Blocking negative effects of senescence in human skin fibroblasts with a plant extract
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Abstract There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant Solidago virgaurea subsp. alpestris , which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. When administered to stress-induced premature senescent fibroblasts, this extract changed their global mRNA expression profile and particularly reduced the expression of various SASP components, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block age-related loss of tissue functionality.
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This is consistent with the reported 20%-60% senescent range of geriatric sun-protected skin fibroblasts.
“consistent with the reported 20%–60% senescent range of geriatric sun-protected skin fibroblasts.40,115”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [40]
The Introduction reports that skin contains between 20% and 60% senescent fibroblasts. It does not specify that this range applies to geriatric, sun-protected skin, so those qualifiers are not supported by this paper's text. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAn extract from the plant Solidago virgaurea alpestris exhibited weak senolytic activity in fibroblasts and keratinocytes isolated from skin biopsies of healthy adult donors.
“Lämmermann and colleagues 60 identified an extract from the plant Solidago virgaurea alpestris, which exhibited weak senolytic activity in fibroblasts and keratinocytes isolated from skin biopsies of healthy adult donors.”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [60]
This plant extract reduced the expression of various SASP components, ameliorating the negative paracrine crosstalk between these cells.
“This plant extract reduced the expression of various SASP components, ameliorating the negative paracrine crosstalk between these cells.60”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [60]
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- Authors
- Lämmermann, I., Terlecki-Zaniewicz, L., Weinmüllner, R., Schosserer, M., Dellago, H., de Matos Branco, A. D., Autheried, D., Sevcnikar, B., Kleissl, L., Berlin, I., Morizot, F., Lejeune, F., Fuzzati, N., Forestier, S., Toribio, A., Tromeur, A., Weinberg, L., Higareda Almaraz, J. C., Scheideler, M., Rietveld, M., El Ghalbzouri, A., Tschachler, E., Gruber, F., & Grillari, J.
- Affiliations
- BOKU University (AT)
- University Hospital Heidelberg (DE)
- Leiden University Medical Center (NL)
- Medical University of Vienna (AT)
- Corresponding author
- Grillari, Johannes
- ORCID
- Venue
- npj Aging and Mechanisms of Disease
- Published
- 2018-04-11
- Volume
- 4
- Issue
- 1
- Pages
- 4-4
- ISSN
- 2056-3973 (ISSN-L)
- PMC
- PMC5895844
- OpenAlex
- W2796888593
- Cited by
- 84
- References
- 54
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 19 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 4 · 2018: 1
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Aging and Mechanisms of Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung
- Austrian Federal Ministry of Economy, Family and Youth
- Austrian Science Fund (I2514, FWF: I2514, W 1224)
- Christian Doppler Forschungsgesellschaft (W1224)
- Universität für Bodenkultur Wien
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, senolytics, senescence-associated secretory phenotype, plant extracts, dermal fibroblasts, stress-induced premature senescence, mRNA expression profiling, tissue aging
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