Cited by 280Cellular Mechanics and InteractionsImmune Response and InflammationNF-κB Signaling Pathways

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Spatial confinement downsizes the inflammatory response of macrophages

Open access

Jain, Nikhil, Vogel, Viola·2018·Nature Materials

DOI 10.1038/s41563-018-0190-6PMC PMC6615903

Open this paper in CoChat — free account

Abstract

Macrophages respond to chemical/metabolic and physical stimuli, but their effects cannot be readily decoupled in vivo during pro-inflammatory activation. Here, we show that preventing macrophage spreading by spatial confinement, as imposed by micropatterning, microporous substrates or cell crowding, suppresses late lipopolysaccharide (LPS)-activated transcriptional programs (biomarkers IL-6, CXCL9, IL-1β, and iNOS) by mechanomodulating chromatin compaction and epigenetic alterations (HDAC3 levels and H3K36-dimethylation). Mechanistically, confinement reduces actin polymerization, thereby lowers the LPS-stimulated nuclear translocation of MRTF-A. This lowers the activity of the MRTF-A–SRF complex and subsequently downregulates the inflammatory response, as confirmed by chromatin immunoprecipitation coupled with quantitative PCR and RNA sequencing analysis. Confinement thus downregulates pro-inflammatory cytokine secretion and, well before any activation processes, the phagocytic potential of macrophages. Contrarily, early events, including activation of the LPS receptor TLR4, and downstream NF-κB and IRF3 signalling and hence the expression of early LPS-responsive genes were marginally affected by confinement. These findings have broad implications in the context of mechanobiology, inflammation and immunology, as well as in tissue engineering and regenerative medicine.Physical confinement of macrophages is shown to down-regulate pro-inflammatory gene transcription, lowering pro-inflammatory macrophage activation and phagocytic potential.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41563-018-0190-6

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,710
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Software for Computing and Annotating Genomic Ranges
Lawrence, M. F., Huber, W. K., Pagès, H., Aboyoun, P., Carlson, M. R. J., Gentleman, R. C., Morgan, M. T., & Carey, V. J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003118 · Cited by 4,475

Show all 65 references

Research works printed but not linked: 2

Jain, N., Iyer, K. V., Kumar, A. & Shivashankar, G. V. Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility. Proc. Natl Acad. Sci. USA 110, 11349–11354 (2013). · DOI
Kishi, T., Mayanagi, T., Iwabuchi, S., Akasaka, T. & Sobue, K. Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity. Oncotarget 7, 72113–72130 (2016). · DOI

