Mechanisms and impact of altered tumour mechanics

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915

The basics of epithelial-mesenchymal transition

Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382

Biomechanics. Mechanical Properties of Living Tissues

Fung, Y. C., & Skalak, R. (1982) · Journal of Applied Mechanics · doi:10.1115/1.3162171 · Cited by 6,040

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979

Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527

Mutational landscape and significance across 12 major cancer types

Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170

The extracellular matrix: A dynamic niche in cancer progression

Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024

Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment

Furuhashi, S., Bustos, M. A., Mizuno, S., Ryu, S., Naeini, Y. B., Bilchik, A. J., & Hoon, D. S. �. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00474-w · Cited by 33

Stress responses in stromal cells and tumor homeostasis

Vitale, I., Manic, G., Galassi, C., & Galluzzi, L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.004 · Cited by 33

3D bioprinting technology to mimic the tumor microenvironment: tumor-on-a-chip concept

Samadian, H., Jafari, S., Sepand, M. R., Alaei, L., Malvajerd, S. S., Jaymand, M., Ghobadinezhad, F., Jahanshahi, F., Hamblin, M. R., Derakhshankhah, H., et al. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100160 · Cited by 33

External power-driven micro/nanorobots: Design, fabrication, and functionalization for tumor diagnosis and therapy

An, M., Feng, Y., Liu, Y., & Yang, H. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101204 · Cited by 33

Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis

Mierke, C. T. (2024) · Biomolecules · doi:10.3390/biom14020184 · Cited by 33

Proteoglycans in mechanobiology of tissues and organs: Normal functions and mechanopathology

Farach‐Carson, M. C., Wu, D., & França, C. M. (2024) · Proteoglycan Research · doi:10.1002/pgr2.21 · Cited by 35

Targeted CRISPR/Cas9 Lipid Nanoparticles Elicits Therapeutic Genome Editing in Head and Neck Cancer

Masarwy, R., Breier, D., Stotsky‐Oterin, L., Ad‐El, N., Qassem, S., Naidu, G. S., Aitha, A., Ezra, A., Goldsmith, M., Hazan‐Halevy, I., et al. (2024) · Advanced Science · doi:10.1002/advs.202411032 · Cited by 36

Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties

Chang, C.-S., Seibel, A. J., Avendano, A., Cortes-Medina, M. G., & Song, J. W. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901399 · Cited by 34

Bioactive Glasses as Carriers of Cancer-Targeted Drugs: Challenges and Opportunities in Bone Cancer Treatment

Borges, R., Pelosine, A. M., de Souza, A. C. S., Machado, J., Justo, G. Z., Gamarra, L. F., & Marchi, J. (2022) · Materials · doi:10.3390/ma15249082 · Cited by 31

Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms

Zhang, C., Shen, Y. C., Huang, M.-Y., Wang, G., Miao, Q., Shi, H., Gao, R., Wang, K., & Luo, M. B. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.09.021 · Cited by 43

Neuropilin: Handyman and Power Broker in the Tumor Microenvironment

Niland, S., & Eble, J. A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35582-1_3 · Cited by 30

Fibroblast Reprogramming in Gastrointestinal Cancer

Melissari, M., Chalkidi, N., Sarris, M. E., & Koliaraki, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00630 · Cited by 30

Platelets, Constant and Cooperative Companions of Sessile and Disseminating Tumor Cells, Crucially Contribute to the Tumor Microenvironment

Obermann, W. M. J., Brockhaus, K., & Eble, J. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.674553 · Cited by 30

Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand

Torrino, S., & Bertero, T. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.01.013 · Cited by 30

Extracellular-matrix mechanics regulate cellular metabolism: A ninja warrior behind mechano-chemo signaling crosstalk

Liao, X., Li, X., & Liu, R. R. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09768-z · Cited by 31

In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go?

