Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Abstract
Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only revealed a relationship between plasma triglyceride levels and the risk of atherosclerotic cardiovascular disease, but have also identified key proteins responsible for the regulation of triglyceride transport. Kinetic studies in humans using stable isotope tracers have been especially useful in delineating the function of these proteins and revealing the hitherto unappreciated complexity of triglyceride-rich lipoprotein metabolism. Given that triglyceride is an essential energy source for mammals, triglyceride transport is regulated by numerous mechanisms that balance availability with the energy demands of the body. Ongoing investigations are focused on determining the consequences of dysregulation as a result of either dietary imprudence or genetic variation that increases the risk of atherosclerosis and pancreatitis. The identification of molecular control mechanisms involved in triglyceride metabolism has laid the groundwork for a 'precision-medicine' approach to therapy. Novel pharmacological agents under development have specific molecular targets within a regulatory framework, and their deployment heralds a new era in lipid-lowering-mediated prevention of disease. In this Review, we outline what is known about the dysregulation of triglyceride transport in human hypertriglyceridaemia.
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A decrease of 1 mmol/L (88.57 mg/dL) in triglycerides has been linked to roughly a 25% reduction in cardiovascular disease risk.
“A decrease of 1 mmol/L (88.57 mg/dL) in triglycerides has been linked to roughly a 25% reduction in cardiovascular disease risk [24, 25]”
From Ketogenic diet-induced changes in adult lipid metabolism: a comprehensive systematic review and meta-regression of randomized controlled trials (2026) · cites this paper as [24]
In the postprandial state, CM are assembled in enterocytes through packaging of dietary TG, cholesterol, and apolipoprotein B48.
“In the postprandial state, CM are assembled in enterocytes through the packaging of dietary TG, cholesterol, and apolipoprotein B48 [10].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [10]
Hepatocytes continuously secrete VLDL particles containing apolipoprotein B100, incorporating TG derived from de novo lipogenesis, circulating non-esterified fatty acids, hepatic lipid stores, and remnant uptake.
“In parallel, hepatocytes continuously secrete VLDL particles containing apolipoprotein B100, incorporating TG derived from de novo lipogenesis, circulating non-esterified fatty acids, hepatic lipid stores, and remnant uptake [10].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [10]
TRLs, primarily chylomicrons and VLDL, are secreted by the intestine and liver, respectively, and are the main vehicles for TG transport in the circulation.
“TRLs, primarily chylomicrons (CM) and very low-density lipoproteins (VLDL), are secreted by the intestine and liver, respectively, and are the main vehicles for TG transport in the circulation.”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [10]
Cites
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961 · see citing works
Self-citationMach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854 · see citing works
Self-citation(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317 · see citing works
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001282 · Cited by 2,837 · see citing works
Major lipids, apolipoproteins, and risk of vascular disease
The Emerging Risk Factors Collaboration* (2009) · JAMA · doi:10.1001/jama.2009.1619 · Cited by 2,731 · see citing works
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002 · see citing works
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772 · see citing works
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701 · see citing works
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601 · see citing works
Self-citationNewly identified loci that influence lipid concentrations and risk of coronary artery disease
Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585 · see citing works
Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399 · see citing works
Self-citationDietary fats and cardiovascular disease: a presidential advisory from the American Heart Association
Sacks, F. M., Lichtenstein, A. H., Wu, J. H. Y., Appel, L. J., Creager, M. A., Kris-Etherton, P. M., Miller, M., Rimm, E. B., Rudel, L. L., Robinson, J. G., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000510 · Cited by 1,386 · see citing works
Goldstein, J. L., & Brown, M. S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179564 · Cited by 1,344 · see citing works
Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227 · see citing works
Self-citation2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.009 · Cited by 1,193 · see citing works
Nordestgaard, B. G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306249 · Cited by 1,116 · see citing works
Loss-of-Function Mutations in <i>APOC3,</i> Triglycerides, and Coronary Disease
The TG and HDL Working Group of the Exome Sequencing Project, N. H. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307095 · Cited by 1,071 · see citing works
Nicholls, S. J., Lincoff, A. M., Garcia, M., Bash, D., Ballantyne, C. M., Barter, P. J., Davidson, M. H., Kastelein, J. J. P., Koenig, W., McGuire, D. K., et al. (2020) · JAMA · doi:10.1001/jama.2020.22258 · Cited by 1,028 · see citing works
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019 · see citing works
Self-citationGinsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab551 · Cited by 979 · see citing works
Self-citationKotseva, K., Backer, G. D., Bacquer, D. D., Rydén, L., Hoes, A. W., Grobbee, D. E., Maggioni, A. P., Marques-Vidal, P. M., Jennings, C. S., Abreu, A., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487318825350 · Cited by 940 · see citing works
Loss-of-Function Mutations in <i>APOC3</i> and Risk of Ischemic Vascular Disease
Jørgensen, A. B., Frikke-Schmidt, R., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308027 · Cited by 919 · see citing works
Diabetic dyslipidaemia: from basic research to clinical practice*
Taskinen, M.-R. (2003) · Diabetologia · doi:10.1007/s00125-003-1111-y · Cited by 888 · see citing works
Self-citationGenetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Dewey, F. E., Gusarova, V., Dunbar, R. L., O’Dushlaine, C., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612790 · Cited by 885 · see citing works
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 862 · see citing works
Evinacumab for Homozygous Familial Hypercholesterolemia
Raal, F. J., Rosenson, R. S., Reeskamp, L. F., Hovingh, G. K., Kastelein, J. J. P., Rubba, P., Ali, S., Banerjee, P., Chan, K.-C., Gipe, D. A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2004215 · Cited by 793 · see citing works
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771 · see citing works
Exome Sequencing, <i>ANGPTL3</i> Mutations, and Familial Combined Hypolipidemia
Musunuru, K., Pirruccello, J. P., Do, R., Peloso, G. M., Guiducci, C., Sougnez, C., Garimella, K. V., Fisher, S., Abreu, J., Barry, A. J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002926 · Cited by 754 · see citing works
Plasma triglyceride and coronary heart disease
Austin, M. A. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.1.2 · Cited by 697 · see citing works
Overproduction of large VLDL particles is driven by increased liver fat content in man
Adiels, M., Taskinen, M.-R., Packard, C., Caslake, M. J., Soro-Paavonen, A., Westerbacka, J., Vehkavaara, S., Häkkinen, A., Olofsson, S.-O., Yki-Järvinen, H., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0125-z · Cited by 690 · see citing works
Self-citationCeriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R., & Motz, E. (2002) · Circulation · doi:10.1161/01.cir.0000027569.76671.a8 · Cited by 655 · see citing works
Dysregulated lipid metabolism links NAFLD to cardiovascular disease
Deprince, A., Haas, J. T., & Staels, B. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101092 · Cited by 558 · see citing works
Scott, R., O'Brien, R., Fulcher, G., Pardy, C., d'Emden, M., Tse, D., Taskinen, M.-R., Ehnholm, C., Keech, A., & on behalf of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators (2009) · Diabetes Care · doi:10.2337/dc08-1543 · Cited by 551 · see citing works
Self-citationRole of Estrogens in the Regulation of Liver Lipid Metabolism
Palmisano, B. T., Zhu, L., & Stafford, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_12 · Cited by 550 · see citing works
Physiological regulation of lipoprotein lipase
Kersten, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.013 · Cited by 548 · see citing works
Clinical review on triglycerides
Laufs, U., Parhofer, K. G., Ginsberg, H. N., & Hegele, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz785 · Cited by 544 · see citing works
Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3
Jong, M. C., Hofker, M. H., & Havekes, L. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.3.472 · Cited by 539 · see citing works
Exome-wide association study of plasma lipids in >300,000 individuals
Charge Diabetes Working Group, Liu, D. J., Program, V. M. V., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X. Q., Mahajan, A., Saleheen, D., Emdin, C. A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3977 · Cited by 538 · see citing works
Lewis, G., Uffelman, K., Szeto, L., Weller, B., & Steiner, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117633 · Cited by 533 · see citing works
Romeo, S., Pennacchio, L. A., Fu, Y., Boerwinkle, E., Tybjaerg-Hansen, A., Hobbs, H. H., & Cohen, J. C. (2007) · Nature Genetics · doi:10.1038/ng1984 · Cited by 511 · see citing works
Hepatic uptake of chylomicron remnants
Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499 · see citing works
Inactivating Variants in <i>ANGPTL4</i> and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497 · see citing works
Targeting APOC3 in the familial chylomicronemia syndrome
Gaudet, D., Brisson, D., Tremblay, K., Alexander, V. J., Singleton, W., Hughes, S. G., Geary, R. S., Baker, B. F., Graham, M. J., Crooke, R. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1400284 · Cited by 491 · see citing works
Beigneux, A. P., Davies, B. S. J., Gin, P., Weinstein, M. M., Farber, E., Qiao, X., Peale, F. V., Jr., Bunting, S., Walzem, R. L., Wong, J. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.002 · Cited by 470 · see citing works
ANGPTL3 deficiency and protection against coronary artery disease
Stitziel, N. O., Khera, A. V., Wang, X., Bierhals, A. J., Vourakis, A. C., Sperry, A. E., Natarajan, P., Klarin, D., Emdin, C. A., Zekavat, S. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.030 · Cited by 467 · see citing works
Fisher, E. A. A., & Ginsberg, H. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100068200 · Cited by 459 · see citing works
New insights into the pathophysiology of dyslipidemia in type 2 diabetes
Taskinen, M.-R., & Borén, J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.039 · Cited by 440 · see citing works
Self-citationRomeo, S., Wu, Y., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H., & Cohen, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37118 · Cited by 422 · see citing works
Angptl3 regulates lipid metabolism in mice
Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., & Furukawa, H. (2002) · Nature Genetics · doi:10.1038/ng814 · Cited by 420 · see citing works
IDIOPATHIC HYPERLIPEMIA: METABOLIC STUDIES IN AN AFFECTED FAMILY*
Havel, R. J., & Gordon, R. S. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104202 · Cited by 380 · see citing works
PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells
Lagace, T. A. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000114 · Cited by 372 · see citing works
Johannesen, C. D. L., Mortensen, M. B., Langsted, A., & Nordestgaard, B. G. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.027 · Cited by 359 · see citing works
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
Huang, L., Chambliss, K. L., Gao, X., Yuhanna, I. S., Behling‐Kelly, E. L., Bergaya, S., Ahmed, M. H., Michaely, P., Luby‐Phelps, K., Darehshouri, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1140-4 · Cited by 354 · see citing works
Olofsson, S. ‐., & Borén, J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01556.x · Cited by 328 · see citing works
Self-citationBorén, J., Olin, K., Lee, I., Chait, A., Wight, T. N., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2265 · Cited by 320 · see citing works
Self-citationPradhan, A. D., Paynter, N. P., Everett, B. M., Glynn, R. J., Amarenco, P., Elam, M., Ginsberg, H., Hiatt, W. R., Ishibashi, S., Koenig, W., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.09.011 · Cited by 319 · see citing works
Apolipoprotein B: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation
Davidson, N. O., & Shelness, G. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.169 · Cited by 311 · see citing works
Marston, N. A., Giugliano, R. P., Im, K., Silverman, M. G., O’Donoghue, M. L., Wiviott, S. D., Ference, B. A., & Sabatine, M. S. (2019) · Circulation · doi:10.1161/circulationaha.119.041998 · Cited by 301 · see citing works
Packard, C. J., Munro, A. F., Lorimer, A. R., Gotto, A. M., & Shepherd, J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111644 · Cited by 298 · see citing works
Self-citationShimamura, M., Matsuda, M., Yasumo, H., Okazaki, M., Fujimoto, K., Kono, K., Shimizugawa, T., Ando, Y., Koishi, R., Kohama, T., et al. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000252827.51626.89 · Cited by 297 · see citing works
Gaudet, D., Karwatowska-Prokopczuk, E., Baum, S. J., Hurh, E., Kingsbury, J., Bartlett, V. J., Figueroa, A. L., Piscitelli, P., Singleton, W., Witztum, J. L., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa689 · Cited by 279 · see citing works
Barrows, B. R., & Parks, E. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1709 · Cited by 273 · see citing works
Nonfasting mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis
Pedersen, S. B., Langsted, A., & Nordestgaard, B. G. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.6875 · Cited by 270 · see citing works
Morrone, D., Weintraub, W. S., Toth, P. P., Hanson, M. E., Lowe, R. S., Lin, J., Shah, A. K., & Tershakovec, A. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.016 · Cited by 263 · see citing works
Schneeman, B. O., Kotite, L., Todd, K., & Havel, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2069 · Cited by 255 · see citing works
Semenkovich, C. F., Wims, M., Noé, L., Étienne, J., & Chan, L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81898-1 · Cited by 249 · see citing works
Cohn, J. S., Johnson, E. J., Millar, J. S., Cohn, S. D., Milne, R. W., Marcel, Y. L., Russell, R. M., & Schaefer, E. J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35345-1 · Cited by 248 · see citing works
Moulin, P., Dufour, R., Averna, M., Arca, M., Cefalù, A. B., Noto, D., D'Erasmo, L., Di Costanzo, A., Marçais, C., Alvarez-Sala Walther, L. A., et al. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.814 · Cited by 247 · see citing works
Self-citationGenetics of hypertriglyceridemia
Dron, J. S., & Hegele, R. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00455 · Cited by 244 · see citing works
Lee, M., Saver, J. L., Towfighi, A., Chow, J., & Ovbiagele, B. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.020 · Cited by 240 · see citing works
Causes and consequences of hypertriglyceridemia
Packard, C. J., Boren, J., & Taskinen, M.-R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00252 · Cited by 239 · see citing works
Self-citationFatty acid control of lipoprotein lipase: a link between energy metabolism and lipid transport
Peterson, J., Bihain, B. E., Bengtsson-Olivecrona, G., Deckelbaum, R. J., Carpentier, Y. A., & Olivecrona, T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.909 · Cited by 237 · see citing works
Borén, J., Lee, I., Zhu, W., Arnold, K. S., Taylor, S., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1847 · Cited by 233 · see citing works
Self-citationCamejo, G. (1982) · Advances in lipid research · doi:10.1016/b978-0-12-024919-0.50007-2 · Cited by 231 · see citing works
Wolska, A., Dunbar, R. L., Freeman, L. A., Ueda, M., Amar, M. J., Sviridov, D. O., & Remaley, A. T. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.025 · Cited by 231 · see citing works
Lipoprotein lipase and its regulators: an unfolding story
Wu, S. A., Kersten, S., & Qi, L. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.11.005 · Cited by 225 · see citing works
Severe hypertriglyceridemia is primarily polygenic
Dron, J. S., Wang, J., Cao, H., McIntyre, A. D., Iacocca, M. A., Menard, J. R., Movsesyan, I., Malloy, M. J., Pullinger, C. R., Kane, J. P., et al. (2019) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2018.10.006 · Cited by 222 · see citing works
Fard, A., Tuck, C. H., Donis, J. A., Sciacca, R. R., Tullio, M. R. D., Wu, H. D., Bryant, T. A., Chen, N.-T., Torres‐Tamayo, M., Ramasamy, R., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2039 · Cited by 221 · see citing works
Angiopoietin-like 3 in lipoprotein metabolism
Kersten, S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.119 · Cited by 220 · see citing works
Lee, J.-H., & Hegele, R. A. (2013) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-013-9665-4 · Cited by 202 · see citing works
Adiels, M., Westerbacka, J., Soro‐Paavonen, A., Häkkinen, A. ‐., Vehkavaara, S., CASLAKE, M. J., Packard, C. J., Olofsson, S.-O., Yki‐Järvinen, H., Taskinen, M., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0790-1 · Cited by 197 · see citing works
Self-citationEffects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.
