Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 257

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Practical and regioselective amination of arenes using alkyl amines

Open access
Ruffoni, Alessandro, Juliá, Fabio, Svejstrup, Thomas D., McMillan, Alastair J., Douglas, James J., Leonori, Daniele·2019·Nature Chemistry
DOI 10.1038/s41557-019-0254-5
Open this paper in CoChat — free account

Abstract

The formation of carbon–nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chemicals to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chemical syntheses in academia and industry. In general, these molecules are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C–H bond (that is, a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochemicals, peptides, chiral catalysts, polymers and organometallic complexes.The synthesis of aryl amines is traditionally achieved through aromatic nitration or transition metal-catalysed cross coupling. Now, photocatalysis provides a route for the direct and selective C–H amination of aromatics with alkyl amines, without the need for pre-functionalization. This reaction tolerates a variety of functional groups and can be used for late-stage modification.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41557-019-0254-5

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 33 references

Cited by

See all 257

Metadata

Authors
Ruffoni, A., Juliá, F., Svejstrup, T. D., McMillan, A. J., Douglas, J. J., & Leonori, D.
Venue
Nature Chemistry
Publisher
Springer Science and Business Media LLC
Published
2019-04-22
Volume
11
Issue
5
Pages
426-433
ISSN
  • 1755-4330 (ISSN-L)
  • 1755-4349
DOI
10.1038/s41557-019-0254-5
OpenAlex
W2935710415
Cited by
257
References
33
FWCI
14.09
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Practical and regioselective amination of arenes using alkyl amines. https://app.cochat.ai/papers/10.1038/s41557-019-0254-5
The paper
Ruffoni, A., Juliá, F., Svejstrup, T. D., McMillan, A. J., Douglas, J. J., & Leonori, D. (2019). Practical and regioselective amination of arenes using alkyl amines. Nature Chemistry. https://doi.org/10.1038/s41557-019-0254-5

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.