Trujillo, S. C., Ferrer, G. G., & Ribelles, J. L. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165747 · Cited by 34

Dynamic links between mechanical forces and metabolism shape the tumor milieu

Bertolio, R., Napoletano, F., & Sal, G. D. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102218 · Cited by 28

Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism

Filipe, E. C., Velayuthar, S., Philp, A. M., Nobis, M., Latham, S. L., Parker, A. L., Murphy, K. J., Wyllie, K., Major, G. S., Contreras, O., et al. (2024) · Advanced Science · doi:10.1002/advs.202307963 · Cited by 26

Fluid flow-induced activation of subcellular AMPK and its interaction with FAK and Src

Guo, Y., Steele, H. E., Li, B., & Na, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108208 · Cited by 28

Transforming growth factor-β blockade modulates tumor mechanical microenvironments for enhanced antitumor efficacy of photodynamic therapy

Chen, J., Li, S., Liu, X., Liu, S., Xiao, C., Zhang, Z., Li, S., Li, Z., & Yang, X. (2021) · Nanoscale · doi:10.1039/d1nr01552d · Cited by 28

Evaluating the Impact of a Biomimetic Mechanical Environment on Cancer Invasion and Matrix Remodeling

Micalet, A., Pape, J., Bakkalci, D., Javanmardi, Y., Hall, C. M., Cheema, U., & Moeendarbary, E. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201749 · Cited by 28

Engineering confining microenvironment for studying cancer metastasis

Jiang, K., Liang, L., & Lim, C. T. (2021) · iScience · doi:10.1016/j.isci.2021.102098 · Cited by 27

Mechanobiology of Colorectal Cancer

Brás, M. M., Sousa, S. R., Carneiro, F., Radmacher, M., & Granja, P. L. (2022) · Cancers · doi:10.3390/cancers14081945 · Cited by 28

Biomimetic Matrix Stiffness Modulates Hepatocellular Carcinoma Malignant Phenotypes and Macrophage Polarization through Multiple Modes of Mechanical Feedbacks

Liu, X.-Q., Chen, X.-T., Liu, Z.-Z., Gu, S.-S., He, L.-J., Wang, K.-P., & Tang, R.-Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00669 · Cited by 26

Characterizing intracellular mechanics via optical tweezers-based microrheology

Vos, B. E., Muenker, T. M., & Betz, T. (2024) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2024.102374 · Cited by 28

Softness‐Aided Mild Hyperthermia Boosts Stiff Nanomedicine by Regulating Tumor Mechanics

Li, Z., Zhu, Y., Zhang, Z., Wang, H., Wang, C., Chen, X., Li, S., Zhang, S., Yang, X., & Li, Z. (2024) · Advanced Science · doi:10.1002/advs.202306730 · Cited by 26

Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review

Fang, L., Liu, Y., Qiu, J., & Wan, W. (2022) · International Journal of Bioprinting · doi:10.18063/ijb.v8i4.603 · Cited by 27

Dynamic and reversible shape response of red blood cells in synthetic liquid crystals

Nayani, K., Evans, A. A., Spagnolie, S. E., & Abbott, N. L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007753117 · Cited by 24

Impact of the Nuclear Envelope on Malignant Transformation, Motility, and Survival of Lung Cancer Cells

Stefanello, S. T., Luchtefeld, I., Liashkovich, I., Pethő, Z., Azzam, I., Bulk, E., Rosso, G., Döhlinger, L., Hesse, B., Oeckinghaus, A., et al. (2021) · Advanced Science · doi:10.1002/advs.202102757 · Cited by 24

Biophysical determinants of cancer organotropism

Azubuike, U. F., & Tanner, K. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.11.002 · Cited by 24

Actin-Targeted Magnetic Nanomotors Mechanically Modulate the Tumor Mechanical Microenvironment for Cancer Treatment

Fan, X. P., Chen, H., Li, Y., Feng, Q., Feng, T., Xu, C., Chen, X., Gao, R., Wang, Y., Guo, X., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c17229 · Cited by 23

Effects of biomechanical forces on the biological behavior of cancer stem cells

Tian, B. R., Lin, W., & Zhang, Y. (2021) · Journal of Cancer · doi:10.7150/jca.60893 · Cited by 24

Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy

Chen, J., Zhang, Z., Li, Y., Zeng, H., Li, Z., Wang, C., Chen, X., Deng, Q., Wang, Q., Yang, X., et al. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01812h · Cited by 23

Direct comparison of five different 3D extracellular matrix model systems for characterization of cancer cell migration

Shinsato, Y., Doyle, A. D., Li, W., & Yamada, K. M. (2020) · Cancer Reports · doi:10.1002/cnr2.1257 · Cited by 23