Malmström, R., Packard, C. J., CASLAKE, M. J., Bedford, D. K., Stewart, P., Yki‐Järvinen, H., Shepherd, J., & Taskinen, M. (1998) · Diabetes · doi:10.2337/diabetes.47.5.779 · Cited by 197 · see citing works
Self-citationThe Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
Borén, J., Packard, C. J., & Taskinen, M.-R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00474 · Cited by 196 · see citing works
Self-citationBruckert, E., Labreuche, J., Deplanque, D., Touboul, P.-J., & Amarenco, P. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318202709f · Cited by 192 · see citing works
Vallejo-Vaz, A. J., Fayyad, R., Boekholdt, S. M., Hovingh, G. K., Kastelein, J. J., Melamed, S., Barter, P., Waters, D. D., & Ray, K. K. (2018) · Circulation · doi:10.1161/circulationaha.117.032318 · Cited by 187 · see citing works
The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
Ginsberg, H. N., & Fisher, E. A. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800090-jlr200 · Cited by 184 · see citing works
Postprandial hypertriglyceridemia as a coronary risk factor
Borén, J., Matikainen, N., Adiels, M., & Taskinen, M.-R. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.01.015 · Cited by 182 · see citing works
Self-citationPostprandial metabolism of meal triglyceride in humans
Lambert, J. E., & Parks, E. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.01.006 · Cited by 182 · see citing works
Metabolic Basis of Hypotriglyceridemic Effects of Insulin in Normal Men
Malmström, R., Packard, C. J., Watson, T. D. G., Rannikko, S., CASLAKE, M. J., Bedford, D. K., Stewart, P., Yki‐Järvinen, H., Shepherd, J., & Taskinen, M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1454 · Cited by 178 · see citing works
Self-citationBalling, M., Afzal, S., Varbo, A., Langsted, A., Davey Smith, G., & Nordestgaard, B. G. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.610 · Cited by 175 · see citing works
Borén, J., Graham, L., WETTESTEN, M., Scott, J., White, A. L., & Olofsson, S. ‐. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50173-9 · Cited by 172 · see citing works
Self-citationPostprandial lipoprotein metabolism: VLDL vs chylomicrons
Nakajima, K., Nakano, T., Tokita, Y., Nagamine, T., Inazu, A., Kobayashi, J., Mabuchi, H., Stanhope, K. L., Havel, P. J., Okazaki, M., et al. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.018 · Cited by 168 · see citing works
Nicholls, S. J., Lincoff, A. M., Bash, D., Ballantyne, C. M., Barter, P. J., Davidson, M. H., Kastelein, J. J. P., Koenig, W., McGuire, D. K., Mozaffarian, D., et al. (2018) · Clinical Cardiology · doi:10.1002/clc.23055 · Cited by 167 · see citing works
Gordon, D. A., Jamil, H., Gregg, R. E., Olofsson, S., & Borén, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.33047 · Cited by 165 · see citing works
Self-citationClinical and biochemical features of different molecular etiologies of familial chylomicronemia
Hegele, R. A., Berberich, A. J., Ban, M. R., Wang, J., Digenio, A., Alexander, V. J., D'Erasmo, L., Arca, M., Jones, A., Bruckert, E., et al. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2018.03.093 · Cited by 165 · see citing works
Wilson, D. E., Emi, M., Iverius, P., Hata, A., Wu, L. L., Hillas, E., Williams, R. R., & Lalouel, J.-M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114770 · Cited by 164 · see citing works
Araki, E., Yamashita, S., Arai, H., Yokote, K., Satoh, J., Inoguchi, T., Nakamura, J., Maegawa, H., Yoshioka, N., Tanizawa, Y., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1589 · Cited by 164 · see citing works
Koo, S., Stoeckman, A. K., & Towle, H. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010029200 · Cited by 160 · see citing works
Mobilisation of enterocyte fat stores by oral glucose in humans
Robertson, M. D., Parkes, M., Warren, B. F., Ferguson, D. J. P., Jackson, K. G., Jewell, D. P., & Frayn, K. N. (2003) · Gut · doi:10.1136/gut.52.6.834 · Cited by 156 · see citing works
Gencer, B., Djousse, L., Al-Ramady, O. T., Cook, N. R., Manson, J. E., & Albert, C. M. (2021) · Circulation · doi:10.1161/circulationaha.121.055654 · Cited by 150 · see citing works
Taskinen, M., & Nikkil�, E. A. (1979) · Diabetologia · doi:10.1007/bf01236268 · Cited by 145 · see citing works
Self-citationFamilial chylomicronemia syndrome: an under‐recognized cause of severe hypertriglyceridaemia
Baass, A., Paquette, M., Bernard, S., & Hegele, R. A. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13016 · Cited by 144 · see citing works
Karpe, F., Bell, M., Björkegren, J., & Hamsten, A. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.2.199 · Cited by 143 · see citing works
Hiukka, A., Ståhlman, M., Pettersson, C., Levin, M. C., Adiels, M., Teneberg, S., Leinonen, E. S., Hultén, L. M., Wiklund, O., Orešič, M., et al. (2009) · Diabetes · doi:10.2337/db09-0206 · Cited by 141 · see citing works
Self-citationGPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism
Young, S. G., Fong, L. G., Beigneux, A. P., Allan, C. M., He, C. H., Jiang, H., Nakajima, K., Muthuraman, M., Birrane, G., & Ploug, M. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.023 · Cited by 141 · see citing works
Lipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis
Schwartz, E. A., & Reaven, P. D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.021 · Cited by 130 · see citing works
Borén, J., WETTESTEN, M., Sjöberg, A., Thorlin, T., Bondjers, G., Wiklund, O., & Olofsson, S. ‐. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86983-6 · Cited by 127 · see citing works
Self-citationIntestinal lipoprotein assembly
Hussain, M. M., Fatma, S., Pan, X., & Iqbal, J. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000169347.53568.5a · Cited by 127 · see citing works
Rustaeus, S., Stillemark-Billton, P., Lindberg, K., Gordon, D., & Olofsson, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5196 · Cited by 126 · see citing works
Flood, C., Gustafsson, M. V., Pitas, R. E., Arnaboldi, L., Walzem, R. L., & Borén, J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000117174.19078.85 · Cited by 125 · see citing works
Self-citationProctor, S. D., & Mamo, J. C. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000084638.14534.0a · Cited by 124 · see citing works
Triacylglycerol hydrolase: role in intracellular lipid metabolism
Dolinsky, V. W., Gilham, D., Alam, M., Vance, D. E., & Lehner, R. S. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3426-3 · Cited by 123 · see citing works
Alcohol-induced changes in serum lipoproteins and in their metabolism.
