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Cited by 3,066

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Materials fabrication from Bombyx mori silk fibroin

Open access
Rockwood, Danielle N, Preda, Rucsanda C, Yücel, Tuna, Wang, Xiaoqin, Lovett, Michael L, Kaplan, David L·2011·Nature Protocols
DOI 10.1038/nprot.2011.379
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Abstract

Silk fibroin, derived from Bombyx mori cocoons, is a widely used and studied protein polymer for biomaterial applications. Silk fibroin has remarkable mechanical properties when formed into different materials, demonstrates biocompatibility, has controllable degradation rates from hours to years and can be chemically modified to alter surface properties or to immobilize growth factors. A variety of aqueous or organic solvent-processing methods can be used to generate silk biomaterials for a range of applications. In this protocol, we include methods to extract silk from B. mori cocoons to fabricate hydrogels, tubes, sponges, composites, fibers, microspheres and thin films. These materials can be used directly as biomaterials for implants, as scaffolding in tissue engineering and in vitro disease models, as well as for drug delivery.

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Research works printed but not linked: 66

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Metadata

Authors
Rockwood, D. N., Preda, R. C., Yücel, T., Wang, X., Lovett, M. L., & Kaplan, D. L.
Venue
Nature Protocols
Publisher
Springer Science and Business Media LLC
Published
2011-09-22
Volume
6
Issue
10
Pages
1612-1631
ISSN
  • 1750-2799 (ISSN-L)
  • 1754-2189
DOI
10.1038/nprot.2011.379
OpenAlex
W2060077653
Cited by
3,066
References
5
FWCI
24.07
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Materials fabrication from Bombyx mori silk fibroin. https://app.cochat.ai/papers/10.1038/nprot.2011.379
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Rockwood, D. N., Preda, R. C., Yücel, T., Wang, X., Lovett, M. L., & Kaplan, D. L. (2011). Materials fabrication from Bombyx mori silk fibroin. Nature Protocols. https://doi.org/10.1038/nprot.2011.379

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