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Biomarker-Guided Development of DNA Repair Inhibitors

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Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies

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DNA damage induces p53-independent apoptosis through ribosome stalling

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Inside the hypoxic tumour: reprogramming of the DDR and radioresistance

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Roles and regulation of tRNA-derived small RNAs in animals

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NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance

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SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell–mediated immunity

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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

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Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

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Mechanistic understanding of human SLFN11

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A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation

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SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

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The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications

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Structural, molecular, and functional insights into Schlafen proteins

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Serum tRNA‐derived fragments (tRFs) as potential candidates for diagnosis of nontriple negative breast cancer

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A wake-up call for cancer DNA damage: the role of Schlafen 11 (SLFN11) across multiple cancers

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Schlafen 11 Restricts Flavivirus Replication

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SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

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Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers

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Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

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Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis

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Mechanisms and biomedical implications of –1 programmed ribosome frameshifting on viral and bacterial mRNAs

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Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy

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Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia

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PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches

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Structural and biochemical characterization of human Schlafen 5

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Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response

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The tRNA regulome in neurodevelopmental and neuropsychiatric disease

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Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death

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Emerging translation strategies during virus–host interaction

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SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer

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Schlafens Can Put Viruses to Sleep

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tsRNA modifications: An emerging layer of biological regulation in disease

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SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells

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Reconsidering the mechanisms of action of PARP inhibitors based on clinical outcomes

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Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR

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tRNA ‐derived RNAs : Biogenesis and roles in translational control

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Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA

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Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

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SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

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Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development

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Schlafens: Emerging Proteins in Cancer Cell Biology

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Mitochondrial tRNA-Derived Fragments and Their Contribution to Gene Expression Regulation

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Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

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Novel therapeutic combinations with PARP inhibitors for small cell lung cancer: A bench-to-bedside review

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SLFN11 is a general target for enhancing the sensitivity of cancer to chemotherapy (DNA-damaging agents)

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Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

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Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer?

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Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

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SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer: Am J Cancer Res. 2020; 10(9): 2832-2850

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Impact of Tumour Hypoxia on Evofosfamide Sensitivity in Head and Neck Squamous Cell Carcinoma Patient-Derived Xenograft Models

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Translational quality control and reprogramming during stress adaptation

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Human Schlafen 11 exploits codon preference discrimination to attenuate viral protein synthesis of prototype foamy virus (PFV)

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The emerging role of Schlafen-11 (SLFN11) in predicting response to anticancer treatments: Focus on small cell lung cancer

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tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators

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Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

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Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to cisplatin

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SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation

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Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication

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Human Schlafen 11 inhibits influenza A virus production

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Phosphorylation-mediated conformational change regulates human SLFN11

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Expression of transgenes enriched in rare codons is enhanced by the MAPK pathway

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DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination

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Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

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Schlafen14 Impairs HIV-1 Expression in a Codon Usage-Dependent Manner

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Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer

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“Transfer” of power: The intersection of DNA virus infection and tRNA biology

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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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SLFN11: a pan-cancer biomarker for DNA-targeted drugs sensitivity and therapeutic strategy guidance

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Men who inject opioids exhibit altered tRNA-Gly-GCC isoforms in semen

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The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response

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The Typical tRNA Co-Expresses Multiple 5′ tRNA Halves Whose Sequences and Abundances Depend on Isodecoder and Isoacceptor and Change with Tissue Type, Cell Type, and Disease

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tRNA‐derived fragments as new players in regulatory processes in yeast

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Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?

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The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway

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Interpreting ribosome dynamics during mRNA translation

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RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress

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XPOT Disruption Suppresses TNBC Growth through Inhibition of Specific tRNA Nuclear Exportation and TTC19 Expression to Induce Cytokinesis Failure

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Research progress of the SLFN family in malignant tumors

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CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage

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SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents

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Bacterial Schlafen proteins mediate phage defence

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Interferon-Stimulated Genes that Target Retrovirus Translation

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A rational targeted therapy for platinum-resistant small-cell lung cancer

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SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress

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Viral codon usage and the virus-host interactions

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Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression

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Reversing regulatory safeguards: Targeting the ATR pathway to overcome PARP inhibitor resistance

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In vivo structure profiling reveals human cytosolic and mitochondrial tRNA structurome and interactome in response to stress

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From predictive biomarker to therapeutic target: the dual role of SLFN11 in chemotherapy sensitivity

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SLFN11, far from being limited to responding to cancer DNA damage

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Uncovering the evolving arms race between host immunity and HIV-1

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Exploiting nanopore sequencing advances for tRNA sequencing of human cancer models

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Progress in investigating the relationship between Schlafen5 genes and malignant tumors

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Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations

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Abstract 2573: DNA damaging drugs stimulate tRNA cleavage through SLFN11 to inhibit protein synthesis and induce cell death

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Human intrinsic immunity factor SLFN11 promotes cell death upon DNA damages through cleavage of distinct type II tRNAs and inhibition of proteins syntheses related to DNA damage responses and repairs

Li, M., Kao, E., Malone, D., Gao, X., Wang, J. Y. J., & David, M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.202.supp.194.20

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents

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The Regulation and Activity of Schlafen11

Malone, D. (2017) · eScholarship (California Digital Library)

Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response

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