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The cell cycle in stem cell proliferation, pluripotency and differentiation
Open accessAbstract
Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryonic neural stem/progenitor cells. In this Review, the authors discuss how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification.
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The role of ubiquitination in tumorigenesis and targeted drug discovery
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Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
Pellarin, I., Dall’Acqua, A., Favero, A., Segatto, I., Rossi, V., Crestan, N., Karimbayli, J., Belletti, B., & Baldassarre, G. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02080-z · Cited by 304
Chromatin replication and epigenetic cell memory
Stewart-Morgan, K. R., Petryk, N., & Groth, A. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0487-y · Cited by 287
Somatic mutations alter the differentiation outcomes of iPSC-derived neurons
Puigdevall, P., Jerber, J., Danecek, P., Castellano, S., & Kilpinen, H. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100280 · Cited by 29
Nakagawa, T., Hattori, S., Nobuta, R., Kimura, R., Nakagawa, M., Matsumoto, M., Nagasawa, Y., Funayama, R., Miyakawa, T., Inada, T., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101030 · Cited by 27
Metadata
- Authors
- Liu, L., Michowski, W., Kolodziejczyk, A., & Sicinski, P.
- Venue
- Nature Cell Biology
- Published
- 2019-09
- Volume
- 21
- Issue
- 9
- Pages
- 1060-1067
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2970684207
- Cited by
- 414
- References
- 137
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- green
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