Fusobacterium nucleatum — symbiont, opportunist and oncobacterium

Brennan, Caitlin A.; Garrett, Wendy S.

doi:10.1038/s41579-018-0129-6

Cited by 1,205Oral microbiology and periodontitis researchGut microbiota and healthMicrobial infections and disease research

Fusobacterium nucleatum — symbiont, opportunist and oncobacterium

Open access

Brennan, Caitlin A., Garrett, Wendy S.·2019·Nature Reviews Microbiology

DOI 10.1038/s41579-018-0129-6PMC PMC6589823

Open this paper in CoChat — free account

Abstract

Fusobacterium nucleatum has long been found to cause opportunistic infections and has recently been implicated in colorectal cancer; however, it is a common member of the oral microbiota and can have a symbiotic relationship with its hosts. To address this dissonance, we explore the diversity and niches of fusobacteria and reconsider historic fusobacterial taxonomy in the context of current technology. We also undertake a critical reappraisal of fusobacteria with a focus on F. nucleatum as a mutualist, infectious agent and oncogenic microorganism. In this Review, we delve into recent insights and future directions for fusobacterial research, including the current genetic toolkit, our evolving understanding of its mechanistic role in promoting colorectal cancer and the challenges of developing diagnostics and therapeutics for F. nucleatum.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41579-018-0129-6

