Cited by 274Protist diversity and phylogenyGenomics and Phylogenetic StudiesOrigins and Evolution of Life

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Phylogenomics provides robust support for a two-domains tree of life

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Williams, Tom A., Cox, Cymon J., Foster, Peter G., Szöllősi, Gergely J., Embley, T. Martin·2019·Nature Ecology & Evolution

DOI 10.1038/s41559-019-1040-xPMC PMC6942926

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Abstract

Hypotheses about the origin of eukaryotic cells are classically framed within the context of a universal 'tree of life' based on conserved core genes. Vigorous ongoing debate about eukaryote origins is based on assertions that the topology of the tree of life depends on the taxa included and the choice and quality of genomic data analysed. Here we have reanalysed the evidence underpinning those claims and apply more data to the question by using supertree and coalescent methods to interrogate >3,000 gene families in archaea and eukaryotes. We find that eukaryotes consistently originate from within the archaea in a two-domains tree when due consideration is given to the fit between model and data. Our analyses support a close relationship between eukaryotes and Asgard archaea and identify the Heimdallarchaeota as the current best candidate for the closest archaeal relatives of the eukaryotic nuclear lineage.

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Authors: Williams, T. A., Cox, C. J., Foster, P. G., Szöllősi, G. J., & Embley, T. M.
Affiliations: University of Bristol (GB)
University of Algarve (PT)
Natural History Museum (GB)
Eötvös Loránd University (HU)
Newcastle University (GB)
Corresponding author: Williams, Tom A.
Embley, T. Martin
ORCID: Williams, Tom A.
Cox, Cymon J.
Foster, Peter G.
Szöllősi, Gergely J.
Embley, T. Martin
Venue: Nature Ecology & Evolution
Publisher: Springer Science and Business Media LLC
Published: 2019-12-09
Volume: 4
Issue: 1
Pages: 138-147
ISSN: 2397-334X (ISSN-L)
DOI: 10.1038/s41559-019-1040-x
PMC: PMC6942926
OpenAlex: W2993939447
Cited by: 274
References: 93
Citations by year: 2026: 20 · 2025: 36 · 2024: 38 · 2023: 31 · 2022: 57 · 2021: 48 · 2020: 41 · 2019: 3
FWCI: 12.32
Type: journal article
Language: en
Update notices: correction (2020-10-19)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Ecology & Evolution (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Bristol Research (University of Bristol) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Natural Environment Research Council (NE/P00251X/1, NE/M015831/1)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Keywords: eukaryotic origin, archaea, eukaryotes, Asgard archaea, coalescent methods, gene family phylogeny
MeSH terms: Archaea, Eukaryotic Cells, Phylogeny, Genomics, Eukaryota

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