Micropipette-assisted atomic force microscopy for single-cell 3D manipulations and nanomechanical measurements

Feng, Y., & Li, M. (2023) · Nanoscale · doi:10.1039/d3nr02404k · Cited by 22

AREG Upregulation in Cancer Cells via Direct Interaction with Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression Through EGFR-Erk/p38 MAPK Signaling

Nakanishi, T., Koma, Y., Miyako, S., Torigoe, R., Yokoo, H., Omori, M., Yamanaka, K., Ishihara, N., Tsukamoto, S., Kodama, T., et al. (2024) · Cells · doi:10.3390/cells13201733 · Cited by 22

Reversible Control of Gelatin Hydrogel Stiffness by Using DNA Crosslinkers**

Buchberger, A., Saini, H., Eliato, K. R., Zare, A., Merkley, R., Xu, Y., Bernal‐Chanchavac, J., Ros, R., Nikkhah, M., & Stephanopoulos, N. (2021) · ChemBioChem · doi:10.1002/cbic.202100030 · Cited by 22

The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis

Jia, Y., Wang, Y., Niu, L., Zhang, H., Tian, J., Gao, D., Zhang, X., Lu, T. J., Qian, J. W., Huang, G., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001856 · Cited by 21

Constructing 3D In Vitro Models of Heterocellular Solid Tumors and Stromal Tissues Using Extrusion-Based Bioprinting

Flores-Torres, S., Jiang, T., Kort-Mascort, J., Yang, Y. K., Peza-Chavez, O., Pal, S., Mainolfi, A., Pardo, L. A., Ferri, L. E., Bertos, N., et al. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00998 · Cited by 25

Deep Learning Image Recognition-Assisted Atomic Force Microscopy for Single-Cell Efficient Mechanics in Co-culture Environments

Yang, X., Yang, Y., Zhang, Z., & Li, M. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c03046 · Cited by 21

High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas

Luo, C., Shi, Y., Liu, Y., Liu, Q., Mao, M., Luo, M., Yang, K., Wang, W., Chen, C., Niu, Q., et al. (2022) · Laboratory Investigation · doi:10.1038/s41374-022-00825-4 · Cited by 21

Interplay of Fluid Mechanics and Matrix Stiffness in Tuning the Mechanical Behaviors of Single Cells Probed by Atomic Force Microscopy

Wei, J., & Li, M. (2023) · Langmuir · doi:10.1021/acs.langmuir.2c03137 · Cited by 20

The mechanobiology of NK cells- ‘Forcing NK to Sense’ target cells

Wong, D. C. P., & Ding, J. L. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188860 · Cited by 20

Engineering Heterogeneous Tumor Models for Biomedical Applications

Wu, Z., Huang, D., Wang, J., Zhao, Y., Sun, W., & Shen, X. (2023) · Advanced Science · doi:10.1002/advs.202304160 · Cited by 19

Patient-specific colorectal-cancer-associated fibroblasts modulate tumor microenvironment mechanics

Micalet, A., Upadhyay, A., Javanmardi, Y., de Brito, C. G., Moeendarbary, E., & Cheema, U. (2024) · iScience · doi:10.1016/j.isci.2024.110060 · Cited by 21

Unlocking the potential of the tumor microenvironment for cancer therapy

Tufail, M. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154846 · Cited by 20

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

Shi, H., Tian, H., Zhu, T., Liao, Q., Liu, C. X., Yuan, P., Li, Y., Yang, J., Zong, C., Jia, S., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00683-y · Cited by 22

From Helicobacter pylori infection to gastric cancer: Current evidence on the immune response

Gonçalves, V. L. D. S., Santos, M. L. C., Luz, M. S., Marques, H. S., de Brito, B. B., da Silva, F. A. F., Souza, C. L., Oliveira, M. V., & de Melo, F. F. (2022) · World Journal of Clinical Oncology · doi:10.5306/wjco.v13.i3.186 · Cited by 19

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Li, W., Wu, Y., Zhang, Y., Gao, W., Li, X., Luo, H., Lu, M., Liu, Z., & Luo, A. (2025) · Advanced Science · doi:10.1002/advs.202416523 · Cited by 22