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fusobacterium nucleatum usually resides in the middle of dental biofilms where it bridges early and late colonizers.
“Fusobacterium nucleatum, a spindle-shaped bacterium with multi-species coaggregation interactions [20,21] that usually resides in the middle of dental biofilms where it bridges early and late colonizers [22]”
From Coaggregation of oral pathogens by postbiotic lactobacilli (2025) · cites this paper as [22]
The “F. nucleatum as a mutualist” section says that F. nucleatum bridges primary and secondary colonizers in dental plaque biofilms. It does not establish that the bacterium usually resides in the physical middle of those biofilms; the section instead notes that plaque biogeography may be more complex than previously thought. Page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Various disease states are associated with the oral microbiome, including caries, periodontal disease, oral, esophageal, pancreatic, and colorectal cancers, cardiovascular disease, and inflammatory bowel disease.
“This is demonstrated by the association of various disease states with the oral microbiome, including not only caries and periodontal disease but also oral, esophageal, pancreatic, and colorectal cancers, cardiovascular disease, and inflammatory bowel disease.147, 148, 149, 150, 151, 152, 153”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [152]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Self-citation
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.008 · Cited by 2,198 · see citing works
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works
A new view of the tree of life
Hug, L. A., Baker, B. J., Anantharaman, K., Brown, C. T., Probst, A. J., Castelle, C. J., Butterfield, C. N., Hernsdorf, A. W., Amano, Y., Ise, K., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.48 · Cited by 2,039 · see citing works
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · see citing works
Self-citation
Multitarget Stool DNA Testing for Colorectal-Cancer Screening
Imperiale, T. F., Ransohoff, D. F., Itzkowitz, S. H., Levin, T. R., Lavin, P., Lidgard, G. P., Ahlquist, D. A., & Berger, B. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311194 · Cited by 1,900 · see citing works
Recovery of nearly 8,000 metagenome-assembled genomes substantially expands the tree of life
Parks, D. H., Rinke, C., Chuvochina, M., Chaumeil, P.-A., Woodcroft, B. J., Evans, P. N., Hugenholtz, P., & Tyson, G. W. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0012-7 · Cited by 1,882 · see citing works
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works
A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591 · see citing works
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574 · see citing works
Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., & Dove, W. F. (1992) · Science · doi:10.1126/science.1350108 · Cited by 1,537 · see citing works
Gut microbiome development along the colorectal adenoma-carcinoma sequence
Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506 · see citing works
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490 · see citing works
Self-citation
Oral multispecies biofilm development and the key role of cell–cell distance
Kolenbrander, P. E., Palmer, R. J., Periasamy, S., & Jakubovics, N. S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2381 · Cited by 1,309 · see citing works
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188 · see citing works
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., et al. (2018) · Science · doi:10.1126/science.aah3648 · Cited by 1,105 · see citing works
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310101 · Cited by 1,080 · see citing works
Self-citation
Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor−κB, and Up-regulating Expression of MicroRNA-21
Yang, Y. P., Weng, W., Peng, J., Hong, L., Yang, L., Toiyama, Y., Gao, R., Liu, M., Yin, M., Pan, C., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.018 · Cited by 1,015 · see citing works
Fat, fibre and cancer risk in African Americans and rural Africans
O’Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7342 · Cited by 982 · see citing works
Biogeography of a human oral microbiome at the micron scale
Mark Welch, J. L., Rossetti, B. J., Rieken, C. W., Dewhirst, F. E., & Borisy, G. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522149113 · Cited by 968 · see citing works
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · see citing works
Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc
Abed, J., Emgård, J. E. M., Zamir, G., Faroja, M., Almogy, G., Grenov, A., Sol, A., Naor, R., Pikarsky, E., Atlan, K. A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.006 · Cited by 888 · see citing works
Self-citation
Bacteremia Associated With Toothbrushing and Dental Extraction
Lockhart, P. B., Brennan, M. T., Sasser, H. C., Fox, P. C., Paster, B. J., & Bahrani‐Mougeot, F. K. (2008) · Circulation · doi:10.1161/circulationaha.107.758524 · Cited by 847 · see citing works
