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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
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TFEB phosphorylation on specific residues also occurs in the nuclear compartment and enables TFEB nuclear export.
“TFEB phosphorylation on specific residues also occurs in the nuclear compartment and enables TFEB nuclear export [968-970].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [970]
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“…fi ed as a master trans-activator of lysosomal biogenesis and thus its nuclei-cytoplasmic shuttling, which is largely dependent on its multiple serine phosphorylation modulations by mTORC1, PKC β , ERK2 and GSK3 kinases, has been extensively evidenced to critically controls its activity 5 – 7 .”
BackgroundUSP7 protects TFEB from proteasome-mediated degradation
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Metadata
- Authors
- Martina, J. A., Chen, Y., Gucek, M., & Puertollano, R.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2012-06-23
- Volume
- 8
- Issue
- 6
- Pages
- 903-914
- ISSN
- 1554-8627
- 1554-8635
- Cited by
- 1,333
- References
- 6
- Language
- en
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