Sorted by citations

Items 201–280 of 280

Identification of cytochrome P450 2E1 as a novel target in neuroinflammation and development of its inhibitor Q11 as a treatment strategy
Yang, R., Deng, M., Yang, L.-K., Wang, G., Ma, J., Wen, Q., Gao, N., & Qiao, H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.032 · Cited by 6
Temporal Control over Macrophage Phenotype and the Host Response via Magnetically Actuated Scaffolds
Steele, L. A., Spiller, K. L., Cohen, S., Rom, S., & Polyak, B. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00373 · Cited by 5
Mechanoimmunomodulation-based strategy on advancing tissue-engineered nanotopographic structures
Ao, Y., Xia, R., Guo, Y., Cai, Y., Guo, X., Wang, J., & Chen, Z. (2025) · Microstructures · doi:10.20517/microstructures.2024.32 · Cited by 5
Engineering Efferocytosis for Bone Regeneration
Miszuk, J. M., Zhong, L., & Sun, H. (2025) · Macromolecular Bioscience · doi:10.1002/mabi.202500094 · Cited by 5
Physical confinement and phagocytic uptake induce persistent cell migration
Paulson, S. G., Liu, S., & Rotty, J. D. (2025) · Biology Open · doi:10.1242/bio.062021 · Cited by 4
Synthesis and in vitro characterization of naproxen derivatives as novel anti-inflammatory agents
Cao, Y., You, Z., Cao, Y., Li, Y., Wong, V. K. W., Chen, M., Zhang, K., & Liu, W. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138158 · Cited by 4
Soft, precision engineered porous, hydrogel scaffolds mechanically tailored toward applications in the central nervous system
Zhen, L., Darrow, R., Chen, N., Anant, M. M.-G., Tang, C., Gorantla, L., Crawford, L., Dryg, I., & Ratner, B. D. (2024) · Journal of Bioactive and Compatible Polymers · doi:10.1177/08839115241287215 · Cited by 4
Control by cell size
Liu, W. F. (2018) · Nature Materials · doi:10.1038/s41563-018-0225-z · Cited by 4
Suppression of LPS ‐activated inflammatory responses and chromosomal histone modifications in macrophages by micropattern‐induced nuclear deformation
Chu, Q., Han, W., He, Z., Hao, L., & Fu, X. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37617 · Cited by 4
Nanoscale acoustic oscillator for mechanoimmunology: NAOMI
He, Y., Jin, K., Pan, B., Li, K., Mai, J. D. H., Xu, X., Chen, Y., Ma, Z., Yang, K., Yang, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx3851 · Cited by 3
NIR ‐triggered hydrogel with dynamic stiffness via ion chelation to modulate macrophage phenotypes
Yuan, P., Luo, Y., & Ma, L. (2022) · Journal of Polymer Science · doi:10.1002/pol.20220349 · Cited by 3
Mechano-activation of synovial fibroblasts and macrophages during OA progression in the dynamically stiffening synovial microenvironmentPreprint
Kim, S. Y., Farrell, E. C., Burt, K. G., Kwok, B., Liang, Q., Knights, A. J., Sharp, K. L., Nguyen, V., Murphy, L. A., Hu, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.16.706240 · Cited by 3
Comparison of TLR4 Genotype and TLR4 Pathway-Related Cytokines in Different Strains of Mice in Response to Pertussis Toxin Challenge
Wei, J., Wang, L., Wei, C., Guang, J., Wang, H., Zhou, J., Li, H., Ma, X., & Yue, B. (2024) · Genes · doi:10.3390/genes15111435 · Cited by 2
Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices
Sudarsanam, P. K., van Mechelen, R. J. S., Kuijpers, T. J. M., Bertens, C. J. F., Alsema, E. C., Verbakel, J., Beijer, N. R. M., Beckers, H. J. M., & de Boer, J. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.01.012 · Cited by 2
Idiopathic pulmonary fibrosis from a multiscale mechanobiology perspective: Mechanisms and future therapeutic prospects
Xia, T., Wang, X., Yang, Z., & Zhao, R. (2026) · iScience · doi:10.1016/j.isci.2026.115335 · Cited by 4
Mechanobiological engineering strategies for oral and maxillofacial tissue regeneration
Park, J. H., Sagar, V., Leong, K. W., Kim, H., & Kim, H. S. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124158 · Cited by 6
Mechanobiology of inflammation: Pulling the strings of innate immunity
Maniak, M. K., Jenkins, S. J., & Hansen, C. G. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20252269 · Cited by 4
Macro‐ and micro‐scale culture environment differentially regulate the effects of crowding on macrophage function
Hsu, S.-C. J., Luu, T. U., Smith, T. D., & Liu, W. F. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28554 · Cited by 2
Single-cell manipulation by two-dimensional micropatterning
Ma, X., Zhang, H., Deng, S., Sun, Q., Hu, Q., Pan, Y., Hu, F., Lee, I., Xing, F., & Pan, L. (2023) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545823300112 · Cited by 2
Novel Cinnamic Acid Derivatives Containing Naproxen as NLRP3 Inhibitors: Synthesis and Evaluation of Their Biological Activity
Yu, J., You, Z., Wong, V. K. W., Chen, M., & Liu, W. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402700 · Cited by 2
Actin contractility and endocytosis create apico-basal tension gradient in HeLa cellsPreprint
Ghosh, T., Majhi, A., Kundu, A., Banerjee, A., & Sinha, B. (2025) · bioRxiv · doi:10.1101/2025.02.17.638627 · Cited by 2
In Situ Construction of Bacterial Dressing for Low-Temperature Sterilization in Infected Lesions
Liu, T., Zhang, L., Xiong, C., Jiao, G., Tan, Y., Hou, J., Shi, H., Feng, J. X., & Zhang, X. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.4c01603 · Cited by 1
Synthesis and Biological Evaluation of Naproxen Derivatives as Novel NLRP3 Inhibitors
Li, Y., You, Z., Wong, V. K. W., Chen, M., Zhang, K., Liu, W., & Zhao, S. (2024) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c24-00465 · Cited by 1
The modeling of macrophage phenotypic states in diseases regulated by physical properties of extracellular matrix
Zhou, Y., & Wu, Y. (2025) · Nonlinear Dynamics · doi:10.1007/s11071-025-10866-1 · Cited by 1
Polyelectrolyte Multilayer Coatings As a Tunable Tool to Control Inflammatory Response to Biomaterials in Vitro
