Cited by 117Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthChronic Disease Management Strategies

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Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity

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Zhao, Yimin, Zhuang, Zhenhuang, Li, Yueying, Xiao, Wendi, Song, Zimin, Huang, Ninghao, Wang, Wenxiu, Dong, Xue, Jia, Jinzhu, Clarke, Robert, Huang, Tao·2024·Nature Communications

DOI 10.1038/s41467-024-46686-xPMC PMC10951224

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Abstract

The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two of type 2 diabetes, ischemic heart disease, and stroke, has not been definitively established. We aim to examine the prospective associations between serum remnant cholesterol, triglycerides, and the risks of progression from first cardiometabolic disease to multimorbidity via multistate modeling in the UK Biobank. We also evaluate the causality of these associations via Mendelian randomization using 13 biologically relevant SNPs as the genetic instruments. Here we show that elevated remnant cholesterol and triglycerides are significantly associated with gradually higher risks of cardiometabolic multimorbidity, particularly the progression of ischemic heart disease to the multimorbidity of ischemic heart disease and type 2 diabetes. These results advocate for effective management of remnant cholesterol and triglycerides as a potential strategy in mitigating the risks of cardiometabolic multimorbidity.

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Fig. 1 Genetic associations between remnant cholesterol, triglycerides, and cardiometabolic multimorbidity via one-sample Mendelian randomization among the UK Biobank participants (n = 376,712 for remnant cholesterol and n = 411,930 for triglycerides). Causal odds ratios were calculated adjusting for age and sex. Data are presented as odd ratios with 95% confidence intervals. The dot refers to the odd ratio while the solid line refers to the 95% confidence interval. The dash line refers to odd ratio value of one as the reference. Abbreviations: CI confidence interval, IHD ischemic heart disease, OR odds ratio, T2D type 2 diabetes. Statistical significance is set at two-sided P value < 0.05.CC BY · PubMed Central

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Authors: Zhao, Y., Zhuang, Z., Li, Y., Xiao, W., Song, Z., Huang, N., Wang, W., Dong, X., Jia, J., Clarke, R., & Huang, T.
Affiliations: Peking University (CN)
University of Oxford (GB)
Ministry of Education of the People's Republic of China (CN)
Corresponding author: Huang, Tao
ORCID: Zhao, Yimin
Zhuang, Zhenhuang
Li, Yueying
Xiao, Wendi
Song, Zimin
Huang, Ninghao
Wang, Wenxiu
Jia, Jinzhu
Clarke, Robert
Huang, Tao
Venue: Nature Communications
Publisher: Springer Science and Business Media LLC
Published: 2024-03-19
Volume: 15
Issue: 1
Pages: 2451-2451
ISSN: 2041-1723 (ISSN-L)
DOI: 10.1038/s41467-024-46686-x
PMC: PMC10951224
OpenAlex: W4392954776
Cited by: 117
References: 53
Citations by year: 2026: 52 · 2025: 47 · 2024: 17
FWCI: 38.20
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Nature Communications (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (82173499, 82204026)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Keywords: remnant cholesterol, triglycerides, cardiometabolic multimorbidity, type 2 diabetes, ischemic heart disease, stroke, triglyceride-rich lipoproteins, disease progression, multi-state models, Mendelian randomization, genetic instruments, causal inference
MeSH terms: Multimorbidity, Cholesterol, Diabetes Mellitus, Type 2, Humans, Hypercholesterolemia, Risk Factors, Triglycerides, Myocardial Ischemia

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Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity

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