The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells
Open accessAbstract
Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β cell maturation. In particular, we have focused on recapitulating endocrine cell clustering by isolating and reaggregating immature β-like cells to form islet-sized enriched β-clusters (eBCs). eBCs display physiological properties analogous to primary human β cells, including robust dynamic insulin secretion, increased calcium signalling in response to secretagogues, and improved mitochondrial energization. Notably, endocrine cell clustering induces metabolic maturation by driving mitochondrial oxidative respiration, a process central to stimulus-secretion coupling in mature β cells. eBCs display glucose-stimulated insulin secretion as early as three days after transplantation in mice. In summary, replicating aspects of endocrine cell clustering permits the generation of stem-cell-derived β cells that resemble their endogenous counterparts.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In parallel, a large body of work has focused on developing the ideal cellular niche and encapsulation strategies to support normal patterns of hormone secretion while also protecting these cellular implants from autoimmune destruction139,140.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [140]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Transplantation of SC-islets into mice improves their insulin secretion and glucose responsiveness, suggesting that SC-islet immaturity can be resolved.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [44]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“SC-islets generated in vitro remain transcriptionally and functionally immature compared to adult human islets.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [44]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A similar process was used by Nair and colleagues using mechanical agitation to keep human cells suspended in culture, resulting in functional beta-like clusters221.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [221]
The cited source says what the claim attributes to it.
In the citing paper
“These cells have been shown to improve glycemic control in diabetic mice, highlighting their potential utility in vivo.36,37,39–44”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [44]
The cited source says what the claim attributes to it.
In the citing paper
“To this end, significant progress has been made at improving the function of SC-islets when compared to the original protocols,39,40,44,48,49”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 12,145
Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
Mitochondrial Cristae: Where Beauty Meets Functionality
Cogliati, S., Enriquez, J. A., & Scorrano, L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.01.001 · Cited by 816
Sosa‐Pineda, B., Chowdhury, K., Torres, M., Oliver, G. C., & Gruß, P. (1997) · Nature · doi:10.1038/386399a0 · Cited by 804
Improvement in outcomes of clinical islet transplantation: 1999–2010
Barton, F. B., Rickels, M. R., Alejandro, R., Hering, B. J., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J. S., Garfinkel, M. R., Levy, M., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0063 · Cited by 725
Self-citationControlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, T., Puri, S., Haataja, L., Cirulli, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591058 · Cited by 591
Self-citationNkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells
Taylor, B. L., Liu, F., & Sander, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.010 · Cited by 360
Blum, B., Hrvatin, S., Schuetz, C., Bonal, C., Rezania, A., & Melton, D. (2012) · Nature Biotechnology · doi:10.1038/nbt.2141 · Cited by 349
Cited by
Sorted by citations
Items 201–300 of 468
Heaton, E. S., Hu, M., Liu, T., Hui, H., Tan, Y., Ye, K., & Jin, S. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231185858 · Cited by 16
Ghosh, A., Sanyal, A., & Mallick, A. (2023) · Exploration of Medicine · doi:10.37349/emed.2023.00184 · Cited by 16
Verhoeff, K., Cuesta-Gomez, N., Maghera, J., Dadheech, N., Pawlick, R., Smith, N., O’Gorman, D., Razavy, H., Marfil-Garza, B., Young, L. G., et al. (2025) · Transplantation · doi:10.1097/tp.0000000000005108 · Cited by 16
Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
