Microtubule lattice state regulates Rho GTPase

Microtubules as a target for anticancer drugs

Jordan, M. A., & Wilson, L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1317 · Cited by 4,534 · see citing works

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014) · Cell · doi:10.1016/j.cell.2014.03.053 · Cited by 696 · see citing works

Actin–microtubule crosstalk in cell biology

Dogterom, M., & Koenderink, G. H. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0067-1 · Cited by 563 · see citing works

A Compressive Review about Taxol®: History and Future Challenges

Gallego‐Jara, J., Terol, G. L., Martínez, R. A. S., Cánovas, M., & Puente, T. D. D. (2020) · Molecules · doi:10.3390/molecules25245986 · Cited by 356 · see citing works

Mitosis is not a key target of microtubule agents in patient tumors

Komlodi-Pasztor, E., Sackett, D., Wilkerson, J., & Fojo, T. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.228 · Cited by 312 · see citing works

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

Danowski, B. A. (1989) · Journal of Cell Science · doi:10.1242/jcs.93.2.255 · Cited by 308 · see citing works

The role of tubulin–tubulin lattice contacts in the mechanism of microtubule dynamic instability

Manka, S. W., & Moores, C. A. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0087-8 · Cited by 159 · see citing works

Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck

Tang, P. A., Siu, L. L., Chen, E. X., et al. (2007) · Investigational New Drugs · doi:10.1007/s10637-007-9098-8 · Cited by 82 · see citing works

Structural basis of microtubule-mediated signal transduction

Choi, S. R., Blum, T. B., Giono, M., Roy, B., Vakonakis, I., Schmid, D., Oelgarth, N., Ranganathan, A., Gossert, A. D., Shivashankar, G. V., et al. (2026) · Cell · doi:10.1016/j.cell.2025.11.011 · Cited by 14 · see citing works

Reflections on My Life with Taxol

Horwitz, S. B. (2019) · Cell · doi:10.1016/j.cell.2019.03.031 · Cited by 6 · see citing works

An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy

LUO, J., Khoo, C. J., Chen, W., Liu, Z., Li, B., Lau, W. S., Li, X., & Ti, S.-C. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02204-2 · Cited by 6 · see citing works

Resolving paclitaxel efficacy

Al‐Bassam, J., & Taheri, A. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02208-y · Cited by 1 · see citing works

Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease

Janke, C., Akhmanova, A. S., Bartolini, F., Bodakuntla, S., Bene, F. D., Hamel, V., Mitchison, T. J., Müller‐Reichert, T., Nédélec, F., Nogales, E., et al. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-01011-w · Cited by 1 · see citing works

Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling

Meiring, J. C. M., Mahapatra, V., Liu, R., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Pelster José, A., Karhanova, A., Metallidou, I., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02079-4

Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling

Meiring, J. C. M., Mahapatra, V., Liu, R., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Pelster José, A., Karhanova, A., Metallidou, I., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02079-4

Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA SignalingPreprint

Meiring, J. C. M., Mahapatra, V., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Jose, A. P., Karhanova, A., Metallidou, I., Moore, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.20.695343

Taxanes convert regions of perturbed microtubule growth into rescue sites

Rai, A., Liu, T., Glauser, S., Katrukha, E. A., Estévez‐Gallego, J., Rodríguez-García, R., Fang, W., Díaz, J. F., Steinmetz, M. O., Altmann, K., et al. (2019) · Nature Materials · doi:10.1038/s41563-019-0546-6 · Cited by 56 · see citing works

TXR1-mediated thrombospondin repression: a novel mechanism of resistance to taxanes?Preprint

van Amerongen, R., & Berns, A. M. (2006) · Genes & Development · doi:10.1101/gad.1460806 · Cited by 19 · see citing works

Taxanes and other microtubule stabilizing agents.

Sackett, D. L., & Fojo, T. (1999) · PubMed · Cited by 10 · see citing works