Taskinen, M.-R., Nikkilä, E. A., Välimäki, M., Sane, T., Kuusi, T., Kesäniemi, Y. A., & Ylikahri, R. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90614-4 · Cited by 122 · see citing works
Self-citationGLP-1 and GLP-2 as Yin and Yang of Intestinal Lipoprotein Production
Hein, G. J., Baker, C., Hsieh, J., Farr, S., & Adeli, K. (2012) · Diabetes · doi:10.2337/db12-0202 · Cited by 121 · see citing works
A Comprehensive Update on the Chylomicronemia Syndrome
Goldberg, R. B., & Chait, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.593931 · Cited by 121 · see citing works
Gilham, D., Ho, S. B., Rasouli, M., Martres, P., Vance, D. E., & Lehner, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0728fje · Cited by 115 · see citing works
Systemic and Forearm Triglyceride Metabolism
Miles, J. M., Park, Y., Walewicz, D., Russell-Lopez, C., Windsor, S. L., Isley, W. L., Coppack, S. W., & Harris, W. S. (2004) · Diabetes · doi:10.2337/diabetes.53.3.521 · Cited by 114 · see citing works
Kirchgessner, T. G., LeBoeuf, R. C., Langner, C., Zollman, S., Chang, C., Taylor, B. A., Schotz, M. C., Gordon, J. I., & Lusis, A. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94212-2 · Cited by 113 · see citing works
Oro-sensory perception of dietary lipids: new insights into the fat taste transduction
Khan, N. A., & Besnard, P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.01.001 · Cited by 111 · see citing works
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans
Wang, X., Wang, H., Xu, B., Huang, D., Nie, C., Pu, L., Zajac, G. J. M., Yan, H., Zhao, J., Shi, F., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.020 · Cited by 111 · see citing works
The Diagnosis and Treatment of Hypertriglyceridemia
Parhofer, K. G., & Laufs, U. (2019) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2019.0825 · Cited by 110 · see citing works
Dynamics of fat absorption and effect of sham feeding on postprandial lipema
Chavez–Jauregui, R. N., Mattes, R. D., & Parks, E. J. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.002 · Cited by 109 · see citing works
Identification of the Proteoglycan Binding Site in Apolipoprotein B48
Flood, C., Gustafsson, M. V., Richardson, P. E., Harvey, S. C., Segrest, J. P., & Borén, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204053200 · Cited by 107 · see citing works
Self-citationRegulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms
Xiao, C., Stahel, P., & Lewis, G. F. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.015 · Cited by 107 · see citing works
Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E. A. A., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(11)70033-2 · Cited by 105 · see citing works
Self-citationIncreased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes
Kanter, J. E., Shao, B., Kramer, F., Barnhart, S., Shimizu‐Albergine, M., Vaisar, T., Graham, M. J., Crooke, R. M., Manuel, C. R., Haeusler, R. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127308 · Cited by 105 · see citing works
Pavlic, M., Xiao, C., Szeto, L., Patterson, B. W., & Lewis, G. F. (2009) · Diabetes · doi:10.2337/db09-1297 · Cited by 102 · see citing works
FoxO1 and hepatic lipid metabolism
Sparks, J. D., & Dong, H. H. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832b3f4c · Cited by 96 · see citing works
Hiukka, A., Fruchart‐Najib, J., Leinonen, E. S., Hilden, H., Fruchart, J., & Taskinen, M. (2005) · Diabetologia · doi:10.1007/s00125-005-1753-z · Cited by 96 · see citing works
Self-citationEffects of ethanol intake on lipoproteins and atherosclerosis.
Brinton, E. A. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833c1f41 · Cited by 95 · see citing works
Determinants of VLDL-triglycerides production
Nielsen, S., & Karpe, F. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283544956 · Cited by 94 · see citing works
New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk
Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 94 · see citing works
A new dawn for managing dyslipidemias: The era of rna-based therapies
Macchi, C., Sirtori, C. R., Corsini, A., Santos, R. D., Watts, G. F., & Ruscica, M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104413 · Cited by 94 · see citing works
Molecular mechanisms of apolipoprotein B mRNA editing
Anant, S., & Davidson, N. O. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00009 · Cited by 91 · see citing works
Borén, J., Rustaeus, S., WETTESTEN, M., Andersson, M., Wiklund, A., & Olofsson, S. ‐. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.12.1743 · Cited by 88 · see citing works
Self-citationRemnant lipoproteins: are they equal to or more atherogenic than LDL?
Salinas, C. A. A., & Chapman, M. J. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000682 · Cited by 87 · see citing works
Doi, T., Langsted, A., & Nordestgaard, B. G. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab555 · Cited by 87 · see citing works
Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics
Julve, J., Martín-Campos, J. M., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.004 · Cited by 85 · see citing works
ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition
Chen, Y., Pottanat, T. G., Zhen, Y., Siegel, R. W., Ehsani, M. E., Qian, Y., & Konrad, R. J. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100068 · Cited by 85 · see citing works
Remnant cholesterol predicts progression of diabetic nephropathy and retinopathy in type 1 diabetes
Sigfrids, F. J., Dahlström, E. H., Forsblom, C. M., Sandholm, N., Harjutsalo, V., Taskinen, M., & Groop, P. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13298 · Cited by 85 · see citing works
Self-citationTremblay, A. J., Lamarche, B., Cohn, J. S., Hogue, J., & Couture, P. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000216750.09611.ec · Cited by 84 · see citing works
Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin
Haridas, P. A. N., Soronen, J., Sädevirta, S., Mysore, R., Quagliarini, F., Pasternack, A. H., Metso, J., Perttilä, J., Leivonen, M., Smas, C. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1254 · Cited by 83 · see citing works
Triglycerides and cardiovascular disease
Esan, O., & Wierzbicki, A. S. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000862 · Cited by 83 · see citing works
Exome-wide association study of plasma lipids in > 300,000 individuals
Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C. A., Alam, D. S., Alves, A. C., et al. (2017) · Figshare · Cited by 82 · see citing works
Martínez‐González, M. Á., Fernandez-Lazaro, C. I., Toledo, E., Díaz‐López, A., Corella, D., Goday, A., Romaguera, D., Vioqué, J., Alonso‐Gómez, Á. M., Wärnberǵ, J., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz298 · Cited by 82 · see citing works
Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans
Borén, J., Adiels, M., Björnson, E., Matikainen, N., Söderlund, S., Rämö, J., Ståhlman, M., Ripatti, P., Ripatti, S., Palotie, A., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.144079 · Cited by 81 · see citing works
Self-citationApolipoprotein B metabolism in homozygous familial hypercholesterolemia.
