Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials
Abstract
While plasma proteins can influence the physicochemical properties of nanoparticles, the adsorption of protein to the surface of nanomaterials can also alter the structure and function of the protein. Here, we show that plasma proteins form a hard corona around synthetic layered silicate nanoparticles (LSN) and that one of the principle proteins is serum albumin. The protein corona was required for recognition of the nanoparticles by scavenger receptors, a major receptor family associated with the mononuclear phagocyte system (MPS). Albumin alone could direct nanoparticle uptake by human macrophages, which involved class A but not class B scavenger receptors. Upon binding to LSN, albumin unfolded to reveal a cryptic epitope that could also be exposed by heat denaturation. This work provides an understanding of how albumin, and possibly other proteins, can promote nanomaterial recognition by the MPS without albumin requiring chemical modification for scavenger receptor recognition. These findings also demonstrate an additional function for albumin in vivo.
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When non-covalently adsorbed on nanoparticles with precisely designed supramolecular interaction, specific domains of proteins can interact with the nanoparticle surface in thermodynamically favorable manners, leading to colloidal stabilization and dysopsonization of particles in a physiological environment.
“When non-covalently adsorbed on nanoparticles with precisely designed supramolecular interaction, specific domains of proteins can interact with the surface of nanoparticles in thermodynamically favorable manners, leading to the colloidal stabilization and dysopsonization of particles in a physiological environment35,36.”
From Cloaking nanoparticles with protein corona shield for targeted drug delivery. (2018) · cites this paper as [36]
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- Authors
- Mortimer, G. M., Butcher, N. J., Musumeci, A. W., Deng, Z. J., Martin, D. J., & Minchin, R. F.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Minchin, Rodney F.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-27
- Volume
- 8
- Issue
- 4
- Pages
- 3357-3366
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2046550789
- Cited by
- 154
- References
- 61
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 17 · 2020: 14 · 2019: 12 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 9 · 2014: 9
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (569694)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- serum albumin, protein corona, reticuloendothelial system, scavenger receptors, scavenger receptor A, nanoparticle clearance, cryptic epitopes, protein unfolding, macrophage uptake, nanoparticle-protein interactions
- MeSH terms
- Epitopes, Biological Transport, Cell Line, Humans, Macrophages, Models, Molecular, Protein Conformation, Serum Albumin, Silicates, Nanoparticles
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