The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Thermoplastic moulding of regenerated silk
Open accessAbstract
Early insights into the unique structure and properties of native silk suggested that β-sheet nanocrystallites in silk would degrade prior to melting when subjected to thermal processing. Since then, canonical approaches for fabricating silk-based materials typically involve solution-derived processing methods, which have inherent limitations with respect to silk protein solubility and stability in solution, and time and cost efficiency. Here we report a thermal processing method for the direct solid-state moulding of regenerated silk into bulk ‘parts’ or devices with tunable mechanical properties. At elevated temperature and pressure, regenerated amorphous silk nanomaterials with ultralow β-sheet content undergo thermal fusion via molecular rearrangement and self-assembly assisted by bound water to form a robust bulk material that retains biocompatibility, degradability and machinability. This technique reverses presumptions about the limitations of direct thermal processing of silk into a wide range of new material formats and composite materials with tailored properties and functionalities. Biocompatible and degradable silk materials with programmable mechanical properties can be directly obtained from regenerated amorphous silk using thermal moulding.
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Cites
Bioinspired structural materials
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Self-citationStructures, mechanical properties and applications of silk fibroin materials
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Cited by
Hierarchically structured bioinspired nanocomposites
Nepal, D., Kang, S., Adstedt, K. M., Kanhaiya, K., Bockstaller, M. R., Brinson, L. C., Buehler, M. J., Coveney, P. V., Dayal, K., El-Awady, J. A., et al. (2023) · Nature Materials · doi:10.1038/s41563-022-01384-1 · Cited by 594
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Hu, Z., Liang, Y., Fan, S., Niu, Q., Geng, J., Huang, Q., Hsiao, B. S., Chen, H., Yao, X., & Zhang, Y. (2024) · Advanced Materials · doi:10.1002/adma.202410007 · Cited by 55
Metadata
- Authors
- Guo, C., Li, C., Vu, H. V., Hanna, P., Lechtig, A., Qiu, Y., Mu, X., Ling, S., Nazarian, A., Lin, S. J., & Kaplan, D. L.
- Venue
- Nature Materials
- Published
- 2019-12-16
- Volume
- 19
- Issue
- 1
- Pages
- 102-108
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2996620253
- Cited by
- 268
- References
- 47
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Guo, C., Li, C., Vu, H. V., Hanna, P., Lechtig, A., Qiu, Y., Mu, X., Ling, S., Nazarian, A., Lin, S. J., & Kaplan, D. L. (2020). Thermoplastic moulding of regenerated silk. Nature Materials. https://doi.org/10.1038/s41563-019-0560-8
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