A microbial signature for Crohn's disease
Pascal, V., Pozuelo, M., Borruel, N., Casellas, F., Campos, D., Santiago, A., Martínez, X., Varela, E., Sarrabayrouse, G., Machiels, K., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313235 · Cited by 842 · see citing works
Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov
Duncan, S. H., Hold, G. L., Harmsen, H. J. M., Stewart, C. S., & Flint, H. J. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-6-2141 · Cited by 735 · see citing works
Gut mucosal microbiome across stages of colorectal carcinogenesis
Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., et al. (2015) · Nature Communications · doi:10.1038/ncomms9727 · Cited by 701 · see citing works
Microbiota organization is a distinct feature of proximal colorectal cancers
Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700 · see citing works
Fusobacterium nucleatum and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works
Self-citation
The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients
Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu787 · Cited by 625 · see citing works
Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host
Strauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 574 · see citing works
Human Infection with Fusobacterium necrophorum (Necrobacillosis), with a Focus on Lemierre's Syndrome
Riordan, T. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-07 · Cited by 563 · see citing works
Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis
Hatakeyama, M. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.008 · Cited by 557 · see citing works
The gut microbiota influences anticancer immunosurveillance and general health
Routy, B., Gopalakrishnan, V., Daillère, R., Zitvogel, L., Wargo, J. A., & Kroemer, G. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0006-2 · Cited by 523 · see citing works
Fusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 516 · see citing works
Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers
White, B. D., Chien, A. J., & Dawson, D. W. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.12.001 · Cited by 471 · see citing works
Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H.-O., Sugai, T., An, B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1865 · Cited by 465 · see citing works
Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis
Yamamura, K., Baba, Y., Nakagawa, S., Mima, K., Miyake, K., Nakamura, K., Sawayama, H., Kinoshita, K., Ishimoto, T., Iwatsuki, M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1786 · Cited by 457 · see citing works
Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth
Han, Y. W., Redline, R. W., Mei, L., Yin, L., Hill, G. B., & McCormick, T. S. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2272-2279.2004 · Cited by 454 · see citing works
Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum / necrophorum
Swidsinski, A. V., Dörffel, Y., Loening-Baucke, V. A., Theissig, F., Rueckert, J.-C., Ismail, M., Rau, W. A., Gaschler, D., Weizenegger, M., Kühn, S., et al. (2009) · Gut · doi:10.1136/gut.2009.191320 · Cited by 441 · see citing works
Variations in oral microbiota associated with oral cancer
Zhao, H., Chu, M., Huang, Z., Yang, X., Ran, S., Hu, B., Zhang, C., & Liang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-11779-9 · Cited by 438 · see citing works
Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells
Han, Y. W., Shi, W., Huang, G. T.-J., Kinder Haake, S., Park, N.-H., Kuramitsu, H., & Genco, R. J. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3140-3146.2000 · Cited by 435 · see citing works
TIGIT and CD 96: new checkpoint receptor targets for cancer immunotherapy
Dougall, W. C., Kurtuluş, S., Smyth, M. J., & Anderson, A. C. (2017) · Immunological Reviews · doi:10.1111/imr.12518 · Cited by 432 · see citing works
Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum
Bolstad, A. I., Jensen, H. B., & Bakken, V. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.1.55 · Cited by 426 · see citing works
Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model
Gallimidi, A. B., Fischman, S. L., Revach, B., Bulvik, R., Maliutina, A., Rubinstein, A. M., Nussbaum, G., & Elkin, M. (2015) · Oncotarget · doi:10.18632/oncotarget.4209 · Cited by 426 · see citing works
Inducible Expression of Human β-Defensin 2 byFusobacterium nucleatumin Oral Epithelial Cells: Multiple Signaling Pathways and Role of Commensal Bacteria in Innate Immunity and the Epithelial Barrier
Krisanaprakornkit, S., Kimball, J. R., Weinberg, A., Darveau, R. P., Bainbridge, B. W., & Dale, B. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2907-2915.2000 · Cited by 419 · see citing works
Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study
Audirac-Chalifour, A., Torres-Poveda, K., Bahena-Román, M., Téllez‐Sosa, J., Martínez-Barnetche, J., Cortina-Ceballos, B., López-Estrada, G., Delgado-Romero, K., Burguete-García, A. I., de León, D. F. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153274 · Cited by 404 · see citing works
Co-occurrence of anaerobic bacteria in colorectal carcinomas