James, R. W., Martin, B., Pometta, D., Fruchart, J., Duriez, P., Puchois, P., Farriaux, J. P., Tacquet, A., Demant, T., & Clegg, R. J. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38378-4 · Cited by 79 · see citing works
Recent advances in triacylglycerol mobilization by the gut
Xiao, C., Stahel, P., Carreiro, A. L., Buhman, K. K., & Lewis, G. F. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.12.001 · Cited by 77 · see citing works
Stillemark-Billton, P., Borén, J., Andersson, M., Larsson, T. P., Rustaeus, S., Karlsson, K., & Olofsson, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10506 · Cited by 76 · see citing works
Self-citationVergès, B., Duvillard, L., Pais de Barros, J. P., Bouillet, B., Baillot-Rudoni, S., Rouland, A., Sberna, A.-L., Petit, J.-M., Degrace, P., & Demizieux, L. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.310990 · Cited by 75 · see citing works
Cummings, M. H., Watts, G. F., Umpleby, A. M., Hennessy, T. R., Kelly, J. M., Jackson, N. C., & Sönksen, P. H. (1995) · Diabetes · doi:10.2337/diab.44.9.1059 · Cited by 74 · see citing works
Gaw, A. J., Packard, C. J., Lindsay, G. M., Griffin, B. A., CASLAKE, M. J., Lorimer, A. R., & Shepherd, J. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39764-9 · Cited by 73 · see citing works
Self-citationLipid Lowering Drugs: Present Status and Future Developments
Ruscica, M., Ferri, N., Santos, R. D., Sirtori, C. R., & Corsini, A. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00918-3 · Cited by 73 · see citing works
Apolipoprotein B Secretory Regulation by Degradation
Olofsson, S., & Borén, J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.251116 · Cited by 69 · see citing works
Self-citationSpectrum of Mutations and Long-Term Clinical Outcomes in Genetic Chylomicronemia Syndromes
D’Erasmo, L., Costanzo, A. D., Cassandra, F., Minicocci, I., Polito, L., Montali, A., Ceci, F., & Arca, M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313401 · Cited by 69 · see citing works
Wolska, A. T., Lo, L., Sviridov, D. O., Pourmousa, M., Pryor, M., Ghosh, S. S., Kakkar, R. K., Davidson, M., Wilson, S. R., Pastor, R. W., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw7905 · Cited by 69 · see citing works
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
Ruppert, P. M. M., Michielsen, C. C. J. R., Hazebroek, E. J., Pirayesh, A., Olivecrona, G., Afman, L. A., & Kersten, S. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101033 · Cited by 69 · see citing works
Olivecrona, G., & Beisiegel, U. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1545 · Cited by 68 · see citing works
Hiukka, A., Leinonen, E., Jauhiainen, M., Sundvall, J., Ehnholm, C., Keech, A. C., & Taskinen, M. R. (2007) · Diabetologia · doi:10.1007/s00125-007-0751-8 · Cited by 68 · see citing works
Self-citationAdiels, M., Matikainen, N., Westerbacka, J., Söderlund, S., Larsson, T. P., Olofsson, S., Borén, J., & Taskinen, M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.001 · Cited by 68 · see citing works
Self-citationFischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns†, O. T., Yuan, Y., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.001 · Cited by 67 · see citing works
Mattes, R. D. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3656 · Cited by 65 · see citing works
Hansen, S. E. J., Madsen, C. M., Varbo, A., & Nordestgaard, B. G. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz059 · Cited by 64 · see citing works
The pathophysiology of intestinal lipoprotein production
Giammanco, A., Cefalu, A. B., Noto, D., & Averna, M. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00061 · Cited by 61 · see citing works
RNA-targeted therapeutics for lipid disorders
Tsimikas, S. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000549 · Cited by 61 · see citing works
Xiao, C., Pavlic, M., Szeto, L., Patterson, B. W., & Lewis, G. F. (2010) · Diabetes · doi:10.2337/db10-0763 · Cited by 60 · see citing works
Triglycerides and residual risk
Vallejo‐Vaz, A. J., Corral, P., Schreier, L. E., & Ray, K. K. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000530 · Cited by 60 · see citing works
Hansen, S. E. J., Madsen, C. M., Varbo, A., Tybjærg‐Hansen, A., & Nordestgaard, B. G. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.016 · Cited by 59 · see citing works
Sortilin as a Regulator of Lipoprotein Metabolism
Strong, A., & Rader, D. J. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0248-x · Cited by 57 · see citing works
Fielding, B. A., Grady, G. R. M., Humphreys, S. M., Evans, K., & Frayn, K. N. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000763 · Cited by 57 · see citing works
Intracellular events in the assembly of chylomicrons in rabbit enterocytes
Cartwright, I. J., Plonné, D., & Higgins, J. A. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31966-0 · Cited by 57 · see citing works
Jackson, K. G., Wolstencroft, E. J., Bateman, P. A., Yaqoob, P., & Williams, C. M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.25 · Cited by 56 · see citing works
Pieke, B., von Eckardstein, A., Gülbahçe, E., Chirazi, A., Schulte, H., Assmann, G., & Wahrburg, U. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801440 · Cited by 55 · see citing works
Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia
Adiels, M., Taskinen, M., Björnson, E., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Hakkarainen, A., Lundbom, N., Sihlbom, C., et al. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13744 · Cited by 55 · see citing works
Self-citationBjörnson, E., Packard, C. J., Adiels, M., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Sihlbom, C., Thorsell, A., Zhou, H., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12877 · Cited by 54 · see citing works
Self-citationApolipoprotein C-II: the re-emergence of a forgotten factor
Wolska, A. T., Reimund, M., & Remaley, A. T. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000680 · Cited by 54 · see citing works
Casula, M., Olmastroni, E., Gazzotti, M., Galimberti, F., Zambon, A., & Catapano, A. L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105060 · Cited by 54 · see citing works
Blom, D. J., Raal, F. J., Santos, R. D., & Marais, A. D. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0809-3 · Cited by 51 · see citing works
Brief oral stimulation, but especially oral fat exposure, elevates serum triglycerides in humans
Mattes, R. D. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90591.2008 · Cited by 50 · see citing works
Ginsberg, H. N. (1997) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1997.tb03051.x · Cited by 47 · see citing works
Oral Glucose Mobilizes Triglyceride Stores From the Human Intestine
Xiao, C., Stahel, P., Carreiro, A. L., Hung, Y.-H., Dash, S., Bookman, I. D., Buhman, K. K., & Lewis, G. F. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.002 · Cited by 46 · see citing works
Björnson, E., Packard, C. J., Adiels, M., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Hakkarainen, A., Lundbom, N., Lundbom, J., et al. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13017 · Cited by 46 · see citing works
Self-citationAhmed, O., Littmann, K., Gustafsson, U. O., Pramfalk, C., Öörni, K., Larsson, L., Minniti, M. E., Sahlin, S., Camejo, G., Parini, P., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009876 · Cited by 45 · see citing works
Familial Chylomicronemia Syndrome (FCS): Recent Data on Diagnosis and Treatment
Gallo, A., Béliard, S., D’Erasmo, L., & Bruckert, É. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00885-1 · Cited by 44 · see citing works
Dai, W., Zhang, Z., Yao, C., & Zhao, S. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1166-5 · Cited by 43 · see citing works
Liu, H., Talmud, P. J., Lins, L., Brasseur, R., Olivecrona, G., Peelman, F., Vandekerckhove, J. S., Rosseneu, M., & Labeur, C. (2000) · Biochemistry · doi:10.1021/bi0009441 · Cited by 42 · see citing works
Regulation of human apolipoprotein B gene expression at multiple levels
