The myofibroblast at a glance
Open accessAbstract
In 1971, Gabbiani and co-workers discovered and characterized the “modification of fibroblasts into cells which are capable of an active spasm” (contraction) in rat wound granulation tissue and, accordingly, named these cells ‘myofibroblasts’. Now, myofibroblasts are not only recognized for their physiological role in tissue repair but also as cells that are key in promoting the development of fibrosis in all organs. In this Cell Science at a Glance and the accompanying poster, we provide an overview of the current understanding of central aspects of myofibroblast biology, such as their definition, activation from different precursors, the involved signaling pathways and most widely used models to study their function. Myofibroblasts will be placed into context with their extracellular matrix and with other cell types communicating in the fibrotic environment. Furthermore, the challenges and strategies to target myofibroblasts in anti-fibrotic therapies are summarized to emphasize their crucial role in disease progression.
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Myofibroblasts are main effector cells in fibrogenesis by producing excessive amounts of collagen and generating high contractile forces by incorporating α-SMA into stress fibers.
“Myofibroblasts are main effector cells in fibrogenesis by producing excessive amounts of collagen and generating high contractile forces by incorporating α-smooth muscle actin (α-SMA) into stress fibers (16).”
From Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy (2024) · cites this paper as [16]
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The Molecular Signature of Human Testicular Peritubular Cells Revealed by Single-Cell Analysis
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Multifunctional silk vinyl sulfone-based hydrogel scaffolds for dynamic material-cell interactions
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Fibroblast‐Derived TGFβ1 Regulates Skin Repair and Fibrosis
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Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype
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- Authors
- Pakshir, P., Noskovicova, N., Lodyga, M., Son, D. O., Schuster, R., Goodwin, A., Karvonen, H., & Hinz, B.
- Affiliations
- University of Toronto (CA)
- University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada
- University of Nottingham (GB)
- ORCID
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2020-07-01
- Volume
- 133
- Issue
- 13
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W3042005681
- Cited by
- 293
- References
- 196
- Citations by year
- 2026: 38 · 2025: 49 · 2024: 48 · 2023: 56 · 2022: 59 · 2021: 38 · 2020: 5
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute for Health and Care Research (NIHR-INF-0248, ACF-2014-12-002)
- Mitacs (IT13623, IT13587)
- Canadian Institutes of Health Research (375597)
- Medical Research Council (MR/P001327/1)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- myofibroblasts, fibrosis, wound healing, granulation tissue, myofibroblast activation, precursor cells, signaling pathways, extracellular matrix, antifibrotic therapy, tissue repair
- MeSH terms
- Animals, Cell Differentiation, Extracellular Matrix, Fibroblasts, Fibrosis, Wound Healing, Rats, Myofibroblasts
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