Warren, R. L., Freeman, D. J., Pleasance, S., Watson, P., Moore, R. A., Cochrane, K., Allen-Vercoe, E., & Holt, R. A. (2013) · Microbiome · doi:10.1186/2049-2618-1-16 · Cited by 348 · see citing works
Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue
Mehta, R. S., Nishihara, R., Cao, Y., Song, M., Mima, K., Qian, Z. R., Nowak, J. A., Kosumi, K., Hamada, T., Masugi, Y., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.6374 · Cited by 325 · see citing works
Self-citation
Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity
Komiya, Y., Shimomura, Y., Higurashi, T., Sugi, Y., Arimoto, J., Umezawa, S., Uchiyama, S., Matsumoto, M., & Nakajima, A. (2018) · Gut · doi:10.1136/gutjnl-2018-316661 · Cited by 317 · see citing works
Inflammatory bacteriome featuring Fusobacterium nucleatum and Pseudomonas aeruginosa identified in association with oral squamous cell carcinoma
Al-Hebshi, N. N., Nasher, A. T., Maryoud, M. Y., Homeida, H. E., Chen, T., Idris, A. M., & Johnson, N. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-02079-3 · Cited by 314 · see citing works
An open investigation of the reproducibility of cancer biology research
Errington, T. M., Iorns, E., Gunn, W., Tan, F. E., Lomax, J., & Nosek, B. A. (2014) · eLife · doi:10.7554/elife.04333 · Cited by 312 · see citing works
Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomonas sputigena with strains from 11 genera of oral bacteria
Kolenbrander, P. E., Andersen, R. N., & Moore, L. V. (1989) · Infection and Immunity · doi:10.1128/iai.57.10.3194-3203.1989 · Cited by 298 · see citing works
Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity
Fardini, Y., Wang, X., Témoin, S., Nithianantham, S., Lee, D. M., Shoham, M., & Han, Y. W. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07905.x · Cited by 292 · see citing works
Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway: F. Nucleatum and molecular features of serrated lesions
Ito, M., Kanno, S., Nosho, K., Sukawa, Y., Mitsuhashi, K., Kurihara, H., Igarashi, H., Takahashi, T., Tachibana, M., Takahashi, H., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29488 · Cited by 288 · see citing works
Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location
Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.53 · Cited by 284 · see citing works
Self-citation
Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan
Hsieh, Y.-Y., Tung, S.-Y., Pan, H.-Y., Yen, C.-W., Xu, H.-W., Lin, Y.-J., Deng, Y.-F., Hsu, W.-T., Wu, C.-S., & Li, C. (2018) · Scientific Reports · doi:10.1038/s41598-017-18596-0 · Cited by 269 · see citing works
Identification and Characterization of a Novel Adhesin Unique to Oral Fusobacteria
Han, Y. W., Ikegami, A., Rajanna, C., Kawsar, H. I., Zhou, Y., Li, M., Sojar, H. T., Genco, R. J., Kuramitsu, H. K., & Deng, C. X. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.15.5330-5340.2005 · Cited by 260 · see citing works
The Fusobacterium nucleatum outer membrane protein RadD is an arginine‐inhibitable adhesin required for inter‐species adherence and the structured architecture of multispecies biofilm
Kaplan, C. W., Lux, R., Haake, S. K., & Shi, W. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06503.x · Cited by 252 · see citing works
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis
Tomkovich, S., Yang, Y., Winglee, K., Gauthier, J., Mühlbauer, M., Sun, X., Mohamadzadeh, M., Liu, X., Martin, P., Wang, G. P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3472 · Cited by 252 · see citing works
Fap2 of Fusobacterium nucleatum Is a Galactose-Inhibitable Adhesin Involved in Coaggregation, Cell Adhesion, and Preterm Birth
Coppenhagen‐Glazer, S., Sol, A., Abed, J., Naor, R., Zhang, X., Han, Y. W., & Bachrach, G. (2015) · Infection and Immunity · doi:10.1128/iai.02838-14 · Cited by 243 · see citing works
FadA from Fusobacterium nucleatum Utilizes both Secreted and Nonsecreted Forms for Functional Oligomerization for Attachment and Invasion of Host Cells
Xu, M., Yamada, M., Mei, L., Liu, H., Chen, S. G., & Han, Y. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611567200 · Cited by 199 · see citing works
Invasive Fusobacterium nucleatum may play a role in the carcinogenesis of proximal colon cancer through the serrated neoplasia pathway
Yu, J., Chen, Y., Fu, X., Zhou, X., Peng, Y., Shi, L., Chen, T., & Wu, Y. (2016) · International Journal of Cancer · doi:10.1002/ijc.30168 · Cited by 176 · see citing works
Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients
Li, Y.-Y., Ge, Q.-X., Cao, J., Zhou, Y.-J., Du, Y.-L., Shen, B., Wan, Y.-J. Y., & Nie, Y.-Q. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3227 · Cited by 175 · see citing works
A Simple and Novel Fecal Biomarker for Colorectal Cancer: Ratio of Fusobacterium Nucleatum to Probiotics Populations, Based on Their Antagonistic Effect
Guo, S., Li, L., Xu, B., Mang-hui, L., Zeng, Q., Han, X., Ying, X., Wu, Y., Wang, Y., Liu, W., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.289728 · Cited by 171 · see citing works
Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses
Tan, K. H., Seers, C. A., Dashper, S. G., Mitchell, H. L., Pyke, J. S., Meuric, V., Slakeski, N., Cleal, S. M., Chambers, J., McConville, M. J., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003955 · Cited by 136 · see citing works
Integrating Chemical Mutagenesis and Whole-Genome Sequencing as a Platform for Forward and Reverse Genetic Analysis of Chlamydia
Kokes, M., Dunn, J. D., Granek, J. A., Nguyen, B. D., Barker, J. R., Valdivia, R. H., & Bastidas, R. J. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.014 · Cited by 134 · see citing works
Microbial ecosystems therapeutics: a new paradigm in medicine?
Petrof, E., Claud, E. C., Gloor, G. B., & Allen‐Vercoe, E. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0039 · Cited by 124 · see citing works
Diverse Toll-Like Receptors Mediate Cytokine Production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in Macrophages
Park, S.-R., Kim, D., Han, S. H., Kang, M., Lee, J., Jeong, Y. L., Lee, S.-J., Kim, T., Ahn, S., Yoon, J., et al. (2014) · Infection and Immunity · doi:10.1128/iai.01226-13 · Cited by 120 · see citing works
Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum
Liu, L., Tabung, F. K., Zhang, X., Nowak, J. A., Qian, Z. R., Hamada, T., Nevo, D., Bullman, S., Mima, K., Kosumi, K., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.04.030 · Cited by 117 · see citing works
Self-citation
Evolution of Invasion in a Diverse Set of Fusobacterium Species
Manson, A. L., Cochrane, K., Griggs, A. D., Haas, B. J., Abeel, T., Zeng, Q., Nice, J. B., MacDonald, H., Birren, B. W., Berger, B. W., et al. (2014) · mBio · doi:10.1128/mbio.01864-14 · Cited by 111 · see citing works
Complementation of the fadA Mutation in Fusobacterium nucleatum Demonstrates that the Surface-Exposed Adhesin Promotes Cellular Invasion and Placental Colonization
Ikegami, A., Chung, P., & Han, Y. W. (2009) · Infection and Immunity · doi:10.1128/iai.00209-09 · Cited by 105 · see citing works
Dental Flossing and Its Relationship to Transient Bacteremia
Carroll, G. C., & Rj, S. (1980) · Journal of Periodontology · doi:10.1902/jop.1980.51.12.691 · Cited by 102 · see citing works
Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer
Wang, H., Li, L., Guo, S., Zeng, Q., Ning, F., Liu, W., & Zhang, G. (2016) · Scientific Reports · doi:10.1038/srep33440 · Cited by 102 · see citing works
Corncob formation between Fusobacterium nucleatum and Streptococcus sanguis
Lancy, P., DiRienzo, J. M., Appelbaum, B., Rosan, B., & Holt, S. C. (1983) · Infection and Immunity · doi:10.1128/iai.40.1.303-309.1983 · Cited by 101 · see citing works
Current and future biomarkers in colorectal cancer
Zarkavelis, G. (2017) · Annals of Gastroenterology · doi:10.20524/aog.2017.0191 · Cited by 101 · see citing works
Genome-Based Reclassification of Fusobacterium nucleatum Subspecies at the Species Level
Kook, J., Park, S., Lim, Y. K., Cho, E., Jo, E., Roh, H., Shin, Y., Paek, J., Kim, H.-S., Kim, H., et al. (2017) · Current Microbiology · doi:10.1007/s00284-017-1296-9 · Cited by 100 · see citing works
Cellular Components Mediating Coadherence of Candida albicans and Fusobacterium nucleatum
Wu, T., Cen, L., Kaplan, C. W., Zhou, X., Lux, R., Shi, W., & He, X. (2015) · Journal of Dental Research · doi:10.1177/0022034515593706 · Cited by 95 · see citing works
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis in Mice via a Toll-Like Receptor 4/p21-Activated Kinase 1 Cascade
Wu, Y., Wu, J., Chen, T., Li, Q., Peng, W., Li, H., Tang, X., & Fu, X. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-4999-2 · Cited by 94 · see citing works
Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis
Liu, P., Shi, W., Zhu, W., Smith, J. W., Hsieh, S.-L. E., Gallo, R. L., & Huang, C. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.047 · Cited by 90 · see citing works
Localization of the Fusobacterium nucleatum T18 adhesin activity mediating coaggregation with Porphyromonas gingivalis T22
Kinder, S. A., & Holt, S. C. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.3.840-850.1993 · Cited by 87 · see citing works
Identification and characterization of a novel Fusobacterium nucleatum adhesin involved in physical interaction and biofilm formation with Streptococcus gordonii
Lima, B. P., Shi, W., & Lux, R. (2017) · MicrobiologyOpen · doi:10.1002/mbo3.444 · Cited by 87 · see citing works
Phylogenetic analysis of Fusobacterium alocis and Fusobacterium sulci based on 16S rRNA gene sequences: proposal of Filifactor alocis (Cato, Moore and Moore) comb. nov. and Eubacterium sulci (Cato, Moore and Moore) comb. nov.
Jalava, J., & Eerola, E. (1999) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-49-4-1375 · Cited by 83 · see citing works
Streptococcus mutans SpaP binds to RadD of Fusobacterium nucleatum ssp. polymorphum
Guo, L., Shokeen, B., He, X., Shi, W., & Lux, R. (2016) · Molecular Oral Microbiology · doi:10.1111/omi.12177 · Cited by 83 · see citing works
Porphyromonas gingivalis Mediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis
Taxman, D. J., Swanson, K. V., Broglie, P. M., Wen, H., Holley-Guthrie, E., Huang, M. T.-H., Callaway, J., Eitas, T., Duncan, J. A., & Ting, J. P. ‐. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401737 · Cited by 82 · see citing works
Characterization of aid1, a Novel Gene Involved in Fusobacterium nucleatum Interspecies Interactions
Kaplan, A., Kaplan, C. W., He, X., McHardy, I. H., Shi, W., & Lux, R. (2014) · Microbial Ecology · doi:10.1007/s00248-014-0400-y · Cited by 77 · see citing works
Arginine-Ornithine Antiporter ArcD Controls Arginine Metabolism and Interspecies Biofilm Development of Streptococcus gordonii
Sakanaka, A., Kuboniwa, M., Takeuchi, H., Hashino, E., & Amano, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.644401 · Cited by 76 · see citing works
Attachment of Fusobacterium nucleatum PK1594 to mammalian cells and its coaggregation with periodontopathogenic bacteria are mediated by the same galactose‐binding adhesin
Weiss, E. I., Shaniztki, B., Dotan, M., Ganeshkumar, N., Kolenbrander, P. E., & Metzger, Z. (2000) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.2000.150606.x · Cited by 73 · see citing works
Phylogeny and molecular signatures for the phylum Fusobacteria and its distinct subclades
Gupta, R. S., & Sethi, M. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.06.007 · Cited by 66 · see citing works
Sonoporation Is an Efficient Tool for Intracellular Fluorescent Dextran Delivery and One-Step Double-Crossover Mutant Construction in Fusobacterium nucleatum
Han, Y. W., Ikegami, A., Chung, P., et al. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00428-07 · Cited by 66 · see citing works
Forward Genetic Dissection of Biofilm Development by Fusobacterium nucleatum: Novel Functions of Cell Division Proteins FtsX and EnvC
Wu, C., Mamun, A. A. M. A., Luong, T. T., Hu, B., Gu, J., Lee, J. H., D’Amore, M., Das, A., & Ton‐That, H. (2018) · mBio · doi:10.1128/mbio.00360-18 · Cited by 66 · see citing works
Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Repass, J. F., Reproducibility Project: Cancer Biology, Iorns, E. J., Denis, A., Williams, S. R., Perfito, N., & Errington, T. M. (2018) · eLife · doi:10.7554/elife.25801 · Cited by 63 · see citing works
Synergistic Pathogenicity of Porphyromonas gingivalis and Fusobacterium nucleatum in the Mouse Subcutaneous Chamber Model
Metzger, Z., Lin, Y., Dimeo, F., Ambrose, W. W., Trope, M., & Arnold, R. R. (2008) · Journal of Endodontics · doi:10.1016/j.joen.2008.10.015 · Cited by 62 · see citing works
Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts
Saitô, A., Kokubu, E., Inagaki, S., Imamura, K., Kita, D., Lamont, R. J., & Ishihara, K. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.08.005 · Cited by 61 · see citing works
Psychrilyobacter atlanticus gen. nov., sp. nov., a marine member of the phylum Fusobacteria that produces H2 and degrades nitramine explosives under low temperature conditions
Zhao, J.-S., Manno, D., & Hawari, J. A.-A. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65263-0 · Cited by 61 · see citing works
Helicobacter pylori and Esophageal Disease: Wake-up Call?
Blaser, M. J. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.037 · Cited by 60 · see citing works
Leveraging Existing 16S rRNA Gene Surveys To Identify Reproducible Biomarkers in Individuals with Colorectal Tumors
Sze, M. A., & Schloss, P. D. (2018) · mBio · doi:10.1128/mbio.00630-18 · Cited by 55 · see citing works
Fusobacterium nucleatum Envelope Protein FomA Is Immunogenic and Binds to the Salivary Statherin-Derived Peptide
Nakagaki, H., Sekine, S., Terao, Y., Toe, M., Tanaka, M., Ito, H., Kawabata, S., Shizukuishi, S., Fujihashi, K., & Kataoka, K. (2009) · Infection and Immunity · doi:10.1128/iai.01224-09 · Cited by 53 · see citing works
Fusobacterial brain abscess: a review of five cases and an analysis of possible pathogenesis
Han, X. Y., Weinberg, J. S., Prabhu, S. S., Hassenbusch, S. J., Fuller, G. N., Tarrand, J. J., & Kontoyiannis, D. P. (2003) · Journal of neurosurgery · doi:10.3171/jns.2003.99.4.0693 · Cited by 52 · see citing works
Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis
Park, J., Shokeen, B., Haake, S. K., & Lux, R. (2016) · International Journal of Oral Science · doi:10.1038/ijos.2016.27 · Cited by 50 · see citing works
Intracellular replication of fusobacteria requires new actin filament formation of epithelial cells
Gürsoy, U. K., Könönen, E., & Uitto, V.-J. (2008) · Apmis · doi:10.1111/j.1600-0463.2008.00868.x · Cited by 49 · see citing works
Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Repass, J. F., Maherali, N., Owen, K. A., & Reproducibility Project: Cancer Biology (2016) · eLife · doi:10.7554/elife.10012 · Cited by 46 · see citing works
FAD-I, a Fusobacterium nucleatum Cell Wall-Associated Diacylated Lipoprotein That Mediates Human Beta Defensin 2 Induction through Toll-Like Receptor-1/2 (TLR-1/2) and TLR-2/6
Bhattacharyya, S., Ghosh, S. K., Shokeen, B., Eapan, B., Lux, R., Kiselar, J., Nithianantham, S., Young, A., Pandiyan, P., McCormick, T. S., et al. (2016) · Infection and Immunity · doi:10.1128/iai.01311-15 · Cited by 46 · see citing works
