The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
Open accessAbstract
Classic embryological studies have successfully applied genetics and cell biology principles to understand embryonic development. However, it remains unresolved how mechanics, as an integral driver of development, is involved in controlling tissue-scale cell fate patterning. Here we report a micropatterned human pluripotent stem (hPS)-cell-based neuroectoderm developmental model, in which pre-patterned geometrical confinement induces emergent patterning of neuroepithelial and neural plate border cells, mimicking neuroectoderm regionalization during early neurulation in vivo. In this hPS-cell-based neuroectoderm patterning model, two tissue-scale morphogenetic signals—cell shape and cytoskeletal contractile force—instruct neuroepithelial/neural plate border patterning via BMP-SMAD signalling. We further show that ectopic mechanical activation and exogenous BMP signalling modulation are sufficient to perturb neuroepithelial/neural plate border patterning. This study provides a useful microengineered, hPS-cell-based model with which to understand the biomechanical principles that guide neuroectoderm patterning and hence to study neural development and disease.Mechanical cues play critical roles in embryonic development. A micropatterned neuroectoderm developmental model based on human pluripotent stem cells now reveals how morophogenetic signals such as cell shape and contractility regulate neural tissue development.
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Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Cerebral organoids model human brain development and microcephaly
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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
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Self-citationSelf-formation of optic cups and storable stratified neural retina from human ESCs
Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., & Sasai, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.009 · Cited by 1,447
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
Warmflash, A., Sorre, B., Etoc, F., Siggia, E. D., & Brivanlou, A. H. (2014) · Nature Methods · doi:10.1038/nmeth.3016 · Cited by 885
Neural induction: old problem, new findings, yet more questions
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Self-citationSelf-organizing human cardiac microchambers mediated by geometric confinement
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Cited by
Engineering Stem Cell Self-organization to Build Better Organoids
Brassard, J. A., & Lutolf, M. P. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.005 · Cited by 373
Human neural tube morphogenesis in vitro by geometric constraints
Karzbrun, E., Khankhel, A. H., Megale, H. C., Glasauer, S. M. K., Wyle, Y., Britton, G., Warmflash, A., Kosik, K. S., Siggia, E. D., Shraiman, B. I., et al. (2021) · Nature · doi:10.1038/s41586-021-04026-9 · Cited by 246
Kim, Y., Jang, H., Seo, K., Kim, J. H., Lee, B., Cho, H. M., Kim, H. J., Yang, E., Kim, H., Gim, J.-A., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.005 · Cited by 33
Metadata
- Authors
- Xue, X., Sun, Y., Resto-Irizarry, A. M., Yuan, Y., Aw Yong, K. M., Zheng, Y., Weng, S., Shao, Y., Chai, Y., Studer, L., & Fu, J.
- Venue
- Nature Materials
- Published
- 2018-05-21
- Volume
- 17
- Issue
- 7
- Pages
- 633-641
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2804583160
- Cited by
- 210
- References
- 8
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Xue, X., Sun, Y., Resto-Irizarry, A. M., Yuan, Y., Aw Yong, K. M., Zheng, Y., Weng, S., Shao, Y., Chai, Y., Studer, L., & Fu, J. (2018). Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nature Materials. https://doi.org/10.1038/s41563-018-0082-9
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