Wang, A., Liu, D., & Liang, C. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00313-6 · Cited by 42 · see citing works
Transport of LDLs into the arterial wall: impact in atherosclerosis
Zhang, X., & Fernandez-Hernando, C. F. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000701 · Cited by 41 · see citing works
Effects of liraglutide on the metabolism of triglyceride-rich lipoproteins in type 2 diabetes
Taskinen, M., Björnson, E., Matikainen, N., Söderlund, S., Pietiläinen, K. H., Ainola, M., Hakkarainen, A., Lundbom, N., Fuchs, J., Thorsell, A., et al. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14328 · Cited by 40 · see citing works
Self-citationRole of the Gut in Diabetic Dyslipidemia
Stahel, P., Xiao, C., Nahmias, A., & Lewis, G. F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00116 · Cited by 39 · see citing works
Insights into incretin-based therapies for treatment of diabetic dyslipidemia
Stemmer, K., Finan, B., DiMarchi, R. D., Tschöp, M. H., & Müller, T. D. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.05.008 · Cited by 39 · see citing works
Genetics of hypertriglyceridemia and atherosclerosis
Gill, P. K., Dron, J. S., & Hegele, R. A. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000839 · Cited by 39 · see citing works
The angiopoietin-like protein 3
Arca, M., Minicocci, I., & Maranghi, M. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283630cf0 · Cited by 37 · see citing works
Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans
Prinsen, B. H. C. M. T., Romijn, J. A., Bisschop, P. H. L. T., de Barse, M. M. J., Barrett, P. H. R., Ackermans, M. T., Berger, R., Rabelink, T. J., & der Velden, M. G. M. D. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300023-jlr200 · Cited by 37 · see citing works
Reeskamp, L. F., Tromp, T. R., & Stroes, E. S. G. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000679 · Cited by 37 · see citing works
Physical State of Lipids and Foreign Substances Producing Atherosclerosis
Moreton, J. R. (1948) · Science · doi:10.1126/science.107.2780.371 · Cited by 36 · see citing works
Chan, D. C., Watts, G. F., Somaratne, R. M., Wasserman, S. M., Scott, R. C., & Barrett, P. H. R. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310882 · Cited by 36 · see citing works
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Björnson, E., Adiels, M., Taskinen, M.-R., Burgess, S., Rawshani, A., Borén, J., & Packard, C. J. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad337 · Cited by 183 · see citing works
Self-citationLi, Z., Zhang, B., Liu, Q., Tao, Z., Ding, L., Guo, B., Zhang, E., Zhang, H., Meng, Z., Guo, S., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104543 · Cited by 137 · see citing works
Zhao, Y., Zhuang, Z., Li, Y., Xiao, W., Song, Z., Huang, N., Wang, W., Dong, X., Jia, J., Clarke, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46686-x · Cited by 117 · see citing works
Xu, H., She, P., Zhao, Z., Ma, B., Li, G., & Wang, Y. (2023) · Advanced Materials · doi:10.1002/adma.202300439 · Cited by 99 · see citing works
Apolipoprotein B-containing lipoproteins in atherogenesis
Borén, J., Packard, C. J., & Binder, C. J. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01111-0 · Cited by 104 · see citing works
Self-citationSheng, G., Kuang, M., Yang, R., Zhong, Y., Zhang, S., & Zou, Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03470-z · Cited by 86 · see citing works
VLDL Biogenesis and Secretion: It Takes a Village
Zwol, W. H.-V., van de Sluis, B., Ginsberg, H. N., & Kuivenhoven, J. A. (2024) · Circulation Research · doi:10.1161/circresaha.123.323284 · Cited by 83 · see citing works
Lipids dysregulation in diseases: core concepts, targets and treatment strategies
Dakal, T. C., Xiao, F., Bhusal, C. K., Sabapathy, P. C., Segal, R., Chen, J., & Bai, X. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-024-02425-1 · Cited by 82 · see citing works
Understanding the cause of type 2 diabetes
Taylor, R. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00157-8 · Cited by 83 · see citing works
Bae, J. H., Lim, H., & Lim, S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.03.014 · Cited by 78 · see citing works
Triglyceride-rich lipoproteins and cardiovascular diseases
Xu, D., Xie, L., Cheng, C., Xue, F., & Sun, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1409653 · Cited by 73 · see citing works
Inflammation and Insulin Resistance in Diabetic Chronic Coronary Syndrome Patients
Li, T., Wang, P., Wang, X., Liu, Z., Zhang, Z., Zhang, Y., Wang, Z., Feng, Y., Wang, Q., Guo, X., et al. (2023) · Nutrients · doi:10.3390/nu15122808 · Cited by 71 · see citing works
Triglyceride-Rich Lipoprotein Metabolism: Key Regulators of Their Flux
Gugliucci, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134399 · Cited by 65 · see citing works
Exploring apolipoprotein C-III: pathophysiological and pharmacological relevance
Packard, C. J., Pirillo, A., Tsimikas, S., Ference, B. A., & Catapano, A. L. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad177 · Cited by 65 · see citing works
Self-citationMetabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study
Wang, Z., Chen, J., Zhu, L., Jiao, S., Chen, Y., & Sun, Y. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03567-3 · Cited by 58 · see citing works
Target Populations for Novel Triglyceride-Lowering Therapies
Nordestgaard, A. T., Tybjærg-Hansen, A., Mansbach, H., Kersten, S., Nordestgaard, B. G., & Rosenson, R. S. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.02.035 · Cited by 54 · see citing works
Yi, M., You, Y., Zhang, Y., Wu, G., Karrar, E. M. A., Zhang, L., Zhang, H., Jin, Q., & Wang, X. (2023) · Molecules · doi:10.3390/molecules28020672 · Cited by 52 · see citing works
Wang, K., Wang, R., Yang, J., Liu, X., Shen, H., Sun, Y., Zhou, Y., Fang, Z. A., & Ge, H. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.913869 · Cited by 49 · see citing works
Li, X., Xie, E., Sun, S., Shen, J., Ding, Y., Wang, J., Peng, X., Zheng, R., Farag, M. A. F., & Xiao, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.014 · Cited by 46 · see citing works
Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease
Ganda, O. P. (2023) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000875 · Cited by 42 · see citing works
The chylomicron saga: time to focus on postprandial metabolism
Gugliucci, A. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1322869 · Cited by 41 · see citing works
HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome
Alcover, S., Ramos-Regalado, L., Girón, G., Muñoz‐García, N., & Vilahur, G. (2025) · Antioxidants · doi:10.3390/antiox14040434 · Cited by 45 · see citing works
Lam, S. M., Wang, Z., Song, J., Shi, Y., Liu, W., Wan, L., Duan, K., Chua, G. H., Zhou, Y., Wang, G., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.009 · Cited by 39 · see citing works
Tessier, A., Wang, F., Liang, L., Wittenbecher, C., Haslam, D. E., Eliassen, A. H., Tobias, D. K., Li, J., Zeleznik, O. A., Ascherio, A., et al. (2024) · Med · doi:10.1016/j.medj.2024.01.010 · Cited by 37 · see citing works
Biosynthesis and Metabolism of ApoB-Containing Lipoproteins
Borén, J., Taskinen, M., & Packard, C. J. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062222-020716 · Cited by 43 · see citing works
Self-citationHan, M., Huang, K., Shen, C., Hu, H., Liu, F., Li, J., Yang, X., Chen, J.-C., Liu, X., Cao, J., et al. (2024) · Stroke · doi:10.1161/strokeaha.124.046811 · Cited by 35 · see citing works
Stimuli-responsive polymer-based nanosystems for cardiovascular disease theranostics
Liu, Y., Li, C., Yang, X. P., Yang, B. T., & Fu, Q. (2024) · Biomaterials Science · doi:10.1039/d4bm00415a · Cited by 30 · see citing works
Chapman, M. J., Packard, C. J., Björnson, E., Ginsberg, H. N., & Borén, J. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120529 · Cited by 32 · see citing works
Self-citationElías-López, D., Doi, T., Nordestgaard, B. G., & Kobylecki, C. J. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000999 · Cited by 29 · see citing works
[Incisional hernia after surgery for abdominal aortic aneurysm].