Shcheglova, E. G., Błaszczyk, K., & Borowiak, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734597 · Cited by 18
Microwell bag culture for large-scale production of homogeneous islet-like clusters
Suenaga, R., Konagaya, S., Yamaura, J., Ito, R., Tanaka, S., Ishizaki, Y., & Toyoda, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-09124-w · Cited by 16
Dumasia, N. P., Khanna, A. P., & Pethe, P. S. (2021) · Genes to Cells · doi:10.1111/gtc.12839 · Cited by 16
New advances in insulin products
Rajpoot, K., Tekade, M., Sharma, M. C., Molugulu, N., & Tekade, R. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814455-8.00014-1 · Cited by 15
Emerging molecular technologies for light-mediated modulation of pancreatic beta-cell function
Chen, Z., Truskinovsky, L. F., & Tzanakakis, E. S. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101552 · Cited by 15
Mu-u-min, R., Diané, A., Allouch, A., & Al-Siddiqi, H. (2023) · Biomedicines · doi:10.3390/biomedicines11061577 · Cited by 17
Séraudie, I., Pillet, C., Cesana, B., Bazelle, P., Jeanneret, F., Evrard, B., Chalmel, F., Bouzit, A., Battail, C., Long, J., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06133-z · Cited by 18
Shaheen, R., Gurlin, R. E., Gologorsky, R. C., Blaha, C., Munnangi, P., Santandreu, A., Torres, A., Carnese, P., Nair, G. G., Szot, G. L., et al. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37236 · Cited by 15
Self-citationSARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis
Szlachcic, W. J., Dąbrowska, A., Milewska, A., Ziojla, N., Błaszczyk, K., Barreto-Durán, E., Sanak, M., Surmiak, M., Owczarek, K., Grzanka, D., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104594 · Cited by 16
Shilleh, A. H., & Russ, H. A. (2023) · Cells · doi:10.3390/cells12050698 · Cited by 16
Self-citationDifferent Cells of the Human Body
Mostafa, H. K. K. (2021) · Journal of Microscopy and Ultrastructure · doi:10.4103/jmau.jmau_74_20 · Cited by 14
Recent progress in modeling and treating diabetes using stem cell-derived islets
Maestas, M. M., Bui, M. H., & Millman, J. R. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae059 · Cited by 14
Shi, X., Zhang, K., Yu, F., Qi, Q., Cai, X., & Yu, Z. (2024) · Stem Cells International · doi:10.1155/2024/4073485 · Cited by 14
Sundheim, B., Hirani, K., Blaschke, M., Lemos, J. R. N., & Mittal, R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020383 · Cited by 15
Pancreatic endocrine cell arrangement during human ontogeny
Proshchina, A. E., Krivova, Y. S., Barabanov, V. M., & Saveliev, S. V. (2019) · Acta Histochemica · doi:10.1016/j.acthis.2019.05.010 · Cited by 14
Todorova, D., Zhang, Y., Chen, Q., Liu, J., He, J., Fu, X., & Xu, Y. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103120 · Cited by 14
Self-citationRecent progress in pancreatic islet cell therapy
Sim, E. Z., Shiraki, N., & Kume, S. (2021) · Inflammation and Regeneration · doi:10.1186/s41232-020-00152-5 · Cited by 15
Ghezelayagh, Z., Zabihi, M., Zarkesh, I., Gonçalves, C. A., Larsen, M., Haghparast, N., Pakzad, M., Vosough, M., Arjmand, B., Baharvand, H., et al. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10266-z · Cited by 15
Kimura, A., Toyoda, T., Iwasaki, M., Hirama, R., & Osafune, K. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.08.018 · Cited by 14
Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy
Shang, K., Suzuki, T., Kato, H., Toyoda, T., Tai, Y., & Komatsu, H. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00984.2024 · Cited by 14
Sali, S., Azzam, L., Jaro, T., Ali, A. A. G., Mardini, A., Al-Dajani, O., Khattak, S., Butler, A. E., Azeez, J. M., & Nandakumar, M. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04293-7 · Cited by 14
Improving cellular fitness of human stem cell-derived islets under hypoxia
Wang, X., Brielle, S., Kenty, J. H.-R., Korover, N., Bavli, D., Pop, R., & Melton, D. A. (2025) · Nature Communications · doi:10.1038/s41467-025-59924-7 · Cited by 14
Stem-cell-derived beta cells mature metabolically upon murine engraftment
Vähäkangas, E., Saarimäki‐Vire, J., Montaser, H., Lithovius, V., Eurola, S., Ibrahim, H., Kuuluvainen, E., Balboa, D., Katajisto, P., Barsby, T., et al. (2025) · Diabetologia · doi:10.1007/s00125-025-06474-8 · Cited by 13
Stem cell-derived pancreatic beta cells: a step closer to functional diabetes treatment?
