The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles
Open accessAbstract
Deposition of complement factors (opsonization) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood. We previously demonstrated that opsonization of superparamagnetic iron oxide (SPIO) nanoworms with the third complement protein (C3) was dependent on the biomolecule corona of the nanoparticles. Here we show that natural antibodies play a critical role in C3 opsonization of SPIO nanoworms and a range of clinically approved nanopharmaceuticals. The dependency of C3 opsonization on immunoglobulin binding is almost universal and is observed regardless of the complement activation pathway. Only a few surface-bound immunoglobulin molecules are needed to trigger complement activation and opsonization. Although the total amount of plasma proteins adsorbed on nanoparticles does not determine C3 deposition efficiency, the biomolecule corona per se enhances immunoglobulin binding to all nanoparticle types. We therefore show that natural antibodies represent a link between biomolecule corona and C3 opsonization, and may determine individual complement responses to nanomedicines.Immunoglobulins mediate deposition of the third complement protein (C3) on the biomolecule corona of nanoparticles, promoting complement activation.
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Cites
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Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
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Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials
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Cited by
Chen, S., Zhong, Y., Fan, W., Xiang, J., Wang, G., Zhou, Q., Wang, J., Geng, Y., Sun, R., Zhang, Z., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00701-4 · Cited by 325
Self-citationZhang, D., Chen, Q., Shi, C., Chen, M., Ma, K., Wan, J., & Liu, R. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202007226 · Cited by 303
Nanoparticle protein corona: from structure and function to therapeutic targeting
Bashiri, G., Padilla, M. S., Swingle, K. L., Shepherd, S. J., Mitchell, M. J., & Wang, K. (2023) · Lab on a Chip · doi:10.1039/d2lc00799a · Cited by 296
Domesticating the foreign body response: recent advances and applications
Veiseh, O., & Vegas, A. J. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.08.010 · Cited by 245
Padín-González, E., Lancaster, P., Bottini, M., Gasco, P., Tran, L., Fadeel, B., Wilkins, T., & Monopoli, M. P. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.882363 · Cited by 166
Metadata
- Authors
- Vu, V. P., Gifford, G. B., Chen, F., Benasutti, H., Wang, G., Groman, E. V., Scheinman, R., Saba, L., Moghimi, S. M., & Simberg, D.
- Venue
- Nature Nanotechnology
- Published
- 2019-01-14
- Volume
- 14
- Issue
- 3
- Pages
- 260-268
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2907835634
- Cited by
- 309
- References
- 6
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Vu, V. P., Gifford, G. B., Chen, F., Benasutti, H., Wang, G., Groman, E. V., Scheinman, R., Saba, L., Moghimi, S. M., & Simberg, D. (2019). Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles. Nature Nanotechnology. https://doi.org/10.1038/s41565-018-0344-3
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