Augestad, K. M., Wilsgaard, T., & Solberg, S. K. (2002) · PubMed · Cited by 29 · see citing works
Sidorkiewicz, M. (2024) · Nutrients · doi:10.3390/nu16223937 · Cited by 28 · see citing works
Hypercholesterolemia and inflammation—Cooperative cardiovascular risk factors
Gallo, A., Goff, W. L., Santos, R. D., Fichtner, I., Carugo, S., Corsini, A., Sirtori, C. R., & Ruscica, M. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14326 · Cited by 26 · see citing works
Causal cardiovascular risk factors for dementia: insights from observational and genetic studies
Kjeldsen, E. W., & Frikke‐Schmidt, R. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae235 · Cited by 28 · see citing works
Paoli, A. (2025) · Nutrients · doi:10.3390/nu17040663 · Cited by 26 · see citing works
Akivis, Y., Alkaissi, H. R., McFarlane, S. I., & Bukharovich, I. F. (2024) · Current Cardiology Reviews · doi:10.2174/011573403x272750240109052319 · Cited by 29 · see citing works
Remnant Cholesterol and Residual Risk of Atherosclerotic Cardiovascular Disease
Li, X., Li, Z.-F., & Wu, N. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm25985 · Cited by 26 · see citing works
The lipidomic correlates of epigenetic aging across the adult lifespan: A population‐based study
Liu, D., Aziz, N. A., Landstra, E. N., & Breteler, M. M. B. (2023) · Aging Cell · doi:10.1111/acel.13934 · Cited by 23 · see citing works
Tramontano, D., D'Erasmo, L., Larouche, M., Brisson, D., Lauzière, A., Di Costanzo, A., Bini, S., Minicocci, I., Covino, S., Baratta, F., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119146 · Cited by 23 · see citing works
New insights into foam cells in atherosclerosis
Ai, J., Tang, X., Zhou, Y., Mao, B., Zhang, Q., Zhao, J., Chen, W., & Cui, S. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf202 · Cited by 23 · see citing works
The Novel Role of Metabolism-Associated Molecular Patterns in Sepsis
Zhu, X.-X., Zhang, W.-W., Wu, C., Wang, S.-S., Smith, F. G., Jin, S., & Zhang, P. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.915099 · Cited by 23 · see citing works
Taskinen, M., Matikainen, N., Björnson, E., Söderlund, S., Inkeri, J., Hakkarainen, A., Parviainen, H., Sihlbom, C., Thorsell, A., Andersson, L. K., et al. (2023) · Diabetologia · doi:10.1007/s00125-023-06008-0 · Cited by 23 · see citing works
Self-citationLiu, S., Zhang, D., Ju, J., Wang, A., Du, T., Chen, X., Song, Y., Gao, Z., & Xu, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1260764 · Cited by 23 · see citing works
Kumari, A., Larsen, S. W. R., Bondesen, S., Qian, Y., Tian, H., Walker, S. G., Davies, B. S. J., Remaley, A. T., Young, S. G., Konrad, R. J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420721122 · Cited by 20 · see citing works
Li, Z., Yu, C., Zhang, H., Chen, R., Zhao, Y., & Zheng, Z. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02537-z · Cited by 20 · see citing works
Hillesheim, E., Yin, X., Sundaramoorthy, G. P., & Brennan, L. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200620 · Cited by 20 · see citing works
Qian, Q., Wu, J., Wang, C., Yang, Z., Cheng, Y., Zheng, Y., Wang, X., & Wang, H. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.125785 · Cited by 19 · see citing works
Tang, H., Liu, Z., Han, G., Geng, J., Liu, B., Zhang, R., & Zhang, Z. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321255121 · Cited by 19 · see citing works
Impact of Remnant Cholesterol on Cardiovascular Risk in Diabetes
Elías-López, D., Wadström, B. N., Vedel‐Krogh, S., Kobylecki, C. J., & Nordestgaard, B. G. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01555-1 · Cited by 18 · see citing works
Li, H., Ke, X., Feng, B., Tian, H., Cai, Z., Zhang, A., & Man, Q. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1500650 · Cited by 18 · see citing works
Jo, S. (2025) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2025.14.3.247 · Cited by 19 · see citing works
Sugar and Dyslipidemia: A Double-Hit, Perfect Storm
Gugliucci, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175660 · Cited by 18 · see citing works
Sarkar, S. K., Matyas, A., Asikhia, I., Hu, Z., Golder, M., Beehler, K., Kosenko, T., & Lagace, T. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.960272 · Cited by 17 · see citing works
SLC16A7 Promotes Triglyceride Deposition by De Novo Lipogenesis in Chicken Muscle Tissue
Wang, Y., Liu, L., Liu, X., Tan, X., Zhu, Y., Luo, N., Zhao, G., Cui, H., & Wen, J. (2022) · Biology · doi:10.3390/biology11111547 · Cited by 17 · see citing works
Zhu, L., Fang, S., Zhang, Y., Sun, X., Yang, P., Lu, W., & Yu, L. L. (2024) · Nutrients · doi:10.3390/nu16091299 · Cited by 17 · see citing works
Elías-López, D., Kobylecki, C. J., Vedel‐Krogh, S., Doi, T., & Nordestgaard, B. G. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119241 · Cited by 16 · see citing works
Colesterol remanente, riesgo vascular y prevención de la arteriosclerosis
Pintó, X., Fanlo‐Maresma, M., Esteve, V., Millán, J., Blanco, A., Blasco, M., Díaz-Díaz, J. L., Rodríguez, Á. D., Mangas, A., Pascual, V., et al. (2023) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2023.02.001 · Cited by 18 · see citing works
Wen, Y., Li, Y., Liu, T., Huang, L., Yao, L., Deng, D., Luo, W., Cai, W., Zhong, S., Jin, T., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155968 · Cited by 16 · see citing works
Gonçalves, M., Costa, M., Paiva‐Martins, F., & Silva, P. (2024) · Molecules · doi:10.3390/molecules29204841 · Cited by 16 · see citing works
Smith, K., Dennis, K. M. J. H., & Hodson, L. (2025) · Experimental Physiology · doi:10.1113/ep092001 · Cited by 17 · see citing works
How ANGPTL3 Inhibition Will Help Our Clinical Practice?
