Cited by 222Neuroscience and Neural EngineeringPhotoreceptor and optogenetics researchNanoplatforms for cancer theranostics

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Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window

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Wu, Xiang, Jiang, Yuyan, Rommelfanger, Nicholas J., Yang, Fan, Zhou, Qi, Yin, Rongkang, Liu, Junlang, Cai, Sa, Ren, Wei, Shin, Andrew, Ong, Kyrstyn S., Pu, Kanyi, Hong, Guosong·2022·Nature Biomedical Engineering

DOI 10.1038/s41551-022-00862-wPMC PMC9232843

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Abstract

Neural circuitry is typically modulated via invasive brain implants and tethered optical fibres in restrained animals. Here we show that wide-field illumination in the second near-infrared spectral window (NIR-II) enables implant-and-tether-free deep-brain stimulation in freely behaving mice with stereotactically injected macromolecular photothermal transducers activating neurons ectopically expressing the temperature-sensitive transient receptor potential cation channel subfamily V member 1 (TRPV1). The macromolecular transducers, ~40 nm in size and consisting of a semiconducting polymer core and an amphiphilic polymer shell, have a photothermal conversion efficiency of 71% at 1,064 nm, the wavelength at which light attenuation by brain tissue is minimized (within the 400-1,800 nm spectral window). TRPV1-expressing neurons in the hippocampus, motor cortex and ventral tegmental area of mice can be activated with minimal thermal damage on wide-field NIR-II illumination from a light source placed at distances higher than 50 cm above the animal's head and at an incident power density of 10 mW mm-2. Deep-brain stimulation via wide-field NIR-II illumination may open up opportunities for social behavioural studies in small animals.

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Authors: Wu, X., Jiang, Y., Rommelfanger, N. J., Yang, F., Zhou, Q., Yin, R., Liu, J., Cai, S., Ren, W., Shin, A., Ong, K. S., Pu, K., & Hong, G.
Affiliations: Stanford University (US)
Nanyang Technological University (SG)
Corresponding author: Pu, Kanyi
Hong, Guosong
ORCID: Wu, Xiang
Jiang, Yuyan
Rommelfanger, Nicholas J.
Yang, Fan
Zhou, Qi
Yin, Rongkang
Liu, Junlang
Cai, Sa
Ren, Wei
Shin, Andrew
Ong, Kyrstyn S.
Pu, Kanyi
Hong, Guosong
Venue: Nature Biomedical Engineering
Publisher: Springer Science and Business Media LLC
Published: 2022-03-21
Volume: 6
Issue: 6
Pages: 754-770
ISSN: 2157-846X (ISSN-L)
DOI: 10.1038/s41551-022-00862-w
PMC: PMC9232843
OpenAlex: W4221010482
Cited by: 222
References: 88
Citations by year: 2026: 22 · 2025: 65 · 2024: 71 · 2023: 49 · 2022: 15
FWCI: 22.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
DR-NTU (Nanyang Technological University) (submittedVersion)
Funders: National Institute on Aging (R00AG056636)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: wide-field illumination, TRPV1, semiconducting polymer nanoparticles, freely moving mice, hippocampus, motor cortex, ventral tegmental area, social behavior
MeSH terms: Animals, Brain, Lighting, Polymers, Temperature, Transducers, Mice

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Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window

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