Cited by 337Cellular Mechanics and InteractionsCancer Cells and MetastasisMathematical Biology Tumor Growth

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Mechanisms and impact of altered tumour mechanics

Mohammadi, Hamid, Sahai, Erik·2018·Nature Cell Biology

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Abstract

The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increased cellularity, and the build-up of both solid and interstitial pressure. Increased stiffness then feeds back to increase tumour invasiveness and reduce therapy efficacy. Increased understanding of this interplay is offering new therapeutic avenues.

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Authors: Mohammadi, H., & Sahai, E.
Affiliations: The Francis Crick Institute (GB)
Corresponding author: Sahai, Erik
ORCID: Mohammadi, Hamid
Sahai, Erik
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2018-06-27
Volume: 20
Issue: 7
Pages: 766-774
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/s41556-018-0131-2
OpenAlex: W2809059040
Cited by: 336
References: 145
Citations by year: 2026: 25 · 2025: 52 · 2024: 41 · 2023: 63 · 2022: 44 · 2021: 54 · 2020: 36 · 2019: 18 · 2018: 2
FWCI: 3.09
Type: journal article
Language: en
Update notices: correction (2018-07-10)
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Francis Crick Institute (10144)
Cancer Research UK
Canadian Institutes of Health Research
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
Keywords: tumor stiffness, extracellular matrix, matrix remodeling, stromal fibroblasts, interstitial fluid pressure, solid pressure, tumour invasiveness, carcinogenesis, mechanotherapy
MeSH terms: Animals, Antineoplastic Agents, Cell Communication, Elasticity, Extracellular Matrix, Humans, Neoplasms, Phenotype, Pressure, Stress, Mechanical, Stromal Cells, Mechanotransduction, Cellular, Tumor Microenvironment

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