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Cited by 543

The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.

Integrin activation by talin, kindlin and mechanical forces

Open access
Sun, Zhiqi, Costell, Mercedes, Fässler, Reinhard·2019·Nature Cell Biology

Abstract

Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework. In this Perspective, Fässler and co-authors describe current models of how integrin adhesion molecules are activated and stabilised, and the importance of forces in this process.

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Crossref · 10.1038/s41556-018-0234-9

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Metadata

Authors
Sun, Z., Costell, M., & Fässler, R.
Venue
Nature Cell Biology
Published
2019-01
Volume
21
Issue
1
Pages
25-31
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2901606464
Cited by
543
References
89
FWCI
33.04
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Integrin activation by talin, kindlin and mechanical forces. https://app.cochat.ai/papers/10.1038/s41556-018-0234-9
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Sun, Z., Costell, M., & Fässler, R. (2019). Integrin activation by talin, kindlin and mechanical forces. Nature Cell Biology. https://doi.org/10.1038/s41556-018-0234-9

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.