Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907

Improved vectors and genome-wide libraries for CRISPR screening

Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Zetsche, B., Gootenberg, J. S., Abudayyeh, O. O., Slaymaker, I. M., Makarova, K. S., Essletzbichler, P., Volz, S. E., Joung, J., van der Oost, J., Regev, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.038 · Cited by 4,761

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042

Easy quantitative assessment of genome editing by sequence trace decomposition

Brinkman, E. K., Chen, T., Amendola, M., & van Steensel, B. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku936 · Cited by 2,390

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

Cho, S. W., Kim, S., Kim, J. M., & Kim, J.-S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2507 · Cited by 1,863

The mGluR theory of fragile X mental retardation

Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580

CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets

Noorani, I., Bradley, A., & Rosa, J. D. L. (2020) · Genome biology · doi:10.1186/s13059-020-02118-9 · Cited by 20

CRISPR genome engineering for retinal diseases

Kantor, A., McClements, M. E., Peddle, C. F., Fry, L. E., Salman, A., Cehajic‐Kapetanovic, J., Xue, K., & MacLaren, R. E. (2021) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2021.01.024 · Cited by 19

Toward the Treatment of Inherited Diseases of the Retina Using CRISPR-Based Gene Editing

Hernández-Juárez, J., Rodríguez‐Uribe, G., & Borooah, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.698521 · Cited by 19

Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice

Qiao, H., Tian, Y., Huo, Y., & Man, H. (2022) · iScience · doi:10.1016/j.isci.2022.104595 · Cited by 19

Non-viral approaches for gene therapy and therapeutic genome editing across the blood–brain barrier

Xie, R., Wang, Y., Burger, J. C., Li, D., Zhu, M., & Gong, S. (2023) · Med-X · doi:10.1007/s44258-023-00004-0 · Cited by 22

Hereditary Ataxias: From Bench to Clinic, Where Do We Stand?

Pilotto, F., Bondio, A. D., & Puccio, H. M. (2024) · Cells · doi:10.3390/cells13040319 · Cited by 25

CRISPR to the Rescue: Advances in Gene Editing for the FMR1 Gene

Yrigollen, C. M., & Davidson, B. L. (2019) · Brain Sciences · doi:10.3390/brainsci9010017 · Cited by 19

Nanoparticle Based Gene Therapy Approach: A Pioneering Rebellion in the Management of Psychiatric Disorders

Rehman, S., Nabi, B., Pottoo, F. H., Baboota, S., & Ali, J. (2020) · Current Gene Therapy · doi:10.2174/1566523220666200607185903 · Cited by 20

Smart arginine-equipped polycationic nanoparticles for p/CRISPR delivery into cells

Moradi, P., Hasanzadeh, A., Radmanesh, F., Rajai‐Daryasarei, S., Hosseini, E. S., Kiani, J., Shahbazi, A., Nourizadeh, H., Eslami, M., Dorgalaleh, A., et al. (2021) · Nanotechnology · doi:10.1088/1361-6528/ac357a · Cited by 18

Preparation of carbon dot as a potential CRISPR/Cas9 plasmid delivery system for lung cancer cells

Mohammadinejad, R., Dehshahri, A., Sasan, H., Behnam, B., Ashrafizadeh, M., Gholami, A. S., Pardakhty, A., & Mandegary, A. (2020) · Minerva Biotecnologica · doi:10.23736/s1120-4826.20.02618-x · Cited by 18

CRISPR/Cas: An intriguing genomic editing tool with prospects in treating neurodegenerative diseases

Rahman, S., Datta, M., Kim, J., & Jan, A. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.014 · Cited by 19

Polyrotaxane-based multi-step transformable materials for the delivery of Cas9 ribonucleoprotein

Taharabaru, T., Kihara, T., Onodera, R., Kogo, T., Higashi, K., Moribe, K., Nakamura, T., Motoyama, K., & Higashi, T. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101488 · Cited by 17

Recent advances in neuroepigenetic editing

Xu, S., & Heller, E. A. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.010 · Cited by 17