Bini, S., Tramontano, D., Minicocci, I., Costanzo, A. D., Tambaro, F., D’Erasmo, L., & Arca, M. (2023) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01076-w · Cited by 15 · see citing works
Wen, Y., Chen, Y., & Konrad, R. J. (2023) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000910 · Cited by 15 · see citing works
Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids
Lichtenstein, L., Cheng, C. W., Bajarwan, M., Evans, E. L., Gaunt, H. J., Bartoli, F., Chuntharpursat-Bon, E., Patel, S., Konstantinou, C., Futers, T. S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adq3075 · Cited by 15 · see citing works
Wang, Y., Yu, F., Zheng, X., Li, J., Zhang, Z., Zhang, Q., Chen, J., He, Y., Yang, H., & Zhou, P. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01880-6 · Cited by 14 · see citing works
Wang, Q., Zhang, H., Jin, Q., & Wang, X. (2023) · Foods · doi:10.3390/foods12163005 · Cited by 14 · see citing works
Li, Z., Shi, B., Li, N., Sun, J., Zeng, X., Huang, R., Bok, S., Chen, X., Han, J., Yallowitz, A. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51155-6 · Cited by 14 · see citing works
Li, J., Hou, D., Li, J., Li, R., & Sun, M. Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-96090-8 · Cited by 17 · see citing works
Diversity of extracellular vesicle sources in atherosclerosis: role and therapeutic application
Zhang, Y., Zhang, W., Wu, Z., & Chen, Y. (2025) · Angiogenesis · doi:10.1007/s10456-025-09983-7 · Cited by 14 · see citing works
Li, J., Zhen, H., Yang, S., Yan, Q., & Jiang, Z. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300187 · Cited by 13 · see citing works
Hypertriglyceridemia: molecular and genetic landscapes
Scicchitano, P., Amati, F., Ciccone, M. M., D’Ascenzi, F., Imbalzano, E., Liga, R., Paolillo, S., Pastore, M. C., Rinaldi, A., Mattioli, A. V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126364 · Cited by 13 · see citing works
Zhou, J., & Wang, X. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107387 · Cited by 13 · see citing works
Gómez-Álvarez, N., Boppre, G., Hermosilla-Palma, F. A., Reyes-Amigo, T., de Oliveira, J. J. F., & Fonseca, H. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175221 · Cited by 13 · see citing works
Xu, M., Chen, Z., Li, Y., Li, Y., Ge, G., Dai, R.-Z., Ni, N., Tao, J., Wang, H., Chen, Q., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00288-x · Cited by 13 · see citing works
Li, L., Hu, Y. M., Wang, Y., Wu, X.-X., Lin, S.-T., Li, H., Zhang, J., Fan, G., Wang, Z., Wang, B., et al. (2025) · Foods · doi:10.3390/foods14101707 · Cited by 12 · see citing works
Overexpression of NgBR inhibits high-fat diet–induced atherosclerosis in ApoE-deficiency mice
Gong, K., Wang, M., Wang, D., Gao, Y., Ma, L., Yang, X., Zhu, X., Chen, S., Zhang, M., Li, H., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000048 · Cited by 12 · see citing works
Yang, X., Weber, A. A., Mennillo, E., Secrest, P., Chang, M. W., Wong, S., Le, S., Liu, J., Benner, C. W., Karin, M., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12381 · Cited by 12 · see citing works
The biogenesis and transport of triglyceride-rich lipoproteins
Zhang, L., Wang, X., & Chen, X. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.015 · Cited by 12 · see citing works
Xiao, X., Wu, Y., Jie, Z., Lü, L., Li, Y., Hu, W. H., Li, Y. M., & Zhong, S. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106906 · Cited by 13 · see citing works
Long, H., Huang, R., Zhu, S., Wang, Z., Liu, X., & Zhu, Z. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141663 · Cited by 12 · see citing works
Risti, R., Gunn, K. H., Hiis-Hommuk, K., Seeba, N.-N., Karimi, H., Villo, L., Vendelin, M., Neher, S. B., & Lõokene, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283358 · Cited by 12 · see citing works
Rehman, M. B., Björnson, E., Adiels, M., Morze, J., Bergström, G. M. L., Gummesson, A., Erlinge, D., Fall, T., Matic, L. P., Söderberg, S., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehaf1124 · Cited by 11 · see citing works
Self-citationMitochondrial Homeostasis in Obesity-related Hypertriglyceridemia
Mela, V., Ruiz‐Limón, P., Balongo, M., Rad, H. M., Subiri-Verdugo, A., Gonzalez-Jimenez, A., Soler, R., Ocaña, L., el Azzouzi, H., Tinahones, F. J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac332 · Cited by 11 · see citing works
Gao, H., Li, J., Ma, Q., Zhang, Q., Li, M., & Hu, X. (2024) · Global Heart · doi:10.5334/gh.1331 · Cited by 11 · see citing works
Kang, T., Zhou, Y., Fan, C., Zhang, Y., Yu, Y., & Jiang, J. C. (2024) · The EPMA Journal · doi:10.1007/s13167-024-00373-5 · Cited by 11 · see citing works
Borén, J., Packard, C. J., Nordestgaard, B. G., & Catapano, A. L. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf214 · Cited by 12 · see citing works
Self-citationYu, D., Shen, S., Zhang, J., & Wang, Q. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.06.008 · Cited by 11 · see citing works
Remnant cholesterol, vascular risk, and prevention of atherosclerosis
Pintó, X., Fanlo‐Maresma, M., Esteve-Luque, V., & Millán, J. (2023) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2023.07.005 · Cited by 12 · see citing works
Metabolomic aging clock predicts risk of different cardiovascular diseases in the UK Biobank
You, G., Wang, K., Shen, R., Chen, X., Jiang, J., Sun, Y., Wu, D., Xu, J., Huang, K., & Yao, C. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156467 · Cited by 12 · see citing works
Gugliucci, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175229 · Cited by 10 · see citing works
Lin, C., Xia, M., Dai, Y., Huang, Q., Sun, Z., Zhang, G., Luo, R., Peng, Q., Li, J., Wang, X., et al. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100810 · Cited by 11 · see citing works
Alcala-Diaz, J. F., Larriva, A. P. A.-D., Torres-Peña, J. D., Rodríguez-Cantalejo, F., Rangel-Zúñiga, O. A., Yubero‐Serrano, E. M., Gutierrez-Mariscal, F. M., Cardelo, M. P., Luque, R. M., Ordovás, J. M., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.885256 · Cited by 10 · see citing works
Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits
Park, J. K., Bafna, S., Forrest, I. S., Duffy, Á., Márquez‐Luna, C., Petrazzini, B. O., Vy, H. M. T., Jordan, D. M., Verbanck, M., Narula, J., et al. (2023) · eLife · doi:10.7554/elife.80560 · Cited by 9 · see citing works
Lin, Y., Wang, S., Li, Z., Zhou, Y., Wang, R., Wang, Y., & Chen, Y. (2024) · Advanced Science · doi:10.1002/advs.202403451 · Cited by 8 · see citing works
Yang, N., Wang, M., Liu, J., Liu, J., Hao, Y., Zhao, D., & on behalf of CCC-ACS Investigators (2022) · Metabolites · doi:10.3390/metabo12100898 · Cited by 9 · see citing works
Johansen, M. Ø., Moreno‐Vedia, J., Balling, M., Smith, G. D., & Nordestgaard, B. G. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117316 · Cited by 9 · see citing works
Genetics of remnant cholesterol
Wulff, A. B., & Nordestgaard, B. G. (2025) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000991 · Cited by 8 · see citing works
Han, M., Zhou, J., Wan, Z., Chen, M., Yan, M., Feng, W. S., Wang, G., Zhang, J., Zhang, L., Yan, L., et al. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00982-5 · Cited by 8 · see citing works
Triglyceride-based lipotoxicity in the pathophysiology of chronic diseases
Liu, J., Fan, X., Song, Y., & Zhao, J. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.07.004 · Cited by 8 · see citing works
Zhang, Q., Li, L. X., Ma, Z., He, W., Huang, E., Meng, L., Li, L., Tong, T., Yang, H., Liu, Y., et al. (2025) · Animals · doi:10.3390/ani15162459 · Cited by 8 · see citing works
Non-coding RNAs in lipid metabolism and their roles in atherosclerosis
Sallam, T., Solingen, C. V., & Moore, K. J. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01229-9 · Cited by 8 · see citing works
Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged Women
Park, J., Son, M. K., & Park, H. (2023) · Journal of Korean Medical Science · doi:10.3346/jkms.2023.38.e238 · Cited by 8 · see citing works
- Authors
- Borén, J., Taskinen, M.-R., Björnson, E., & Packard, C. J.
- Affiliations
- University of Gothenburg (SE)
- University of Helsinki (FI)
- University of Glasgow (GB)
- Corresponding author
- Borén, Jan
- Venue
- Nature Reviews Cardiology
- Published
- 2022-03-22
- Volume
- 19
- Issue
- 9
- Pages
- 577-592
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W4220891222
- Semantic Scholar
- 43b00c155f869658a4650440b8527740c6158985
- Cited by
- 315
- References
- 238
- Citations by year
- 2026: 74 · 2025: 99 · 2024: 78 · 2023: 48 · 2022: 14
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- triglyceride-rich lipoproteins, lipoprotein metabolism, hypertriglyceridemia, dyslipidemia, atherogenesis, atherosclerotic cardiovascular disease, triglyceride transport, lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, stable isotope tracers, genetic variation, pancreatitis, lipid-lowering therapy, precision medicine
- MeSH terms
- Animals, Humans, Kinetics, Lipoproteins, Mammals, Triglycerides, Hypertriglyceridemia, Dyslipidemias, Atherosclerosis
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