Ogieuhi, I. J., Agbo, C. E., Ajekiigbe, V. O., Chidera Stanley Anthony, M., Onyehalu, J. C., Nwankwo, C. K., Agu, M. C., Lema, K. F., Adewole, O. A., Asade, O. O., et al. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-01997-y · Cited by 14
Iorio, C., Rourke, J. L., Wells, L., Sakamaki, J.-I., Moon, E., Hu, Q., Kin, T., & Screaton, R. A. (2021) · Communications Biology · doi:10.1038/s42003-021-02433-2 · Cited by 13
Bartolomé, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010501 · Cited by 15
Sasaki, S., Lee, M. Y. Y., Wakabayashi, Y., Suzuki, L., Winata, H. K., Himuro, M., Matsuoka, T., Shimomura, I., Watada, H., Lynn, F. C., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05662-0 · Cited by 13
Transcriptome-Powered Pluripotent Stem Cell Differentiation for Regenerative Medicine
Ogi, D. A., & Jin, S. (2023) · Cells · doi:10.3390/cells12101442 · Cited by 13
Feng, X., Zhang, H., Yang, S., Cui, D., Wu, Y., Qi, X., & Su, Z. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04999-x · Cited by 13
Hu, M., Cebola, I., Carrat, G., Jiang, S. S., Nawaz, S., Khamis, A., Canouil, M., Froguel, P., Schulte, A., Solimena, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108703 · Cited by 14
CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs
Sakuma, K., Tsubooka-Yamazoe, N., Hashimoto, K., Sakai, N., Asano, S., Watanabe-Matsumoto, S., Watanabe, T., Saito, B., Matsumoto, H., Ueno, H., et al. (2023) · Stem cell research & therapeutics · doi:10.1186/s13287-022-03220-4 · Cited by 12
Hiyoshi, H., Sakuma, K., Asano, S., Napier, S. C., Konagaya, S., Mochida, T., Ueno, H., Watanabe, T., Kassai, Y., Matsumoto, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2320883121 · Cited by 12
Islet transplantation in immunomodulatory nanoparticle–remodeled spleens
Liu, M., Deng, H., Liu, C., Wang, L., Liao, Z., Li, D., Chen, Y., Li, J., Dong, J., Sun, X., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adj9615 · Cited by 12
Sionov, R. V., & Ahdut-HaCohen, R. (2023) · Biomedicines · doi:10.3390/biomedicines11092558 · Cited by 13
β cell replacement therapy for the cure of diabetes
Lee, J., & Yoon, K. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13884 · Cited by 15
Bru-Tarí, E., Oropeza, D., & Herrera, P. L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.619150 · Cited by 12
Coate, K. C., Cha, J., Shrestha, S., Wang, W., Gonçalves, L. M., Almaça, J., Kapp, M. E., Fasolino, M., Morgan, A., Dai, C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.275719 · Cited by 12
Mar, S., Filatov, E., Sasaki, S., Mojibian, M., Zhang, D., Yang, A., Nian, C., & Lynn, F. C. (2024) · Diabetes · doi:10.2337/db24-0756 · Cited by 11
Ashok, P., Parikh, A., Du, C., & Tzanakakis, E. S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.571425 · Cited by 11
Wild, S. L., & Tosh, D. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200219 · Cited by 11
Goode, R. A., Hum, J. M., & Kalwat, M. A. (2022) · Endocrinology · doi:10.1210/endocr/bqac193 · Cited by 12
Goh, S.-K., Bertera, S., Richardson, T., & Banerjee, I. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acb7bf · Cited by 11
Chendke, G. S., Kharbikar, B. N., Ashe, S., Faleo, G., Sneddon, J. B., Tang, Q., Hebrok, M., & Desai, T. A. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10520 · Cited by 11
Self-citationForward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA
Jeyagaran, A., Urbanczyk, M., Layland, S. L., Weise, F., & Schenke‐Layland, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-64346-4 · Cited by 11
Recent advances and potential applications of human pluripotent stem cell-derived pancreatic β cells
Zhou, Z., Ma, X., & Zhu, S. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa047 · Cited by 11
George, M. N., Leavens, K. F., & Gadue, P. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.682625 · Cited by 11
Dettmer, R., Niwolik, I., Mehmeti, I., Jörns, A., & Naujok, O. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10232-9 · Cited by 11
Optimizing Generation of Stem Cell-Derived Islet Cells
Verhoeff, K. K., Cuesta‐Gomez, N., Jasra, I. T., Marfil‐Garza, B. A., Dadheech, N., & Shapiro, A. M. J. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10391-3 · Cited by 11
Bayly, C. L., Dai, X.-Q., Nian, C., Orban, P. C., Verchere, C. B., MacDonald, P. E., & Lynn, F. C. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102017 · Cited by 10
Tankyrase inhibition promotes endocrine commitment of hPSC-derived pancreatic progenitors
Poon, F., Sambathkumar, R., Korytnikov, R., Aghazadeh, Y., Oakie, A., Misra, P. S., Sarangi, F., & Nostro, M. C. (2024) · Nature Communications · doi:10.1038/s41467-024-53068-w · Cited by 10
Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?