Genetically Engineering the Nervous System with CRISPR-Cas

Sandoval, A., Elahi, H., & Ploski, J. E. (2020) · eNeuro · doi:10.1523/eneuro.0419-19.2020 · Cited by 18

Genetic therapies for neurological disorders

FitzPatrick, L., & Bird, A. P. (2021) · Human Genetics · doi:10.1007/s00439-021-02399-5 · Cited by 19

Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach

Sandhu, A., Kumar, A., Rawat, K., Gautam, V., Sharma, A., & Saha, L. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i14.3114 · Cited by 17

Engineering CRISPR-Cas9 RNA–Protein Complexes for Improved Function and Delivery

Rouet, R., de Oñate, L., Li, J., Murthy, N., & Wilson, R. C. (2018) · The CRISPR Journal · doi:10.1089/crispr.2018.0037 · Cited by 16

Emerging Perspectives on Prime Editor Delivery to the Brain

BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024) · Pharmaceuticals · doi:10.3390/ph17060763 · Cited by 16

In vivo production of CAR T cell: Opportunities and challenges

Song, Z., Zhou, Y., Wang, B., Geng, Y., Tang, G., Wang, Y., & Yang, J. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101612 · Cited by 17

Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy

Padmaswari, M. H., Agrawal, S., Jia, M. S., Ivy, A., Maxenberger, D. A., Burcham, L. A., & Nelson, C. E. (2023) · Biophysics Reviews · doi:10.1063/5.0131452 · Cited by 18

Advances in Rolling Circle Amplification (RCA)‐Based DNA‐Functional Materials for Cancer Diagnosis and Therapy

You, X., Wang, J., Guo, X., & Yang, D. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300108 · Cited by 18

Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies

Liu, S., Li, H., Xi, S., Zhang, Y., & Sun, T. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s457393 · Cited by 16

Supramolecular Nanosubstrate‐Mediated Delivery for CRISPR/Cas9 Gene Disruption and Deletion

Ban, Q., Yang, P., Chou, S., Qiao, L., Xia, H., Xue, J., Wang, F., Xu, X., Sun, N., Zhang, R. Y., et al. (2021) · Small · doi:10.1002/smll.202100546 · Cited by 16

Recent advances in biomimetic nanodelivery systems for the treatment of depression

Jiang, P., & Li, J. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101781 · Cited by 17

A critical review of in vitro and in vivo biomedical applications of gold nanoparticles: From toxicology to cancer therapy

Özçiçek, İ. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118410 · Cited by 15

Cognitive Enhancement through Genetic Editing: a New Frontier to Explore (and to Regulate)?

Lavazza, A. (2018) · Journal of Cognitive Enhancement · doi:10.1007/s41465-018-0104-1 · Cited by 14

CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines

Witz, A., Dardare, J., François, A., Husson, M., Rouyer, M., Demange, J., Merlin, J., Gilson, P., & Harlé, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-45964-w · Cited by 17

Insights Into the Emerging Role of Baf53b in Autism Spectrum Disorder

Rowland, M. E., Jajarmi, J. M., Osborne, T. S. M., & Ciernia, A. V. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.805158 · Cited by 16

Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy

Wei, C., Zhang, R., Wei, L.-Y., Pan, P., Zu, H., Liu, Y.-Z., Wang, Y., & Shen, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1078342 · Cited by 14

CRISPR Gene-Editing Models Geared Toward Therapy for Hereditary and Developmental Neurological Disorders

Wong, P. K., Cheah, F., Syafruddin, S. E., Mohtar, M. A., Azmi, N., Ng, P. Y., & Chua, E. W. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.592571 · Cited by 14

Cell and Gene Therapies for Mucopolysaccharidoses: Base Editing and Therapeutic Delivery to the CNS

Christensen, C. L., Ashmead, R. E., & Choy, F. Y. M. (2019) · Diseases · doi:10.3390/diseases7030047 · Cited by 13

The molecular basis of the Fragile X syndrome

Smail, H. O. (2023) · Journal of Experimental and Molecular Biology · doi:10.47743/jemb-2023-80 · Cited by 13

Fenton Reaction-Mediated Endolysosomal Disruption for Efficient Cytosolic Protein Delivery

