Hebrok, Matthias

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell

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Notochord repression of endodermal Sonic hedgehog permits pancreas development

Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development

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Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro

Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, T., Puri, S., Haataja, L., Cirulli, V., et al. (2015) · The EMBO Journal

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Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

Nair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., et al. (2019) · Nature Cell Biology

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Regulation of pancreas development by hedgehog signaling

Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development

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Notochord to endoderm signaling is required for pancreas development

Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development

Developmental Biology and Gene RegulationPancreatic function and diabetes

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Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice†‡

Sekine, S., Lan, B. Y., Bedolli, M., Feng, S., & Hebrok, M. (2006) · Hepatology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

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How Does Type 1 Diabetes Develop?

Atkinson, M. A., Bluestone, J. A., Eisenbarth, G. S., Hebrok, M., Herold, K. C., Accili, D., Pietropaolo, M., Arvan, P. R., Von Herrath, M., Markel, D. S., et al. (2011) · Diabetes

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Activin receptor patterning of foregut organogenesis

Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development

Developmental Biology and Gene RegulationPancreatic function and diabetes

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The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology

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Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

Roy, N., Malik, S., Villanueva, K. E., Urano, A., Lu, X., Von Figura, G., Seeley, E. S., Dawson, D. W., Collisson, E. A., & Hebrok, M. (2015) · Genes & Development

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Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development

Landsman, L., Nijagal, A., Whitchurch, T. J., VanderLaan, R. L., Zimmer, W. E., MacKenzie, T. C., & Hebrok, M. (2011) · PLoS Biology

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Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

von Figura, G., Morris, J. P., Wright, C. V. E., & Hebrok, M. (2014) · Gut

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Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy

Nair, G. G., Tzanakakis, E. S., & Hebrok, M. (2020) · Nature Reviews Endocrinology

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Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection

Parent, A. V., Faleo, G., Chavez, J., Saxton, M., Berrios, D. I., Kerper, N. R., Tang, Q., & Hebrok, M. (2021) · Cell Reports

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Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant

Faleo, G., Russ, H. A., Wisel, S., Parent, A. V., Nguyen, V., Nair, G. G., Freise, J. E., Villanueva, K. E., Szot, G. L., Hebrok, M., et al. (2017) · Stem Cell Reports

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