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Pooled CRISPR screening with single-cell transcriptome readout.

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The technological landscape and applications of single-cell multi-omics

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Genetic and transcriptional evolution alters cancer cell line drug response

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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

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Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways

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Identification of essential genes for cancer immunotherapy

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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

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Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

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Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling

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Systematic mapping of functional enhancer–promoter connections with CRISPR interference

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

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Thiol-linked alkylation for the metabolic sequencing of RNA

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A rectal cancer organoid platform to study individual responses to chemoradiation

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Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

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Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells

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Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

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Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

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Predicting drug response and synergy using a deep learning model of human cancer cells

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Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway

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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

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Insulin resistance causes inflammation in adipose tissue

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CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

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Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

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A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

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Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

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Massively parallel Cas13 screens reveal principles for guide RNA design

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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

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Mxra8 is a receptor for multiple arthritogenic alphaviruses

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Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

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Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions

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In vivo high-throughput profiling of CRISPR-Cpf1 activity

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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

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Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

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Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

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3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

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Optical Pooled Screens in Human Cells

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Massively parallel assessment of human variants with base editor screens

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Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

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Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

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Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

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SLC19A1 is an importer of the immunotransmitter cGAMP.

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Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning

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An exercise-inducible metabolite that suppresses feeding and obesity

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α-Ketoglutarate links p53 to cell fate during tumour suppression

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A new era in functional genomics screens

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Tight nuclear tethering of cGAS is essential for preventing autoreactivity

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Targeted Delivery of CRISPR/Cas9‐Mediated Cancer Gene Therapy via Liposome‐Templated Hydrogel Nanoparticles

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Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

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Cell-to-cell variation in p53 dynamics leads to fractional killing.

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Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

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Single-cell brain organoid screening identifies developmental defects in autism

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Characterization of Hippo Pathway Components by Gene Inactivation

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Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

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Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

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Small-molecule-induced polymerization triggers degradation of BCL6

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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

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On the design of CRISPR-based single-cell molecular screens

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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

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Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway

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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

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Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk

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TF-PROTACs Enable Targeted Degradation of Transcription Factors

Liu, J., Chen, H., Kaniskan, H. Ü., Xie, L., Chen, X., Jin, J., & Wei, W. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03852 · Cited by 247 · see citing works

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized staphylococcus aureus

Abuaita, B. H., Schultz, T. L., & O’Riordan, M. X. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.10.005 · Cited by 223 · see citing works

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

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Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Dufva, O., Koski, J., Maliniemi, P., Ianevski, A., Klievink, J., Leitner, J., Pölönen, P., Hohtari, H., Saeed, K., Hannunen, T., et al. (2020) · Blood · doi:10.1182/blood.2019002121 · Cited by 224 · see citing works

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

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Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity

Mahadevan, N. R., Knelson, E. H., Wolff, J. O., Vajdi, A., Saigí, M., Campisi, M., Hong, D., Thai, T. C., Piel, B., Han, S., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0913 · Cited by 227 · see citing works

Biological plasticity rescues target activity in CRISPR knock outs

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Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens

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Isolated polycystic liver disease genes define effectors of polycystin-1 function

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Transferrin receptor 1 is a reticulocyte-specific receptor for <i>Plasmodium vivax</i>

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A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation

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Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma

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Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

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Survival of pancreatic cancer cells lacking KRAS function

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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

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HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

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Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

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The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms

Incontro, S., Díaz-Alonso, J., Iafrati, J., Vieira, M., Asensio, C. S., Sohal, V. S., Roche, K. W., Bender, K. J., & Nicoll, R. A. (2018) · Nature Communications · doi:10.1038/s41467-018-04439-7 · Cited by 171 · see citing works

Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

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EWS/FLI confers tumor cell synthetic lethality to CDK12 inhibition in Ewing sarcoma

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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

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