The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.
p120-catenin-dependent collective brain infiltration by glioma cell networks
Open accessAbstract
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium transients and mediate directional persistence. Downregulation of p120-catenin compromises cell-cell interaction and communication, disrupts collective networks, and both the cadherin and RhoA binding domains of p120-catenin are required for network formation and migration. Deregulating p120-catenin further prevents diffuse glioma cell infiltration of the mouse brain with marginalized microlesions as the outcome. Transcriptomics analysis has identified p120-catenin as an upstream regulator of neurogenesis and cell cycle pathways and a predictor of poor clinical outcome in glioma patients. Collective glioma networks infiltrating the brain thus depend on adherens junctions dynamics, the targeting of which may offer an unanticipated strategy to halt glioma progression.
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“Interstitial compartments are organized into various 3D architectures, including fibrillar porous networks or aligned bundles, heterogeneous in density, topology, and stiffness [11,12].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [12]
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Metadata
- Authors
- Gritsenko, P. G., Atlasy, N., Dieteren, C. E. J., Navis, A. C., Venhuizen, J.-H., Veelken, C., Schubert, D., Acker-Palmer, A., Westerman, B. A., Wurdinger, T., Leenders, W., Wesseling, P., Stunnenberg, H. G., & Friedl, P.
- Affiliations
- Radboud University Medical Center (NL)
- Radboud University Nijmegen (NL)
- Karolinska Institutet (SE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Princess Máxima Center (NL)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Friedl, Peter
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2020-01
- Volume
- 22
- Issue
- 1
- Pages
- 97-107
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC6952556
- OpenAlex
- W2997878069
- Cited by
- 112
- References
- 82
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 15 · 2020: 16
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Brain Tumour Charity (GN-000429)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (918.11.626, 863.13.019)
- National Cancer Institute (U54CA210184, P30CA016672)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- p120 catenin, glioma, brain infiltration, collective cell migration, multicellular networks, N-cadherin, β-catenin, adherens junctions, intercellular calcium signaling, RhoA, directional persistence, intercellular communication, neurogenesis, cell cycle, clinical outcome prediction
- MeSH terms
- Delta Catenin, Animals, Brain, Cell Adhesion, Glioma, Phosphoproteins, Phosphorylation, Down-Regulation, Cadherins, Adherens Junctions, Cell Line, Tumor, Catenins
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