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Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

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Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

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RNA at DNA Double‐Strand Breaks: The Challenge of Dealing with DNA:RNA Hybrids

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Fluorescence and phosphorescence lifetime imaging reveals a significant cell nuclear viscosity and refractive index changes upon DNA damage

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PARP trapping is governed by the PARP inhibitor dissociation rate constant

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Roles of Phase Separation for Cellular Redox Maintenance

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Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases

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Mediator Roles Going Beyond Transcription

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Non-coding RNAs in chromatin folding and nuclear organization

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RAP80 phase separation at DNA double-strand break promotes BRCA1 recruitment

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Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

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A biophysical basis for the spreading behavior and limited diffusion of Xist

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Compartmentalization of the DNA damage response: Mechanisms and functions

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Integration of DNA damage responses with dynamic spatial genome organization

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Long noncoding RNA and phase separation in cellular stress response

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The ins and outs of CENP-A: Chromatin dynamics of the centromere-specific histone

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Repair Foci as Liquid Phase Separation: Evidence and Limitations

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A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates

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HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

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The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance

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The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair

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Phase separation-mediated biomolecular condensates and their relationship to tumor

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A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization

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Onco-condensates: formation, multi-component organization, and biological functions

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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Physical observables to determine the nature of membrane-less cellular sub-compartments

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DNA repair and anti-cancer mechanisms in the long-lived bowhead whalePreprint

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The Role of Small Noncoding RNA in DNA Double-Strand Break Repair

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CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway

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Phase separation in gene transcription control

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Chemical-induced phase transition and global conformational reorganization of chromatin

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SARS-CoV-2 and the DNA damage response

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The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks

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Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair

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Driving forces of RNA condensation revealed through coarse-grained modeling with explicit Mg 2+

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DNA Processing in the Context of Noncoding Transcription

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Non-homologous end-joining at challenged replication forks: an RNA connection?

Audoynaud, C., Vagner, S., & Lambert, S. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.06.010 · Cited by 23

Multi-scale dynamics of heterochromatin repair

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DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation

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RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei

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One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA

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DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

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Making Connections: Integrative Signaling Mechanisms Coordinate DNA Break Repair in Chromatin

Sanchez, A. R., Lee, D., Kim, D. I., & Miller, K. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.747734 · Cited by 25

DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells

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Phase Separation-Mediated Chromatin Organization and Dynamics: From Imaging-Based Quantitative Characterizations to Functional Implications

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Biomolecular Condensation: A New Phase in Cancer Research

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Break‐induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?

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Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency

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Nuclear actin: The new normal

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Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

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Role of phase partitioning in coordinating DNA damage response: focus on the Apurinic Apyrimidinic Endonuclease 1 interactome

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Arabidopsis lamin-like proteins CRWN1 and CRWN2 interact with SUPPRESSOR OF NPR1-1 INDUCIBLE 1 and RAD51D to prevent DNA damage

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Trnp1 organizes diverse nuclear membrane‐less compartments in neural stem cells

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Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks

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DNA damage reduces heterogeneity and coherence of chromatin motions

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Phase separation in DNA double-strand break response

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The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair

Jimeno, S., Balestra, F. R., & Huertas, P. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.664872 · Cited by 18

Impacts of chromatin dynamics and compartmentalization on DNA repair

Yasuhara, T., & Zou, L. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103162 · Cited by 18

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

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Genome-wide profiling of DNA repair proteins in single cells

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A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements

Bai, X., Li, F., & Zhang, Z. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.005 · Cited by 19

The chromatin remodeler RSF1 coordinates epigenetic marks for transcriptional repression and DSB repair

Min, S., Lee, H., Ji, J., Heo, Y., Kim, Y., Chae, S., Choi, Y. W., Kang, H. C., Nakanishi, M., & Cho, H. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1093 · Cited by 18

Understanding DNA organization, damage, and repair with super-resolution fluorescence microscopy

Miriklis, E. L., Rozario, A. M., Rothenberg, E., Bell, T. D. M., & Whelan, D. R. (2021) · Methods and Applications in Fluorescence · doi:10.1088/2050-6120/abf239 · Cited by 21

