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Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity
Abstract
Emerging evidence implicates a role of the gut microbiota in colorectal cancer (CRC). Peptostreptococcus anaerobius (P. anaerobius) is an anaerobic bacterium selectively enriched in the faecal and mucosal microbiota from patients with CRC, but its causative role and molecular mechanism in promoting tumorigenesis remain unestablished. We demonstrate that P. anaerobius adheres to the CRC mucosa and accelerates CRC development in Apc Min/+ mice. In vitro assays and transmission electron microscopy revealed that P. anaerobius selectively adheres to CRC cell lines (HT-29 and Caco-2) compared to normal colonic epithelial cells (NCM460). We identified a P. anaerobius surface protein, putative cell wall binding repeat 2 (PCWBR2), which directly interacts with colonic cell lines via α 2/β 1 integrin, a receptor frequently overexpressed in human CRC tumours and cell lines. Interaction between PCWBR2 and integrin α 2/β 1 induces the activation of the PI3K-Akt pathway in CRC cells via phospho-focal adhesion kinase, leading to increased cell proliferation and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. NF-κB in turn triggers a pro-inflammatory response as indicated by increased levels of cytokines, such as interleukin-10 and interferon-γ in the tumours of P. anaerobius-treated Apc Min/+ mice. Analyses of tumour-infiltrating immune cell populations in P. anaerobius-treated Apc Min/+ mice revealed significant expansion of myeloid-derived suppressor cells, tumour-associated macrophages and granulocytic tumour-associated neutrophils, which are associated with chronic inflammation and tumour progression. Blockade of integrin α 2/β 1 by RGDS peptide, small interfering RNA or antibodies all impair P. anaerobius attachment and abolish P. anaerobius-mediated oncogenic response in vitro and in vivo. Collectively, we show that P. anaerobius drives CRC via a PCWBR2-integrin α 2/β 1-PI3K-Akt-NF-κB signalling axis and identify the PCWBR2-integrin α 2/β 1 axis as a potential therapeutic target for CRC.
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“Some members of this signature, such as F. nucleatum and P. anaerobius, have been shown to promote colorectal carcinogenesis and modulate tumour immunity74,75”
From Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy (2023) · cites this paper as [75]
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“anaerobius was not only enriched in the faecal and mucosal microbiota of CRC patients but also promoted the carcinogenesis in spontaneous CRC model [9, 43].”
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“105 Concurrently, P. anaer-obius has been shown to significantly increase the population of immunosuppressive cells via the NF-kB signaling pathway, encompassing myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and granulocytic tumor-associated neutrophils (TANs) in…”
InfluentialThe role of intestinal flora on tumor immunotherapy: recent progress and treatment implications
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Metadata
- Authors
- Long, X., Wong, C. C., Tong, L., Chu, E. S. H., Ho Szeto, C., Go, M. Y. Y., Coker, O. O., Chan, A. W. H., Chan, F. K. L., Sung, J. J. Y., & Yu, J.
- Affiliations
- Chinese University of Hong Kong (HK)
- Corresponding author
- Yu, Jun
- ORCID
- Venue
- Nature Microbiology
- Published
- 2019-09-09
- Volume
- 4
- Issue
- 12
- Pages
- 2319-2330
- ISSN
- 2058-5276 (ISSN-L)
- OpenAlex
- W2972734154
- Cited by
- 557
- References
- 34
- Citations by year
- 2026: 88 · 2025: 101 · 2024: 87 · 2023: 112 · 2022: 72 · 2021: 64 · 2020: 31
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- Peptostreptococcus anaerobius, colorectal cancer, colorectal carcinogenesis, gut microbiota, bacterial adhesion, PI3K/Akt signaling, NF-κB, focal adhesion kinase, tumour immunity, myeloid-derived suppressor cells, tumour-associated macrophages, tumor-associated neutrophils, chronic inflammation, ApcMin/+ mice, RGDS peptide, therapeutic target, tumor microenvironment
- MeSH terms
- Animals, Biotin, Cell Survival, Colon, Disease Models, Animal, Humans, Male, Mice, Inbred C57BL, Peptostreptococcus, Colorectal Neoplasms, Signal Transduction, Cytokines, NF-kappa B, Caco-2 Cells, HT29 Cells, Phosphatidylinositol 3-Kinases, Gene Expression Profiling, Integrin alpha2beta1, Cell Proliferation, Mice, Focal Adhesion Protein-Tyrosine Kinases, Gene Knockdown Techniques, Carcinogenesis
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