Rosahl, F., Segan, S., Jakobi, M., Arefaine, E., Pickarski, L., Strano, L., Gerlach, K., Krastev, R., Andreeva, T. D., Schneiderhan‐Marra, N., et al. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01021 · Cited by 3
Extracellular matrix and immune dysfunction: An overlooked relationship in idiopathic pulmonary fibrosis
Nyaupane, U., Johannson, K. A., Kelly, M. M., & Kai, F. (2025) · Experimental Lung Research · doi:10.1080/01902148.2025.2582970 · Cited by 1
Co-evolving biomaterials: Spatiotemporally programmable materials steering dynamic macrophage state transitions
Li, M., Feng, Z., Zeng, S., Jin, M., Chen, S., Yang, H., & Huang, Y. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.04.055 · Cited by 2
Advances in Macrophage Mechanoimmunology: Understanding the Role of Ultrasound Mechanical effect
Liang, X., Guo, Z., & Chen, Z. (2025) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2025.10.010 · Cited by 2
Mechanobiological regulation of T cells via transient viscoelastic microfluidic confinement
Asghari, M. H., Aramesh, M., Mathur, P., Meng, Y., Bernero, M., Viola Vogel, B., Stavrakis, S., & deMello, A. J. (2025) · Lab on a Chip · doi:10.1039/d5lc00833f · Cited by 1
Higher actin contractility and cargo-loaded clathrin pits create midplane-peaked apico-basal tension profiles in HeLa cells
Ghosh, T., Majhi, A., Kundu, A., Banerjee, A., & Sinha, B. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.103046 · Cited by 1
Oriented microstructures and HA/PSP modulation of PEEK implants synergistically promote muscle integration via Myogenesis, immunomodulation and angiogenesis
Su, Y., Chen, Y., Li, Z., Pan, Z., Jiang, L., Xu, X., Yang, C., Wu, J., Zhang, Y., Lin, K., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.172915 · Cited by 1
Hydrogel viscoelasticity regulates human monocyte-derived macrophage morphology and phenotype in 2D culture
Coser, C., di Bari, V., Ghaemmaghami, A. M., & Yang, J. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.04.032 · Cited by 2
Patterning bacterial nanocellulose at cell-size scale using UV laser technology to create immunomodulatory interfaces
Costa, L., Carvalho, A. F., Fernandes, A. J. S., Moura, J. P., Silva-Carvalho, R., Lebre, F., Gonçalves, C., Costa, F. M., & Gama, M. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.214948 · Cited by 1
Nuclear mechanotransduction: tools for mechanical perturbation and chromatin characterization
Soto, J., Origer, N., Wu, Y. N., Cardenas‐Benitez, B., Massad, R. N., Rahgoshay, D., Lee, A., Downing, T., & Li, S. (2026) · Nucleus · doi:10.1080/19491034.2026.2690847 · Cited by 1
Macrophage polarization state influences fusion and phenotype of human foreign body giant cells in vitro
Conner, T., de Kort, B. J., & Smits, A. I. P. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1832686 · Cited by 1
Immune-instructive materials and surfaces for medical applications
Fisher, L. E., & Ghaemmaghami, A. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821440-4.00008-6 · Cited by 1
The Biophysical Micro-Environment's Influence on Cell Fate Decisions During Macrophage Activation and Somatic Cell ReprogrammingPreprint
Reitz, Z. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2005.04877 · Cited by 1
MRTF May Be the Missing Link in a Multiscale Mechanobiology Approach toward Macrophage Dysfunction in SpacePreprint
An, R. (2022) · Preprints.org · doi:10.20944/preprints202207.0106.v1 · Cited by 1
MRTF May Be the Missing Link in a Multiscale Mechanobiology Approach toward Macrophage Dysfunction in SpacePreprint
An, R. (2022) · Preprints.org · doi:10.20944/preprints202207.0106.v2 · Cited by 1
Harnessing Mechanical Forces for Cancer TreatmentPreprint
Kumari, A., Veena, S., Luha, R., & Tijore, A. (2023) · Preprints.org · doi:10.20944/preprints202307.2038.v1
Magnetic nanocomplexes coupled with an external magnetic field modulate macrophage phenotype – a non-invasive strategy for bone regenerationPreprint
Kumar, H. S., Yi, Z., Tong, S., & Annamalai, R. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.02.556050 · Cited by 1
The Dual Roles of Lamin A/C in Mechanosensation to Compressive ForcePreprint
Groeger, S. E., Wang, Y., Ruf, S., & Wang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3586140/v1 · Cited by 1
Physical confinement and phagocytic uptake induce directional migrationPreprint
Paulson, S. G., Liu, S., & Rotty, J. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.13.653701 · Cited by 1
Matrix Stiffness Governs Fibroblast-Driven Immune Homeostasis in Gingival TissuesPreprint
Makkar, H., Tran, N., Chen, Y., Ko, K. I., Wells, R. G., & Vining, K. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683155 · Cited by 1
Inflammation Environment-Adaptive Patterned Surface for Spatiotemporal Immunomodulation of MacrophagesPreprint
Luo, Y., Yuan, P., Hu, S., Wang, H., Zhang, H., & Ma, L. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4097601
African Swine Fever Virus Innate Immune Escape and Adaptive Immune Evasion: A ReviewPreprint
Niu, S., Guo, Y., Wang, X., Wang, Z., Sun, L., Dai, H., & Peng, G. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4516720
Kynurenic acid and its analog SZR104 exhibit strong antiinflammatory effects and alter the intracelluladistribution and methylation patterns of H3 histones in immunochallenged microglia-enriched cultures of newborn rat brains
Lajkó, N. (2022) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.11369
Produção e caracterização de malhas poliméricas de policaprolactona com resveratrol para uso como biomaterial
Dias, F. J. D. N. (2021) · doi:10.47749/t/unicamp.2021.1234572
Induced Formation of Plasma Membrane Protrusions with Porous Materials as Instructive Surfaces
Aramesh, M., & Persson, C. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3834-7_3
Intricate Synergy of Mechanical and Biochemical Cues in the Transmigration of Cancer Cells Across the Endothelium
