Collider Bias
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This JAMA Guide to Statistics and Methods describes collider bias, illustrates examples in directed acyclic graphs, and explains how it can threaten the internal validity of a study and the accurate estimation of causal relationships in randomized clinical trials and observational studies.
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The criterion for minimal eligibility in a test negative design is that a patient was tested, so this selection bias could create a scenario where we condition on the collider.
“The criterion for minimal eligibility in a test negative design is the fact that a patient was tested, so this selection bias could create a scenario where we condition on the collider (testing is a common effect of both healthcare seeking behaviour and potentially of the severity of the SARS-CoV-2 manifestation, which prompts the patient to be tested, as seen in fig 3C).41”
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Cites
A structural approach to selection bias
Hernán, M. A., Hernández-Díaz, S., & Robins, J. M. (2004) · Epidemiology · doi:10.1097/01.ede.0000135174.63482.43 · Cited by 2,844 · see citing works
Reducing bias through directed acyclic graphs
Shrier, I., & Platt, R. W. (2008) · BMC Medical Research Methodology · doi:10.1186/1471-2288-8-70 · Cited by 1,394 · see citing works
Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial
Valls-Pedret, C., Sala-Vila, A., Serra-Mir, M., Corella, D., de la Torre, R., Martínez-González, M. Á., Martínez-Lapiscina, E. H., Fitó, M., Pérez-Heras, A., Salas-Salvadó, J., et al. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.1668 · Cited by 952 · see citing works
Collider bias undermines our understanding of COVID-19 disease risk and severity
Griffith, G. J., Morris, T. T., Tudball, M. J., Herbert, A., Mancano, G., Pike, L., Sharp, G. C., Sterne, J., Palmer, T. M., Davey Smith, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19478-2 · Cited by 826 · see citing works
Fosbøl, E. L., Butt, J. H., Østergaard, L., Andersson, C., Selmer, C., Kragholm, K. H., Schou, M., Phelps, M. D., Gislason, G., Gerds, T. A., et al. (2020) · JAMA · doi:10.1001/jama.2020.11301 · Cited by 378 · see citing works
Causal Directed Acyclic Graphs
Lipsky, A. M., & Greenland, S. (2022) · JAMA · doi:10.1001/jama.2022.1816 · Cited by 304 · see citing works
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Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia
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- Authors
- Holmberg, M. J., & Andersen, L. W.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Andersen, Lars W.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2022-04-05
- Volume
- 327
- Issue
- 13
- Pages
- 1282
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4221073740
- Cited by
- 229
- References
- 6
- Citations by year
- 2026: 48 · 2025: 62 · 2024: 53 · 2023: 49 · 2022: 15 · 2020: 1 · 2012: 1
- FWCI
- 33.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Keywords
- collider bias, directed acyclic graphs, internal validity, causal inference, randomized controlled trials, observational studies, confounding, selection bias
- MeSH terms
- Risk Factors, Bias
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