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Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity
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“The expression of IL-12 activates immune cells within the tumor microenvironment, strengthening the anti-tumor immune response and fostering long-lasting tumor-specific immune memory [85].”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [85]
In the citing paper
“Furthermore, encapsulating IL-12 mRNA in exosomes for inhalable delivery allows for targeted treatment of lung cancer cells while minimizing systemic side effects.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [85]
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Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
Wolchok, J. D., Chiarion-Sileni, V., Gonzalez, R., Rutkowski, P., Grob, J.-J., Cowey, C. L., Lao, C. D., Wagstaff, J., Schadendorf, D., Ferrucci, P. F., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1709684 · Cited by 5,357 · cited 1×
“Immune checkpoint blockade therapies hold promise for inducing tumour regression 1,2 but often fall short due to the immunosuppressive tumour microenvironment (TME) 3,4 .”
RNA delivery by extracellular vesicles in mammalian cells and its applications
O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811
Nonviral delivery of self-amplifying RNA vaccines
Geall, A. J., Verma, A., Otten, G. R., Shaw, C. A., Hekele, A., Banerjee, K., Cu, Y., Beard, C. W., Brito, L. A., Krucker, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209367109 · Cited by 675 · cited 1×
“Inhalation may not suit patients with respiratory complications, and the transient nature of mRNA prompts the exploration of payloads such as self-amplifying RNA 14,54 for persistent cytokine expression.”
Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth
Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337
Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K. D., Dong, Y., Irvine, D. J., & Weiss, R. (2020) · Nature Cancer · doi:10.1038/s43018-020-0095-6 · Cited by 233
Inhalable dry powder mRNA vaccines based on extracellular vesicles
Popowski, K. D., Moatti, A., Scull, G., Silkstone, D., Lutz, H., López de Juan Abad, B., George, A., Belcher, E., Zhu, D., Mei, X., et al. (2022) · Matter · doi:10.1016/j.matt.2022.06.012 · Cited by 218
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Cited by
Sorted by citations
Emerging role of exosomes in cancer therapy: progress and challenges
Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 297
Metadata
- Authors
- Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K.
- Venue
- Nature Nanotechnology
- Published
- 2024-01-11
- Volume
- 19
- Issue
- 4
- Pages
- 565-575
- ISSN
- 1748-3387
- 1748-3395
- PMC
- PMC12930425
- Cited by
- 277
- References
- 6
- Language
- en
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