MYLK-AS1 Enhances Glutamine Metabolism to Promote EGFR Inhibitor Resistance in Non–Small Cell Lung Cancer

Qu, T., Song, L., Xu, J., Lu, X., Yin, D., Dai, J., Zhang, C., Guo, R., & Zhang, E. (2025) · Cancer Research · doi:10.1158/0008-5472.can-23-3748 · Cited by 17

Laser microirradiation as a tool to investigate the role of liquid-liquid phase separation in DNA damage repair

Levone, B. R., Lombardi, S., & Barabino, S. M. L. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101146 · Cited by 20

Phase-separation antagonists potently inhibit transcription and broadly increase nucleosome density

Meduri, R., Rubio, L. S., Mohajan, S., & Gross, D. S. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102365 · Cited by 21

Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

Kolobynina, K. G., Rapp, A. W., & Cardoso, M. C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.928113 · Cited by 17

The GATAD2B-NuRD complex drives DNA:RNA hybrid-dependent chromatin boundary formation upon DNA damage

Liu, Z., Ajit, K., Wu, Y., Zhu, W., & Gullerová, M. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00111-7 · Cited by 16

NEAT1 promotes genome stability via m 6 A methylation-dependent regulation of CHD4Preprint

Mamontova, V., Trifault, B., Gribling-Burrer, A.-S., Bohn, P. S., Boten, L., Preckwinkel, P., Gallant, P., Solvie, D., Ade, C. P., Papadopoulos, D., et al. (2024) · Genes & Development · doi:10.1101/gad.351913.124 · Cited by 16

Known types of membrane-less organelles and biomolecular condensates

Darling, A. L., & Uversky, V. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823967-4.00002-6 · Cited by 15

DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue

Modafferi, S., Farina, S., Esposito, F., Brandi, O., Salvio, M. D., Valle, I. D., D’Uva, S., Scarian, E., Cicio, G., Riccardi, A., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01530-7 · Cited by 16

Architectural RNAs: blueprints for functional membraneless organelle assembly

Hirose, T., Fujiwara, N., Ninomiya, K., Yamamoto, T., Nakagawa, S., & Yamazaki, T. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.05.007 · Cited by 15

Biomolecular Condensates: Structure, Functions, Methods of Research

Gorsheneva, N. A., Sopova, J. V., Azarov, V. V., Grizel, A. V., & Rubel, A. A. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924140116 · Cited by 13

Active RNA synthesis patterns nuclear condensatesPreprint

Banani, S. F., Goychuk, A., Natarajan, P., Zheng, M., Dall’Agnese, G., Henninger, J. E., Mehran Kardar, A., Young, R. A., & Chakraborty, A. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.12.614958 · Cited by 14

Liquid-liquid phase separation of membrane-less condensates: from biogenesis to function

Guan, H., Wang, H., Cai, X. M., Wang, J., Chai, Z., Wang, J., Wang, H., Zhang, M., Wu, Z., Zhu, J., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600430 · Cited by 13

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

Schellenbauer, A., Guilly, M., Grall, R., Bars, R. L., Paget, V., Kortulewski, T., Sutcu, H. H., Mathé, C., Hullo, M., Biard, D. S. F., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab980 · Cited by 17

Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

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Wogonin protects against bleomycin-induced mouse pulmonary fibrosis via the inhibition of CDK9/p53-mediated cell senescence

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Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation

Li, J., Gao, J., & Wang, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212271 · Cited by 13

Enhancers are genes that express organizational RNAs

Mattick, J. S. (2023) · Frontiers in RNA Research · doi:10.3389/frnar.2023.1194526 · Cited by 10

RNA in DNA repair

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Liquid-liquid phase separation in aging: Novel insights in the pathogenesis and therapeutics

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Biomolecular condensates: A new lens on cancer biology

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APE1 condensation in nucleoli of non-cancer cells depends on rRNA transcription and forming G-quadruplex RNA structures

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A de novo Transcription-Dependent TAD Boundary Underpins Critical Multiway Interactions During Antibody Class Switch Recombination

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