Zhang, P., Yao, Q., Zhang, X., Yi, X., Xiao, C., & Chen, X. (2025) · ACS Nano · doi:10.1021/acsnano.5c01922 · Cited by 14

Coordination chemistry in CRISPR-Cas-based point of care testing: A review of molecular probe development and applications

Jia, Y., Khan, M., Hu, T., Wang, Z., Song, P., Feng, B., Hu, Q., & Wang, Y. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216081 · Cited by 12

In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges

Cantore, A., Fraldi, A., Meneghini, V., & Gritti, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.774618 · Cited by 15

Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models

Megagiannis, P., Suresh, R., Rouleau, G. A., & Zhou, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114562 · Cited by 12

Postnatal therapeutic approaches in genetic neurodevelopmental disorders

Levy, G., & Barak, B. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293133 · Cited by 11

Improving the use of CRISPR/Cas9 gene editing machinery as a cancer therapeutic tool with the help of nanomedicine

Fatima, H., Singh, D., Muhammad, H., Acharya, S., & Aziz, M. A. (2024) · 3 Biotech · doi:10.1007/s13205-024-04186-1 · Cited by 12

Nanoparticle-mediated delivery of non-viral gene editing technology to the brain

Williams, L., & Larsen, J. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102547 · Cited by 10

Application of CRISPR-Cas systems in neuroscience

Bonnerjee, D., & Bagh, S. (2021) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.12.010 · Cited by 10

CRISPR/Cas9 ribonucleoprotein (RNP) complex enables higher viability of transfected cells in genome editing of acute myeloid cells

Cheng, Q., Xia, J., Wang, K., Zhang, Y., Chen, Y., Zhong, Q., Wang, X., & Wu, Q. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3279 · Cited by 10

Near‐Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR‐Cas9 Ribonucleoprotein for Brain Gene Editing

Simões, S. M. N., Lino, M. M., Barrera, A., Rebelo, C., Tomatis, F., Vilaça, A., Breunig, C., Neuner, A. M., Peça, J., González, R., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202401004 · Cited by 9

CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis

Gu, B., Li, M., Li, D., & Huang, K. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10587-7 · Cited by 13

Gene editing of Duchenne muscular dystrophy using biomineralization-based spCas9 variant nanoparticles

Li, S., Du, M., Deng, J., Deng, G., Li, J., Song, Z., & Han, H. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.10.015 · Cited by 10

Vector enabled CRISPR gene editing – A revolutionary strategy for targeting the diversity of brain pathologies

Forgham, H., Liu, L., Zhu, J., Javed, I., Cai, W., Qiao, R., & Davis, T. P. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215172 · Cited by 9

Nanomaterials for intelligent CRISPR-Cas tools: improving environment sustainability

Bahl, E., Jyoti, A., Singh, A., Siddqui, A., Upadhyay, S. K., Jain, D., Shah, M. P., & Saxena, J. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-32101-x · Cited by 10

Advancement in CRISPR/Cas9 Technology to Better Understand and Treat Neurological Disorders

Datta, A., Sarmah, D., Kaur, H., Chaudhary, A., Vadak, N., Borah, A., Shah, S. V., Wang, X., & Bhattacharya, P. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01242-3 · Cited by 9

Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications

Zheng, Q., Wang, W., Zhou, Y., Mo, J., Chang, X., Zha, Z., & Zha, L. (2023) · Biomaterials Science · doi:10.1039/d3bm00788j · Cited by 10

ReGene: Blockchain backup of genome data and restoration of pre-engineered expressed phenotype

Dambrot, S. M. (2018) · IEEE Annual Ubiquitous Computing, Electronics & Mobile Communication Conference (UEMCON) · doi:10.1109/uemcon.2018.8796768 · Cited by 9

Delivering CRISPR to the HIV-1 reservoirs

Gurrola, T. E., Effah, S. N., Sariyer, I. K., Dampier, W., Nonnemacher, M. R., & Wigdahl, B. L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1393974 · Cited by 11

CdSe Quantum Dot-Based Delivery System for CRISPR-Cas9 Mediated Microglial Gene Modulation

