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Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease
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Individuals with high genetic predisposition to late-onset diseases tend to have more children, reduced childlessness and younger ages at first birth.
“Individuals with high genetic predisposition to late-onset diseases tend to have more children, reduced childlessness and younger ages at first birth, suggesting early reproductive advantages of these alleles19,22,75.”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [75]
These alleles have early reproductive advantages.
“suggesting early reproductive advantages of these alleles19,22,75”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [75]
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Research works printed but not linked: 7
- Long, E. & Zhang, J. Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-019-0925-z (2019). · DOI
- Rodríguez, J. A. et al. Antagonistic pleiotropy and mutation accumulation influence human senescence and disease. Nat. Ecol. Evol. 1, 55 (2017). · DOI · Paper page
- Williams, G. C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398–411 (1957). · DOI · Paper page
- Charlesworth, B. Evolution in Age-Structured Populations (Cambridge Univ. Press, 1994). · DOI · Paper page
- Flatt, T. & Partridge, L. Horizons in the evolution of aging. BMC Biol. 16, 93 (2018). · DOI
- Wachter, K. W., Steinsaltz, D. & Evans, S. N. Evolutionary shaping of demographic schedules. Proc. Natl Acad. Sci. USA 111, 10846–10853 (2014). · DOI · Paper page
- Austad, S. N. & Hoffman, J. M. Is antagonistic pleiotropy ubiquitous in aging biology?. Evol. Med. Public Health 2018, 287–294 (2018). · DOI
Cited by
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Brigos-Barril, E., Vasallo, C., Farré, X., Morcillo-Suárez, C., Polo-Alonso, S., Rodríguez-Fernández, B., Valenzuela, A., Sarabia, C., Bosch, E., Laayouni, H., et al. (2026) · Nature Ecology & Evolution · doi:10.1038/s41559-026-03140-z · Cited by 6
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Metadata
- Authors
- Rodríguez, J. A., Farré, X., Muntané, G., Marigorta, U. M., Hughes, D. A., Spataro, N., Bosch, E., & Navarro, A.
- Venue
- Nature Ecology & Evolution
- Published
- 2019-06-24
- Volume
- 3
- Issue
- 7
- Pages
- 994-995
- ISSN
- 2397-334X
- Cited by
- 7
- References
- 0
- Language
- en
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