Proteomics of Fusobacterium nucleatum within a model developing oral microbial community
Hendrickson, E. L., Wang, T., Beck, D. A. C., Dickinson, B. C., Wright, C. J., Lamont, R. J., & Hackett, M. (2014) · MicrobiologyOpen · doi:10.1002/mbo3.204 · Cited by 45 · see citing works
Clinicopathologic considerations of fusobacteria chorioamnionitis
Altshuler, G. P., & Hyde, S. (1988) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348809029862 · Cited by 40 · see citing works
Efficient gene transfer and targeted mutagenesis in Fusobacterium nucleatum
Haake, S. K., Yoder, S. C., & Gerardo, S. H. (2005) · Plasmid · doi:10.1016/j.plasmid.2005.06.002 · Cited by 39 · see citing works
A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum
Casasanta, M. A., Yoo, C. C., Smith, H. B., Duncan, A. J., Cochrane, K., Varano, A. C., Allen‐Vercoe, E., & Slade, D. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.819144 · Cited by 39 · see citing works
Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection
Ahn, S. H., Chun, S., Park, C., Lee, J., Lee, S.-W., & Lee, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188755 · Cited by 39 · see citing works
Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
Zanzoni, A., Spinelli, L., Braham, S., & Brun, C. (2017) · Microbiome · doi:10.1186/s40168-017-0307-1 · Cited by 38 · see citing works
Gal-GalNAc: a biomarker of colon carcinogenesis.
Yang, G., & Shamsuddin, A. M. (1996) · PubMed · Cited by 34 · see citing works
Diagnostic Performance of Intestinal Fusobacterium nucleatum in Colorectal Cancer
Peng, B., Cao, C.-Y., Li, W., Zhou, Y., Zhang, Y., Nie, Y., Cao, Y., & Li, Y. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.232814 · Cited by 30 · see citing works
Fusobacterium nucleatum pericarditis
Truant, A. L., Menge, S., Milliorn, K., et al. (1983) · Journal of Clinical Microbiology · doi:10.1128/jcm.17.2.349-351.1983 · Cited by 29 · see citing works
Fusobacterium nucleatum Subspecies Identification by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry
Nie, S., Tian, B., Wang, X., Pincus, D., Welker, M., Gilhuley, K. A., Lu, X., Han, Y. W., & Tang, Y. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.00239-15 · Cited by 28 · see citing works
Halitosis Vaccines Targeting FomA, a Biofilm-bridging Protein of Fusobacteria nucleatum
Liu, P., Huang, I., Shu, C., et al. (2013) · Current Molecular Medicine · doi:10.2174/15665240113139990063 · Cited by 27 · see citing works
Helicobacter pylori eradication and its implications for the future
BLASER, M. J. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.11.s1.7.x · Cited by 26 · see citing works
Fusobacterium Genomics Using MinION and Illumina Sequencing Enables Genome Completion and Correction
Todd, S. M., Settlage, R. E., Lahmers, K. K., & Slade, D. J. (2018) · mSphere · doi:10.1128/msphere.00269-18 · Cited by 26 · see citing works
Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract
Guo, S., Wang, H., Nian, Z., Wang, Y.-D., Zeng, Q., & Zhang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-11127-x · Cited by 25 · see citing works
FusoPortal: an Interactive Repository of Hybrid MinION-Sequenced Fusobacterium Genomes Improves Gene Identification and Characterization
Sanders, B. E., Umaña, A., Lemkul, J. A., & Slade, D. J. (2018) · mSphere · doi:10.1128/msphere.00228-18 · Cited by 22 · see citing works
Fusobacterium nucleatum T18 Aggregates Human Mononuclear Cells and Inhibits Their PHA‐Stimulated Proliferation
Haake, S. K., & Lindemann, R. A. (1997) · Journal of Periodontology · doi:10.1902/jop.1997.68.1.39 · Cited by 21 · see citing works
The Protective Effect of Recombinant FomA-expressing Lactobacillus acidophilus Against Periodontal Infection
Ma, L., Ding, Q., Feng, X., & Li, F. (2013) · Inflammation · doi:10.1007/s10753-013-9651-x · Cited by 16 · see citing works
Fusobacterium nucleatumOsteomyelitis in 3 Previously Healthy Children: A Case Series and Review of the Literature
Gregory, S. W., Boyce, T. G., Larson, A. N., et al. (2015) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piv052 · Cited by 16 · see citing works
Fecal fusobacterium nucleatum for detecting colorectal cancer: a systematic review and meta-analysis
Huang, Q., Peng, Y., & Xie, F. (2018) · The International Journal of Biological Markers · doi:10.1177/1724600818781301 · Cited by 16 · see citing works
Enteroviral Meningoencephalitis Complicated by Central Diabetes Insipidus in a Neonate: A Case Report and Review of the Literature
Jones, G., Muriello, M. J., Patel, A. L., et al. (2013) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/pit055 · Cited by 15 · see citing works
A preliminary investigation into biosecurity treatments to manage the invasive killer shrimp (Dikerogammarus villosus)
Sebire, M., Rimmer, G. S. E., Hicks, R., Parker, S.-J., & Stebbing, P. (2018) · Management of Biological Invasions · doi:10.3391/mbi.2018.9.2.04 · Cited by 14 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[86]Bennett JE, Dolin R & Blaser MJ Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Disease (Elsevier Health Sciences, 2014).