Yeo, H.-G., Won, J., Gwon, L. W., Roh, S., Lee, W.-J., Lim, K. S., Jeon, C., Park, J., Je, A. R., Seo, J., et al. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c04586 · Cited by 8

Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader

Khajanchi, N., Patel, V., Dua, R., Kabra, M., Pattnaik, B. R., & Saha, K. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102640 · Cited by 8

Emerging Lipid-Coated Silica Nanoparticles for Cancer Therapy

Noureddine, A., Butner, J. D., Zhu, W., Naydenkov, P. M., Peláez, M. J., Goel, S., Wang, Z., Brinker, C. J., Vittorio Cristini, C., & Dogra, P. (2021) · Nanotechnology in the life sciences · doi:10.1007/978-3-030-74330-7_12 · Cited by 8

TAxI-peptide targeted Cas12a ribonuclease protein nanoformulations increase genome editing in hippocampal neurons

Sellers, D. L., Lee, K., Murthy, N., & Pun, S. H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.057 · Cited by 8

Evolving Tumor Characteristics and Smart Nanodrugs for Tumor Immunotherapy

Sun, W., Xie, S., Liu, S., Hu, X., & Xing, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s453265 · Cited by 8

Electrokinetic convection-enhanced delivery for infusion into the brain from a hydrogel reservoir

Cruz-Garza, J. G., Bhenderu, L. S. S., Taghlabi, K. M., Frazee, K. P., Guerrero, J. R., Hogan, M., Humes, F., Rostomily, R., Horner, P. J., & Faraji, A. H. (2024) · Communications Biology · doi:10.1038/s42003-024-06404-1 · Cited by 7

Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context

Ruschig, M., & Marschall, A. L. J. (2023) · BioDrugs · doi:10.1007/s40259-023-00580-y · Cited by 9

Advances in CRISPR/Cas9 Technology for in Vivo Translation

Çiçek, Y. A., Luther, D. C., Kretzmann, J. A., & Rotello, V. M. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00811 · Cited by 8

Nanotechnology in Pain Management

Torpey, A. P., Bellow, E., Samojedny, V., Ahluwalia, S., Desai, A., Caldwell, W., & Bergese, S. D. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16111479 · Cited by 7

Therapeutic gene editing is here, can regulations keep up?

Kannan, S., & Najjar, D. (2020) · MIT Science Policy Review · doi:10.38105/spr.czm9c2w8ig · Cited by 7

CRISPR-Based Gene Editing Techniques in Pediatric Neurologic Disorders

Chrzanowski, S. M., & Batra, R. (2022) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2024.01.021 · Cited by 7

CRISPR technology in human diseases

Feng, Q., Li, Q., Zhou, H., Wang, Z., Lin, C., Jiang, Z., Liu, T., & Wang, D. (2024) · MedComm · doi:10.1002/mco2.672 · Cited by 8

Modern Approaches to Mouse Genome Editing Using the CRISPR-Cas Toolbox and Their Applications in Functional Genomics and Translational Research

Monteiro, C. J., Heery, D. M., & Whitchurch, J. B. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-33325-5_2 · Cited by 6

Polymer-Functionalized NIR-Emitting Nanoparticles: Applications in Cancer Theranostics and Treatment of Bacterial Infections

Bardhan, N. M., & Belcher, A. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-32036-2_10 · Cited by 6

CRISPR-Cas mediated targeting of resistance genes for combating ESKAPE pathogen infections: A Review

Khan, M. F., Javed, M., Kaur, J., Badwal, A. K., & Singh, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149180 · Cited by 6

CRISPR/CAS as a Powerful Tool for Human Immunodeficiency Virus Cure: A Review

Komninakis, S. V., Domingues, W., Sanabani, S. S., Folgosi, V. Â., Barbosa, I. N., & Casseb, J. (2024) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2022.0148 · Cited by 6

A Proton‐Activatable DNA‐Based Nanosystem Enables Co‐Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy

Li, F., Song, N., Dong, Y., Li, S., Li, L., Liu, Y., Li, Z., & Yang, D. (2022) · Angewandte Chemie · doi:10.1002/ange.202116569 · Cited by 6

