaining the stability of oral microbiota, and promoting faster re-epithelialization and angiogenesis. This binary synergistic patch provided a therapeutic strategy to treat oral ulcer.

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  • The oral mucosa is a mechanically and biologically dynamic interface exposed to saliva, friction, food stimulation, microbial colonization, and repeated wound contamination.

    “The oral mucosa is a mechanically and biologically dynamic interface exposed to saliva, friction, food stimulation, microbial colonization, and repeated wound contamination.60”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [60]

    The Introduction (page unavailable) describes the oral cavity as highly humid and dynamic, identifies saliva as a challenge for protecting injured mucosa, and says oral wounds are susceptible to bacterial infection. The Results (page unavailable) also describe the oral microbiota. The paper does not substantiate the more specific claims of exposure to friction, food stimulation, or repeated wound contamination. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Cell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.

    “Cell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [60]

    The Discussion (page not provided) reports improved wet adhesion, antioxidant and anti-inflammatory activity, and oral-mucosal healing. But the material studied is a PolyLA-Na/PolyLA adhesive patch, not a PDA-based coating or hydrogel; it releases its own bioactive molecules rather than delivering a loaded drug. (LLM, conf=0.88)

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References 67 · Cited by 202

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Authors
Cui, C., Mei, L., Wang, D., Jia, P., Zhou, Q., & Liu, W.
Affiliations
  • Tianjin University (CN)
  • Qingdao University (CN)
  • University of Health and Rehabilitation Sciences (CN)
Corresponding author
  • Zhou, Qihui
  • Liu, Wenguang
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2023-11-24
Volume
14
Issue
1
Pages
7707-7707
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-023-43571-x
PMC
PMC10673908
OpenAlex
W4388969693
Cited by
202
References
67
Citations by year
2026: 80 · 2025: 80 · 2024: 42
FWCI
22.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (52233008, 51733006, 52303201)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
oral ulcers, adhesive patch, sustained drug release, oral mucosal healing, re-epithelialization, angiogenesis, oral microbiota, inflammation regulation
MeSH terms
Adhesives, Animals, Humans, Polymers, Swine, Swine, Miniature, Oral Ulcer, Elastomers

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