Cited by 245Telomeres, Telomerase, and SenescenceSkin Protection and AgingGenetics, Aging, and Longevity in Model Organisms

Connective tissue and fibroblast senescence in skin aging

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Wlaschek, Meinhard, Maity, Pallab, Makrantonaki, Evgenia, Scharffetter-Kochanek, Karin·2021·Journal of Investigative Dermatology

Abstract

There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.

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Crossref · 10.1016/j.jid.2020.11.010

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128 of 128 references verified0 citation errors · 0 not checkable

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  • The dermal region is more susceptible to photodamage than the epidermis, resulting in loss of skin resilience.

    “In contrast, the dermal region is more susceptible to photodamage, which results in loss of skin resilience [34].”

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Authors
Wlaschek, M., Maity, P., Makrantonaki, E., & Scharffetter-Kochanek, K.
Affiliations
Universität Ulm (DE)
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2021-04
Volume
141
Issue
4
Pages
985-992
ISSN
0022-202X (ISSN-L)
OpenAlex
W3126843737
Cited by
245
References
128
Citations by year
2026: 29 · 2025: 55 · 2024: 57 · 2023: 49 · 2022: 36 · 2021: 19
FWCI
5.37
Type
journal article
Language
en
Open access
Locations
  • Journal of Investigative Dermatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
skin aging, dermal fibroblasts, fibroblast senescence, senescence-associated secretory phenotype, extracellular vesicles, extracellular matrix, natural killer cells, senescence-associated inflammation, skin homeostasis, connective tissue
MeSH terms
Animals, Cell Communication, Connective Tissue, Extracellular Matrix, Fibroblasts, Humans, Killer Cells, Natural, Skin, Skin Aging, Cellular Senescence, Models, Animal, Mice

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