Sorted by citations

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression
Parhi, L., Alon-Maimon, T., Sol, A., Nejman, D., Shhadeh, A., Fainsod-Levi, T., Yajuk, O., Isaacson, B., Abed, J., Maalouf, N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16967-2 · Cited by 716 · see citing works
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer
Chattopadhyay, I., Verma, M., & Panda, M. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033819867354 · Cited by 407 · see citing works
“FadA adhesion molecule of F nucleatum binds to E-cadherin and activates b-catenin signaling that regulates cell proliferation and inflammatory responses in oncogenesis (Figure 2).(94,104,105) Fusobacterium nucleatum synergistically with other bacteria fungi and viruses may induce proinflammatory microenvironment throu…”
Background
Dysbiosis of human gut microbiome in young-onset colorectal cancer
Yang, Y., Du, L., Shi, D., Kong, C., Liu, J., Liu, G., Li, X., & Ma, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-27112-y · Cited by 303 · see citing works
A rooted phylogeny resolves early bacterial evolution
Coleman, G. A., Davín, A. A., Mahendrarajah, T. A., Szánthó, L. L., Spang, A., Hugenholtz, P., Szöllősi, G. J., & Williams, T. A. (2021) · Science · doi:10.1126/science.abe0511 · Cited by 285 · see citing works
Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer
Gaiser, R. A., Halimi, A., Alkharaan, H., Lu, L., Davanian, H., Healy, K., Hugerth, L. W., Ateeb, Z., Valente, R., Fernández Moro, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317458 · Cited by 227 · see citing works
Oral microbiome: possible harbinger for children’s health
Xiao, J., Fiscella, K. A., & Gill, S. R. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0082-x · Cited by 223 · see citing works
Colorectal cancer: the facts in the case of the microbiota
Clay, S. L., Fonseca-Pereira, D., & Garrett, W. S. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155101 · Cited by 166 · see citing works
Self-citation
Untitled work
Piccinno (2025) · doi:10.1038/s41591-025-03693-9 · Cited by 133 · see citing works
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding
Jans, M., Kolata, M., Blancke, G., D’Hondt, A., Gräf, C., Ciers, M., Sze, M., Thiran, A., Petta, I., Andries, V., et al. (2024) · Nature · doi:10.1038/s41586-024-08135-z · Cited by 84 · see citing works
Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis
Borozan, I., Zaidi, S. H., Harrison, T. A., Phipps, A. I., Zheng, J., Lee, S., Trinh, Q. M., Steinfelder, R. S., Adams, J., Banbury, B. L., et al. (2022) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0463 · Cited by 57 · see citing works
Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development
Gao, Z., Jiang, A., Li, Z., Zhu, L., Mou, W., Shen, W., Luo, P., Tang, B., Zhang, J., & Lin, A. (2025) · Med Research · doi:10.1002/mdr2.70006 · Cited by 51 · see citing works
Coaggregation of oral pathogens by postbiotic lactobacilli
Golletz, P., Jensen, S. D., Collignon, M., Hall, C., Khamas, A. B., Møllebjerg, A., Schlafer, S., Meyer, R. L., & Tykwinska, K. (2025) · Journal of oral microbiology · doi:10.1080/20002297.2025.2508483 · Cited by 10 · see citing works
“…multi-species coaggregation interactions [20,21] that usually resides in the middle of dental biofilms where it bridges early and late colonizers [22], and recruits (2) Porphyromonas gingivalis and (3) Prevotella intermedia both of which possess with its wide range of virulence factors, which…”
Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces
Di Pierro, F., Sagheddu, V., Galletti, S., Casaroli, A., Labrini, E., Soldi, S., Cazzaniga, M., Bertuccioli, A., Matera, M., Cavecchia, I., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10522-5 · Cited by 5 · see citing works
“Studies on the gut microbiota have recently provided strong evidence of the involvement of intestinal oncobacteria such as F. nucleatum , enterotoxigenic B. fragilis , and pathogenic E. coli strains [149–152].”
Chitooligosaccharides improves intestinal mucosal immunity and intestinal microbiota in blue foxes
Wei, J., Su, J., Wang, G., Li, W., Wen, Z., & Liu, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1506991 · Cited by 2 · see citing works

Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System
Abed, J., Maalouf, N., Manson, A. L., Earl, A. M., Parhi, L., Emgård, J., Klutstein, M., Tayeb, S., Almogy, G., Atlan, K., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00400 · Cited by 269 · see citing works
Self-citation
Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc
Abed, J., Emgård, J. E. M., Zamir, G., Faroja, M., Almogy, G., Grenov, A., Sol, A., Naor, R., Pikarsky, E., Atlan, K. A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.006 · Cited by 888 · see citing works
Self-citation
Abstract 5129: Fusobacterium and co-occurring microbes in primary and metastatic colorectal cancer
Bullman, S., Pedamallu, C. S., Sicińska, E., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-5129 · Cited by 3 · see citing works
Fusobacterium nucleatum ATCC 10953 Requires Actinomyces naeslundii ATCC 43146 for Growth on Saliva in a Three-Species Community That Includes Streptococcus oralis 34
Periasamy, S., Chalmers, N. I., Du‐Thumm, L., & Kolenbrander, P. E. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02901-08 · Cited by 79 · see citing works
Identification and Characterization of a Novel Adhesin Unique to Oral Fusobacteria
Han, Y. W., Ikegami, A., Rajanna, C., Kawsar, H. I., Zhou, Y., Li, M., Sojar, H. T., Genco, R. J., Kuramitsu, H. K., & Deng, C. X. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.15.5330-5340.2005 · Cited by 260 · see citing works

Authors: Brennan, C. A., & Garrett, W. S.
Affiliations: Harvard University (US)
Corresponding author: Garrett, Wendy S.
ORCID: Brennan, Caitlin A.
Garrett, Wendy S.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2018-12-13
Volume: 17
Issue: 3
Pages: 156-166
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/s41579-018-0129-6
PMC: PMC6589823
OpenAlex: W2904988746
Cited by: 1,205
References: 128
Citations by year: 2026: 150 · 2025: 196 · 2024: 242 · 2023: 182 · 2022: 165 · 2021: 137 · 2020: 101 · 2019: 29 · 2018: 1 · 2016: 1
FWCI: 9.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (T32CA207021, R01CA154426)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: Fusobacterium nucleatum, Fusobacteria, oral microbiota, symbiosis, opportunistic infections, colorectal cancer, bacterial diversity, host-microbe interactions, cancer diagnosis, cancer therapeutics
MeSH terms: Host Microbial Interactions, Fusobacterium Infections, Humans, Mouth, Symbiosis, Colorectal Neoplasms, Fusobacterium nucleatum, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fusobacterium nucleatum — symbiont, opportunist and oncobacterium

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks