PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease

Cao, Baihui; Chen, Xiaotong; Li, Yubin; Zhou, Tian; Chen, Nuo; Guo, Yaxin; Zhao, Ming; Guo, Chun; Shi, Yongyu; Wang, Qun; Du, Xuexiang; Zhang, Lining; Li, Yan

doi:10.1038/s41531-024-00760-9

PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease

TFE3 and TFEB, as the master regulators of lysosome biogenesis and autophagy, are well characterized to enhance the synaptic protein α-synuclein degradation in protecting against Parkinson's disease (PD) and their levels are significantly decreased in the brain of PD patients. However, how TFE3 a…