The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Integrin activation by talin, kindlin and mechanical forces
Open accessAbstract
Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework. In this Perspective, Fässler and co-authors describe current models of how integrin adhesion molecules are activated and stabilised, and the importance of forces in this process.
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Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 503
Pakshir, P., Noskovicova, N., Lodyga, M., Son, D. O., Schuster, R., Goodwin, A., Karvonen, H., & Hinz, B. (2020) · Journal of Cell Science · doi:10.1242/jcs.227900 · Cited by 293
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Metadata
- Authors
- Sun, Z., Costell, M., & Fässler, R.
- Venue
- Nature Cell Biology
- Published
- 2019-01
- Volume
- 21
- Issue
- 1
- Pages
- 25-31
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2901606464
- Cited by
- 543
- References
- 89
- FWCI
- 33.04
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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