Shalaby, K. E., & Abdelalim, E. M. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00786-8 · Cited by 10
Xu, R., Wang, K., Yao, Z., Zhang, Y., Li, J., Pang, J., Zhou, Y., Wang, K., Liu, D., Zhang, Y., et al. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad033 · Cited by 10
Barra, J. M., KRATZ, A. T., Castro-Gutiérrez, R., Proia, J., Bhardwaj, G., Phelps, E. A., & Russ, H. A. (2024) · Diabetes · doi:10.2337/db24-0346 · Cited by 10
Self-citationPancreas development and the Polycomb group protein complexes
Dumasia, N. P., & Pethe, P. S. (2020) · Mechanisms of Development · doi:10.1016/j.mod.2020.103647 · Cited by 10
Memon, B., & Abdelalim, E. M. (2020) · Methods in molecular biology · doi:10.1007/7651_2020_323 · Cited by 10
Ghezelayagh, Z., Zabihi, M., Ashtiani, M. K., Ghezelayagh, Z., Lynn, F. C., & Tahamtani, Y. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03951-2 · Cited by 13
Enhancing the Functionality of Immunoisolated Human SC‐βeta Cell Clusters through Prior Resizing
Bochenek, M. A., Walters, B., Zhang, J., Fenton, O. S., Facklam, A. L., Kroneková, Z., Pelach, M., Engquist, E. N., Leite, N. C., Morgart, A., et al. (2024) · Small · doi:10.1002/smll.202307464 · Cited by 9
Glucose metabolism and regulation in establishing human stem cell-derived β cell maturation
Lin, H., Liu, X., Chen, L., Guo, Y., Xu, T., & Liu, H. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115892 · Cited by 10
Implanted flexible electronics reveal principles of human islet cell electrical maturation
Li, Q., Liu, R., Lin, Z., Zhang, X., Wang, W., Galicia-Silva, I. M., Liu, M., Gao, Z., Pollock, S. D., Alvarez‐Dominguez, J. R., et al. (2026) · Science · doi:10.1126/science.aeb3295 · Cited by 9
Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation
Li, L., Zhitao, L., Nannan, C., Mingzhu, H., Xiaoping, H., Dongsheng, H., Pan, Z., & Lu, X. (2022) · Stem Cells International · doi:10.1155/2022/1172795 · Cited by 9
AT7867 promotes pancreatic progenitor differentiation of human iPSCs
Cuesta‐Gomez, N., Verhoeff, K. K., Dadheech, N., Pawlick, R. L., Marfil‐Garza, B. A., Razavy, H., & Shapiro, A. M. J. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.10.005 · Cited by 9
The application of organoid models in research into metabolic diseases
Song, Y., Lu, S., Gao, F., Wei, T., & Ma, W. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15390 · Cited by 9
Untangling the genetics of beta cell dysfunction and death in type 1 diabetes
Robertson, C. C., Elgamal, R. M., Henry-Kanarek, B. A., Arvan, P., Chen, S., Dhawan, S., Eizirik, D. L., Kaddis, J. S., Vahedi, G., Parker, S. C. J., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101973 · Cited by 12
Nair, A. K., Traurig, M. T., Sutherland, J. R., Muller, Y. L., Grellinger, E. D., Saporito, L., Nelson, R. G., Bogardus, C., & Baier, L. J. (2022) · Cells · doi:10.3390/cells11091446 · Cited by 9
From glucose sensing to exocytosis: takes from maturity onset diabetes of the young
Samadli, S., Zhou, Q., Zheng, B., Gu, W., & Zhang, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1188301 · Cited by 9