Mierke, C. T. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_237
WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelopePreprint
Amadio, R., Bracchetti, G., Alraies, Z., Piperno, G. M., Rodríguez, L. L., Maurin, M., Conti, M., Andolfi, L., Castiello, M. C., Ferrua, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.23.630061
In-House Manufacturing of 3D Culture Chips via Vacuum Thermoforming for Enhanced Imaging ApplicationsPreprint
Fomina, A., Tam, A., Lam, J., Wu, N. C., Li, N. T., & McGuigan, A. P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.640460
Advances in Biomaterial Mechanical Properties to Regulate Macrophage Polarization
贾, 恒. (2025) · Journal of Clinical Personalized Medicine · doi:10.12677/jcpm.2025.42244
Chemo-mechanotherapy of fibrosis: dynamic control of biological materials through tissue-architecture-dependent crosslink disruptionPreprint
Kong, W., Song, M., Peng, X., Bai, L., Zeng, J., Liang, K., Jin, Y., Wang, J., Wang, X., Huang, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.01.673308
Dual-Engineered Hydrogels from Shared Precursors: Injectable Conformability and Janus Asymmetric Adhesion for Emergency Hemostasis and Accelerated Wound Healing
Xie, Y., Xu, G., & Zhong, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c22258
Additional file 4 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752243
Additional file 3 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752240
Additional file 5 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752246
Additional file 1 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26341944
Additional file 7 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752252
Additional file 8 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752255
Additional file 2 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26341989
Additional file 9 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752258
Additional file 1 of Nanotube patterning reduces macrophage inflammatory response via nuclear mechanotransduction
Fu, Y., Zheng, J., Chen, T., Xu, X., Wang, X., Ren, M., Wu, Y., Wu, T., Li, Y., Zhang, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23714109
Additional file 6 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752249
Zoledronic acid/cisplatin-loaded cucurbit[7]uril-modified upconversion nanoformulations drive tumor-associated macrophage polarization and potentiate the efficacy of cancer immunotherapy
Ge, Y., Li, P., Zhang, J., Wang, R., Zhang, R., Xu, H., Hao, Z., & Zhang, Y. (2026) · Journal of Biomaterials Applications · doi:10.1177/08853282261422838
A customizable, low-cost 3D-printed device for live cell confinement imaging
Richman, H., Ou, J., Khera, M., & Yu, Y. (2026) · Lab on a Chip · doi:10.1039/d5lc01146a
Nanofunctionalised Scaffolds with Hierarchical Porosity
Omidvari, E. (2024) · doi:10.70675/ec058061zd152z4878zb94eze28a454dae6d
Dynamic mechanical three-way crosstalk at the interfaces of cancer cells, immune cells, like macrophages and stromal cells
Mierke, C. T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30048-6.00002-4
Understanding the osteoinductivity of calcium phosphate ceramics: From material factors to biological mechanisms
Xu, T., Zhuang, J., Lu, J., Xu, S., Zeb, S., Ren, Y., Chen, M., Yuan, C., & Duan, R. (2026) · Ceramics International · doi:10.1016/j.ceramint.2026.05.162
Targeting the macrophage mechanosensing regulator CKAP4 accelerates the inflammatory-to-proliferative transition in wound healing
Wang, H., Liu, W., Cheng, J., Wang, Y., Wang, W., Liu, T., Liang, Y., He, X., Zhao, Y., Xu, F., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117395
Mechano-reprogramming of tumor-associated macrophages by engineering nanogel stiffness for suppression of tumor development
Lin, H., Li, Z. L., Hua, A., Wu, S., Zhao, Q., Li, S., Zhang, S., Wang, X., Li, J., Deng, Q., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04793-5
Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation
Kondo, T., Yamada, M., Ambo, S., & Egusa, H. (2026) · International Journal of Implant Dentistry · doi:10.1186/s40729-026-00703-4
Microgel‐Based Immunomodulatory Biomaterials for Regulating Macrophage Polarization
Tuftee, C., & Rizwan, M. (2026) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.70132
Cell-Type-Tailored Hydrogels for Adoptive Cell Therapy in Cancer
Shin, J. H., Song, Y., & Park, J. (2026) · Gels · doi:10.3390/gels12080678
Real-Time Scanning Ion Conductance Microscopy Reveals MARCKS-Driven Morphological Remodeling and Nanomechanical Softening during LPS-Induced Macrophage Polarization
Wang, D., Yamase, R., Park, K., Nishikawa, H., Shevchuk, A., Coll, R. C., Korchev, Y. E., Wang, W., & Zhang, Y. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c01115
Adhesome-targeting shRNA modulates inferred cell fate trajectories and cell-cell communication during iPSC reprogramming
Phan, T. A. Q., Origer, N., Aleman, E., Ren, K., Shao, H., He, C., Jin, S., Nie, Q. H., & Downing, T. L. (2026) · Mechanobiology · doi:10.1177/29780241261474765
Geometric mechanogenomics: engineering boundary conditions for deterministic cell fate control
Taghizadeh, M., Taghizadeh, A. A., & Kim, H. S. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1922536
Nuclear mechanobiology: a brief history and five unresolved questions
Lammerding, J., Eeftens, J. M., Gundersen, G. G., King, M. C., Lele, T. P., Li, S., Luxton, G. W. G., Medalia, O., Piel, M., Roca‐Cusachs, P., et al. (2026) · Nucleus · doi:10.1080/19491034.2026.2709894
Pore size of gelatin/hyaluronic acid supramolecular hydrogel modulates the immune functions of bone marrow-derived immature dendritic cells
Zhang, H., Wu, C., Teng, L., Sun, X., Xu, P., Zeng, X., Long, J., & Zeng, Z. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154736