CRISPR-Mediated Base Editing: Promises and Challenges for a Viable Oncotherapy Strategy

Huang, L., Yang, C., Chen, Y., Deng, H., Liao, Z., & Xiao, H. (2023) · Human Gene Therapy · doi:10.1089/hum.2023.045 · Cited by 7

The Use of Peptides in the Treatment of Fragile X Syndrome: Challenges and Opportunities

Romagnoli, A., & Marino, D. D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.754485 · Cited by 9

Gene delivery into cells and tissues

Nelson, C. E., Duvall, C. L., Prokop, A., Gersbach, C. A., & Davidson, J. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00030-7 · Cited by 6

Development of Inorganic and Hybrid Nanosystems for Delivery of CRISPR-Based Gene Editors

Spataru, I. A., Mahoro, F., & Badea, I. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00251 · Cited by 6

CRISPR-Cas technologies: Emerging tools from research to clinical application

Hyeon, H., Hwang, S., Luo, Y., Shin, E., Yeom, J., Kim, H., Ryu, M., & Lee, K. (2025) · The Journal of Microbiology · doi:10.71150/jm.2504012 · Cited by 7

ADVANCEMENT OF CROP PRODUCTIVITY VIA CRISPR-NANOPARTICLE INTERFACE

Afzal, A., Syed, S., Khizar, M., Iqbal, J., Ashraf, S., Altaf, A., Mehmood, B., & Khan, M. R. (2023) · Pakistan Journal of Biotechnology · doi:10.34016/pjbt.2023.20.02.826 · Cited by 5

Non-viral systems for intracellular delivery of genome editing tools

Shaikhutdinov, I. K., Ilyasov, P. V., Витальевна, Г. О., & Limareva, L. V. (2024) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-24-28 · Cited by 5

CRISPR-Cpf1 system and its applications in animal genome editing

Han, Y., Jia, Z., Xu, K., Li, Y., Lu, S., & Guan, L. (2024) · Molecular Genetics and Genomics · doi:10.1007/s00438-024-02166-x · Cited by 5

The Synergy between CRISPR and Chemical Engineering

Lau, C., & Tin, C. (2019) · Current Gene Therapy · doi:10.2174/1566523219666190701100556 · Cited by 5

Molecular micromanagement: DNA nanotechnology establishes spatio-temporal control for precision medicine

Kımna, C., & Lieleg, O. (2020) · Biophysics Reviews · doi:10.1063/5.0033378 · Cited by 5

Nanoconjugate formulations for enhanced drug delivery

Oner, E., Ilhan, M., Gultekin, H. E., & Karpuz, M. (2023) · Advanced and Modern Approaches for Drug Delivery · doi:10.1016/b978-0-323-91668-4.00023-x · Cited by 4

Advances in vehicles for in situ delivery: From classical vectors to biologically inspired structures

Wang, H., Tang, X., Pan, X., Tang, H., Gao, J., & Li, Q. (2026) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2026.02.013 · Cited by 4

Rational Design of Spherical Nucleic Acids: Expanding Horizons for Precision Nucleic Acid Therapy

Li, Y., Liu, S., Yang, J., Guo, S., Ao, Y., Cao, X., Qian, W., Ruan, S., Huang, Y., Weng, Y., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c25947 · Cited by 5

AuNP@DNA nanoflares: Preparation and application in bioanalysis and biomedicine

Yang, L., Wei, H., Qing, Z., & Wu, L. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110524 · Cited by 4

Engineering CRISPR for emerging therapeutic applications

Sun, X., & Liu, Z. (2024) · EngMedicine · doi:10.1016/j.engmed.2024.100035 · Cited by 4

Recent Genome-Editing Approaches toward Post-Implanted Fetuses in Mice

Nakamura, S., Inada, E., Saitoh, I., & Sato, M. (2023) · BioTech · doi:10.3390/biotech12020037 · Cited by 4

Rescued from the fate of neurological disorder

Li, Y., Glass, Z., & Xu, Q. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0267-1 · Cited by 4

Autism Spectrum Disorder in the Genomic Era: A Comprehensive Review of Etiology, Precision Diagnostics, Clinical Outcomes, and Emerging Gene-Editing Therapies

Xiong, N., & Yu, Z. (2026) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s585060 · Cited by 3

The application of CRISPR-Cas9 system in brain diseases

Miao, Y., Li, C., Su, Y., Peng, T., Wang, J., Liu, S., Ma, C., Li, L., & Wang, Y. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2629031 · Cited by 3

Non-viral delivery of genome-editing tools for treatment of genetic disorders

Yang, J., Chen, Y., Chen, X., & Ping, Y. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.02.014 · Cited by 3

Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9

Wu, J., Peng, H., Lu, X., Lai, M., Zhang, H., & Le, X. C. (2020) · Angewandte Chemie · doi:10.1002/ange.202014162 · Cited by 3

Applications of CRISPR/CAS9 Technology in Mice and Livestock Genome Editing: Current Research

Maj, D., & Górka, K. (2024) · Annals of Animal Science · doi:10.2478/aoas-2024-0078 · Cited by 4

Nanoparticles-Mediated CRISPR-Cas9 systems for CAR T-cell immunotherapy as smart cancer biotherapeutics

Mousavi, S. M., Kalashgrani, M. Y., Rahmanian, V., Mirshafiei, M., Omidifar, N., Shokripour, M., Lai, C. W., Thomas, P., Aljabri, M. D., Rahman, M. M., et al. (2025) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2025.06.017 · Cited by 4

Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome

Zhao, X., & Bhattacharyya, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-45493-7_2 · Cited by 3

CRISPR/Cas9 technology in neurological disorders: An update for clinicians

Srivastava, A. K., Swarup, V., Kumar, V., Faruq, M., Singh, H. N., & Singh, I. (2020) · Annals of Movement Disorders · doi:10.4103/aomd.aomd_39_19 · Cited by 4

A Preclinical Pipeline for Translational Precision Medicine—Experiences from a Transdisciplinary Brain Tumor Stem Cell Project

Vargas‐Toscano, A., Janiak, C., Sabel, M., & Kahlert, U. D. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090892 · Cited by 3

Polymer-Mediated Delivery of CRISPR-Cas9 Genome-Editing Therapeutics for CNS Disease

Iqbal, S., Alexander-Bryant, A. A., & Larsen, J. (2022) · Springer eBooks · doi:10.1007/978-3-031-11409-0_6 · Cited by 3

Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups

Nakamura, S., Morohoshi, K., Inada, E., Sato, Y., Watanabe, S., Saitoh, I., & Sato, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015301 · Cited by 3

Current Advancement and Future Prospects: Biomedical Nanoengineering

Singh, S. K., & Sahani, H. (2023) · Current Radiopharmaceuticals · doi:10.2174/0118744710274376231123063135 · Cited by 3

Harnessing Crispr-Cas9 Technology In Dentistry: A Promising Avenue For Precision Oral Health- A Literature Review

Patel, V. B., Vanasi, M., Dhimole, A., Jagnade, R. S., & Sithara., K. (2024) · Journal Of Oral Medicine And Dental Research · doi:10.52793/jomdr.2024.5(1)-55 · Cited by 3

Nanodelivery systems for gene editing drugs

Zhang, Y., & Ping, Y. (2025) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2025-0178 · Cited by 3

Gold rush to gene-editing in the brain

Trenkmann, M. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0038-6 · Cited by 3

Nanoparticles for Neural Applications

Ovejero, J. G., Wang, E., Veintemillas-Verdaguer, S., Morales, M. P., & Sorolla, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-81400-7_7 · Cited by 2

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Horejs, C. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0035-6 · Cited by 1

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Trenkmann, M. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0038-6 · Cited by 3

Gold on the brain

Neff, E. P. (2018) · Lab Animal · doi:10.1038/s41684-018-0118-4

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Li, Y., Glass, Z., & Xu, Q. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0267-1 · Cited by 4

Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Metzger, J. M., Wang, Y., Neuman, S. S., Snow, K. J., Murray, S. A., Lutz, C. M., Bondarenko, V., Felton, J., Gimse, K., Xie, R., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121959 · Cited by 38