A map of β-cell differentiation pathways supports cell therapies for diabetes
Theis, F. J., & Lickert, H. (2019) · Nature · doi:10.1038/d41586-019-01211-9 · Cited by 9
Clinically compliant enrichment of human pluripotent stem cell–derived islets
Rajaei, B., Munoz-Garcia, A., Juksar, J., Doppenberg, J. B., Paz-Barba, M., Boot, F., de Vos, W., Mulder, A. A., Lambregtse, F., Daleman, L., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adl4390 · Cited by 8
FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction
Tacto, C., Tahbaz, M., Salib, A., Wang, S., Cayabyab, F., Choi, J., Kim, K. A., Hamba, Y., Perez, H. D., Gershon, P. D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60188-4 · Cited by 9
Han, J., Lim, D., & Yang, K. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251373039 · Cited by 8
Brown, M. E., Barra, J. M., Pina, M., Proia, J., Brusko, T. M., & Russ, H. A. (2025) · Science Advances · doi:10.1126/sciadv.adx9755 · Cited by 8
Self-citationLietzke, A. C., Walker, E. M., Bealer, E. J., Crumley, K. M., King, J. L., Stendahl, A. M., Zhu, J., Pearson, G. L., Levi-D’Ancona, E., Henry-Kanarek, B. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66022-1 · Cited by 9
Dandapani, S., & Hwang, Y. (2026) · Mechanobiology · doi:10.1177/29780241261418480 · Cited by 8
Reprogramming—Evolving Path to Functional Surrogate β-Cells
Kalo, E., Read, S. A., & Ahlenstiel, G. (2022) · Cells · doi:10.3390/cells11182813 · Cited by 8
Loss of ZNF148 enhances insulin secretion in human pancreatic β cells
de Klerk, E., Xiao, Y., Emfinger, C. H., Keller, M. P., Berrios, D. I., Loconte, V., Ekman, A. A., White, K. L., CARDONE, R. L., Kibbey, R. G., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.157572 · Cited by 8
Self-citationJarc, L., Bandral, M., Zanfrini, E., Lesche, M., Kufrin, V., Sendra, R., Pezzolla, D., Giannios, I., Khattak, S., Neumann, K., et al. (2023) · eLife · doi:10.7554/elife.89962 · Cited by 10
Chen, Z., Stoukides, D. M., & Tzanakakis, E. S. (2024) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00653 · Cited by 8
Scaling Insulin-Producing Cells by Multiple Strategies
Choi, J. S., Cayabyab, F., Perez, H., & Yoshihara, E. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1910 · Cited by 8
Tanaka, A., Watanabe, A., Nakano, Y., Matsumoto, M., Okazaki, Y., & Miyajima, A. (2020) · Genes to Cells · doi:10.1111/gtc.12759 · Cited by 8
Magaletta, M. E., Siller, R., & Maehr, R. (2020) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.01.004 · Cited by 6
Carrasco, M., Wang, C., Søviknes, A. M., Bjørlykke, Y., Abadpour, S., Paulo, J. A., Tjora, E., Njølstad, P. R., Ghabayen, J., Nermoen, I., et al. (2022) · Diabetes · doi:10.2337/db20-1279 · Cited by 8
Lithovius, V., & Otonkoski, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.837450 · Cited by 8
Generating pancreatic beta-like cells from human pluripotent stem cells
Lim, L. Y., Ching, C., Kong, D., Chan, S., & Teo, A. K. K. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2022.02.011 · Cited by 8
Pancreas transplant versus islet transplant versus insulin pump therapy: in which patients and when?
Tamburrini, R., & Odorico, J. S. (2021) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000857 · Cited by 8
Oakie, A., & Nostro, M. C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636182 · Cited by 8
Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturationPreprint
Li, Q., Liu, R., Lin, Z., Zhang, X., Galicia-Silva, I. M., Pollock, S. D., Alvarez‐Dominguez, J. R., & Jia Liu, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.18.585551 · Cited by 8
Yehya, H., Wells, A., Majcher, M., Nakhwa, D., King, R., Senturk, F., Padmanabhan, R., Jensen, J., & Bukys, M. A. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03973-0 · Cited by 7
Nakayama, M., Moriya, Y., Ueno, H., Watanabe, T., Hirabayashi, H., & Yamamoto, S. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101538 · Cited by 7
Recent Developments in Islet Biology: A Review With Patient Perspectives
Basu, L., Bhagat, V., Ching, M. E. A., Giandomenico, A. D., Dostie, S., Greenberg, D. T., Greenberg, M., Hahm, J., Hilton, N. Z., Lamb, K., et al. (2022) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2022.11.003 · Cited by 7
Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
Triolo, T. M., Matuschek, J. Q., Castro-Gutiérrez, R., Shilleh, A. H., Williams, S. P. M., Hansen, M. S., McDaniel, K. A., Barra, J. M., Michels, A. W., & Russ, H. A. (2022) · Cells · doi:10.3390/cells11233845 · Cited by 7
Self-citationRamzy, A., Saber, N., Bruin, J. E., Thompson, D. M., Kim, P. T. W., Warnock, G. L., & Kieffer, T. J. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad499 · Cited by 7
PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system
Zhao, J., Liang, S., Cen, H. H., Li, Y., Baker, R. K., Ruprai, B., Gao, G., Zhang, C., Ren, H., Tang, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50109-2 · Cited by 7
Emerging Diabetes Therapies: Regenerating Pancreatic β Cells
Zhang, H., Wei, Y., Wang, Y., Liang, J., Hou, Y., Nie, X., & Hou, J. (2024) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2024.0041 · Cited by 7
Self-citationHuman Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants
Heller, S., Melzer, M. K., Azoitei, N., Julier, C., & Kleger, A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.648284 · Cited by 8
González‐Moro, I., García‐Etxebarria, K., Mendoza, L. M., Fernández‐Jiménez, N., Mentxaka, J., Olazagoitia‐Garmendia, A., Arroyo, M. N., Sawatani, T., Moreno‐Castro, C., Vinci, C., et al. (2023) · Advanced Science · doi:10.1002/advs.202300063 · Cited by 7
Sepyani, S., Momenzadeh, S., Safabakhsh, S., Nedaeinia, R., & Salehi, R. (2023) · SLAS DISCOVERY · doi:10.1016/j.slasd.2023.11.002 · Cited by 7
Bioartificial pancreas: challenges and progress
de Vos, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00037-x · Cited by 7
Engineering-inspired approaches to study β-cell function and diabetes
Lewis, P. L., & Wells, J. M. (2021) · Stem Cells · doi:10.1002/stem.3340 · Cited by 8
Metadata
- Authors
- Nair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., Puri, S., Xing, Y., Wang, Y., Szot, G. L., Oberholzer, J., Bhushan, A., & Hebrok, M.
- Affiliations
- University of California, San Francisco (US)
- Lawrence Berkeley National Laboratory (US)
- University of Virginia (US)
- Corresponding author
- Hebrok, Matthias
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2019-02
- Volume
- 21
- Issue
- 2
- Pages
- 263-274
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC6746427
- OpenAlex
- W2913837249
- Cited by
- 472
- References
- 45
- Citations by year
- 2026: 39 · 2025: 51 · 2024: 67 · 2023: 69 · 2022: 73 · 2021: 85 · 2020: 57 · 2019: 31
- FWCI
- 59.01
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-03-26)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (DK108666)
- University of California, San Francisco
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK108666, P30DK063720, R01DK105831)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- beta cell maturation, stem cell-derived beta cells, human embryonic stem cells, insulin secretion, calcium signaling, glucose-stimulated insulin secretion, islet transplantation
- MeSH terms
- Human Embryonic Stem Cells, Insulin Secretion, Animals, Cell Differentiation, Cells, Cultured, Fibroblasts, Glucose, Humans, Islets of Langerhans, Mitochondria, Insulin-Secreting Cells, Mice, Embryonic Stem Cells, Endocrine Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