Mechanical load inhibits cancer growth in mouse and human hearts

Ciucci, G., Lorizio, D., Bartoloni, N., Budini, M., Colliva, A., Vodret, S., Nguyen, A.-V., Ciacci, L., Texler, B., Cardini, B., et al. (2026) · Science · doi:10.1126/science.ads9412 · Cited by 18

Magnetic microboats for floating, stiffness tunable, air–liquid interface epithelial cultures

Chandrasekaran, A., Kouthouridis, S., Lee, W., Lin, N., Ma, Z., Turner, M. J., Hanrahan, J. W., & Moraes, C. (2019) · Lab on a Chip · doi:10.1039/c9lc00267g · Cited by 19

Mechanical characterization of single cells based on microfluidic techniques

Huang, J., Lin, F., & Xiong, C. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.07.015 · Cited by 18

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Pocaterra, A., Scattolin, G., Romani, P., Ament, C. E., Ribback, S., Chen, X., Evert, M., Calvisi, D. F., & Dupont, S. (2021) · Communications Biology · doi:10.1038/s42003-021-02286-9 · Cited by 19

UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling

Adhikari, S., Singh, V., Nandi, S., Ghosal, M., Raj, N. S., Khanna, J., Bhattacharya, A., Kabiraj, A., Mondal, A., Vasudevan, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114394 · Cited by 17

Links between autophagy and tissue mechanics

Claude‐Taupin, A., Codogno, P., & Dupont, N. (2021) · Journal of Cell Science · doi:10.1242/jcs.258589 · Cited by 17

Softening the tumor matrix through cholesterol depletion breaks the physical barrier for enhanced antitumor therapy

Peng, Z., Yi, Y., Nie, Y., Wang, T., Tang, J., Hong, S., Liu, Y., Huang, W., Sun, S., Tan, H. F., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.027 · Cited by 17

Element-doped ferrite nanoparticles: From magnetic property tuning to biomedical applications

Kang, N., Li, Z., & Zhang, Q. Y. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217151 · Cited by 16

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

Kato, T., Jenkins, R. P., Derzsi, S., Tozluoǧlu, M., Rullan, A., Hooper, S., Chaleil, R. A. G., Fu, X., Joyce, H., Thavaraj, S., et al. (2023) · eLife · doi:10.7554/elife.76520 · Cited by 16

Applications of atomic force microscopy in immunology

Li, J., Liu, Y., Yuan, Y., & Huang, B. (2020) · Frontiers of Medicine · doi:10.1007/s11684-020-0769-6 · Cited by 17

Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer

Fu, X., Zhang, Y., Luo, Q., Ju, Y., & Song, G. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0229 · Cited by 14

Harnessing atomic force microscopy‐based single‐cell analysis to advance physical oncology

Li, M. (2023) · Microscopy Research and Technique · doi:10.1002/jemt.24467 · Cited by 16

Mechanics of actin filaments in cancer onset and progress

Tafazzoli‐Shadpour, M., Mohammadi, E., & Torkashvand, E. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.05.002 · Cited by 14

The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells

Liu, T., Liang, H., Li, Y., Liao, W., Deng, J., Zhang, L., & Shen, F. (2025) · Discover Oncology · doi:10.1007/s12672-025-02456-9 · Cited by 17

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

Zhang, T., Li, Y., Cheng, B., Zhao, X., Liu, M., Feng, J., Bai, Y., Yu, Y., Jiang, P., Geng, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202501335 · Cited by 18

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

Zhou, F., Ju, R. J., Kang, C., Li, J., Yang, A., Libert, A., Sun, Y., Liang, L., Ai, Y., Hu, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66353-z · Cited by 17

Spontaneous formation and spatial self-organization of mechanically induced mesenchymal-like cells within geometrically confined cancer cell monolayers

Lin, F., Zhou, Y., Duan, X., Xu, F., Zhang, Q., Zhang, Y., Wang, P., & Huang, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121337 · Cited by 14

Combining atomic force microscopy with complementary techniques for multidimensional single‐cell analysis

Li, M. (2023) · Journal of Microscopy · doi:10.1111/jmi.13183 · Cited by 16

Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells

Santi, M. D., Zhang, M., Salvo, E., Asam, K. R., Viet, C. T., Xie, T., Amit, M., Aouizerat, B. E., & Ye, Y. (2022) · Advanced Biology · doi:10.1002/adbi.202200187 · Cited by 13

USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop

Mo, H., Li, R., Yang, N., Han, J., Xiao, X., Zhang, Y., Xiao, Z., Jiao, L., Xu, Q., & Tu, K. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216832 · Cited by 15

Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling

Peura, A., Turpin, R., Liu, R., Heilala, M., Salmela, M., Aung, J., Mikkonen, P., Mutka, M., Kovanen, P. E., Niinikoski, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60092-x · Cited by 14

Forces exerted and transduced by cancer‐associated fibroblasts during cancer progression

Bates, M. E., Libring, S., & Reinhart‐King, C. A. (2023) · Biology of the Cell · doi:10.1111/boc.202200104 · Cited by 11

Tenascin C in pancreatic cancer-associated fibroblasts enhances epithelial mesenchymal transition and is associated with resistance to immune checkpoint inhibitor.

Furuhashi, S., Morita, Y., Matsumoto, A., Ida, S., Muraki, R., Kitajima, R., Takeda, M., Kikuchi, H., Hiramatsu, Y., & Takeuchi, H. (2023) · PubMed Central · Cited by 12

Development and applications of lipid hydrophilic headgroups for nucleic acid therapy

Ma, W., Fu, X., Zhao, T., Qi, Y., Zhang, S., & Zhao, Y. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108395 · Cited by 12

The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy

Zhang, P., Li, P., Tang, M., Gimple, R. C., Huang, L., Yue, J., Shen, Q., Du, Y., Zhang, Q., Yang, Z., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2622-1 · Cited by 12

Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death

Dziengelewski, C., Rodrigue, M., Caillier, A., Jacquet, K., Boulanger, M., Bergeman, J., Fuchs, M., Lambert, H., Laprise, P., Richard, D. E., et al. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201805122 · Cited by 14

High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth

Chiang, C.-T., Lau, R., Ghaffarizadeh, A., Brovold, M., Vyas, D., Juarez, E. F., Atala, A., Agus, D. B., Söker, S., Macklin, P., et al. (2021) · GigaScience · doi:10.1093/gigascience/giab026 · Cited by 11

The evolution of spindles and their mechanical implications for cancer metastasis

Chen, Y., Nam, S., Chaudhuri, O., & Huang, H. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1632137 · Cited by 12

Stiffness on shear wave elastography as a potential microenvironment biomarker for predicting tumor recurrence in HBV-related hepatocellular carcinoma

Zhong, X., Long, H., Chen, L., Xie, Y., Shi, Y., Peng, J., Zheng, R., Su, L., Duan, Y., Xie, X., et al. (2023) · Insights into Imaging · doi:10.1186/s13244-023-01505-7 · Cited by 11

Organelle adaptations in response to mechanical forces during tumour dissemination

Graziani, V., Crosas‐Molist, E., George, S. L., & Sanz‐Moreno, V. (2024) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2024.102345 · Cited by 11

The prognostic effect of mechanical, ultrastructural, and ECM signatures in glioblastoma core and rim

Mahaffey, B., Fowler, Z., Lung, Z., Dang, V., Lee, H., Johnson, A. M., Munoz, M. A., Goodin, D. A., Frieboes, H. B., Williams, B., et al. (2024) · APL Bioengineering · doi:10.1063/5.0203570 · Cited by 11

Mechanical regulation of extracellular vesicle activity during tumour progression

Parihar, K., Liu, D.-A., Hassan, G., Issadore, D., Janmey, P. A., Weaver, V. M., Guo, W., & Radhakrishnan, R. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01446-0 · Cited by 13

Substrate Resistance to Traction Forces Controls Fibroblast Polarization

Missirlis, D., Haraszti, T., Heckmann, L., & Spatz, J. P. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.10.043 · Cited by 11

An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells

Wang, H., Boardman, J., Zhang, X., Sun, C., Cai, M., Wei, J., Dong, Z., Feng, M., Liang, D., Hu, S., et al. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341120 · Cited by 11

Long non-coding RNAs CCAT1 and CCAT2 in colorectal liver metastases are tumor-suppressive via MYC interaction and might predict patient outcomes

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