The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Muscle abnormalities worsen after post-exertional malaise in long COVID
Open accessAbstract
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases.
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Cites
Distribution Theory for Glass's Estimator of Effect Size and Related Estimators
Hedges, L. V. (1981) · Journal of Educational Statistics · doi:10.2307/1164588 · Cited by 5,695
cocor: A Comprehensive Solution for the Statistical Comparison of Correlations
Diedenhofen, B., & Musch, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0121945 · Cited by 1,919
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
Wang, Z., Muecksch, F., Schaefer-Babajew, D., Finkin, S., Viant, C., Gaebler, C., Hoffmann, H. H., Barnes, C. O., Cipolla, M., Ramos, V., et al. (2021) · Nature · doi:10.1038/s41586-021-03696-9 · Cited by 721
Frésard, I., Genecand, L., Altarelli, M., Gex, G., Vremaroiu, P., Vremaroiu-Coman, A., Lawi, D., & Bridevaux, P.-O. (2022) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2021-001126 · Cited by 113
Cited by
Long COVID science, research and policy
Al-Aly, Z., Davis, H., McCorkell, L., Soares, L., Wulf-Hanson, S., Iwasaki, A., & Topol, E. J. (2024) · Nature Medicine · doi:10.1038/s41591-024-03173-6 · Cited by 538
Greenhalgh, T., Sivan, M., Perlowski, A., & Nikolich, J. Ž. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01136-x · Cited by 502
Mechanisms of long COVID and the path toward therapeutics
Peluso, M. J., & Deeks, S. G. (2024) · Cell · doi:10.1016/j.cell.2024.07.054 · Cited by 341
Metadata
- Authors
- Appelman, B., Charlton, B. T., Goulding, R. P., Kerkhoff, T. J., Breedveld, E. A., Noort, W., Offringa, C., Bloemers, F. W., van Weeghel, M., Schomakers, B. V., Coelho, P., Posthuma, J. J., Aronica, E., Joost Wiersinga, W., van Vugt, M., & Wüst, R. C. I.
- Venue
- Nature Communications
- Published
- 2024-01-04
- Volume
- 15
- Issue
- 1
- Pages
- 17-17
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4390582057
- Cited by
- 360
- References
- 4
- FWCI
- 82.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Appelman, B., Charlton, B. T., Goulding, R. P., Kerkhoff, T. J., Breedveld, E. A., Noort, W., Offringa, C., Bloemers, F. W., van Weeghel, M., Schomakers, B. V., Coelho, P., Posthuma, J. J., Aronica, E., Joost Wiersinga, W., van Vugt, M., & Wüst, R. C. I. (2024). Muscle abnormalities worsen after post-exertional malaise in long COVID. Nature Communications. https://doi.org/10.1038/s41467-023-44432-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