Authors: Jain, N., & Vogel, V.
Affiliations: ETH Zurich (CH)
Corresponding author: Jain, Nikhil
ORCID: Jain, Nikhil
Vogel, Viola
Venue: Nature Materials
Publisher: Springer Science and Business Media LLC
Published: 2018-10-22
Volume: 17
Issue: 12
Pages: 1134-1144
ISSN: 1476-1122 (ISSN-L)
1476-4660
DOI: 10.1038/s41563-018-0190-6
PMC: PMC6615903
OpenAlex: W2897232908
Semantic Scholar: 1ac0e557d3aa67ca54c6e9b0d8a6b4d14e856299
Cited by: 271
References: 65
Citations by year: 2026: 27 · 2025: 39 · 2024: 45 · 2023: 38 · 2022: 47 · 2021: 42 · 2020: 20 · 2019: 12 · 2018: 1
FWCI: 10.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Materials (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (156931)
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (U54DK106857)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: macrophage inflammation, spatial confinement, micropatterning, cell crowding, lipopolysaccharide, mechanotransduction, chromatin condensation, epigenetic regulation, HDAC3, H3K36 dimethylation, actin polymerization, MRTF-A, SRF, inflammatory cytokines, phagocytosis, mechanobiology, TLR4 signaling
MeSH terms: RAW 264.7 Cells, Histone Deacetylase 3, Actins, Animals, Histone Deacetylases, Inflammation, Lipopolysaccharides, Macrophages, Transcription, Genetic, Signal Transduction, Cytokines, Epigenesis, Genetic, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Spatial confinement downsizes the inflammatory response of macrophages

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks