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ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis

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A risk-based approach for cell line development, manufacturing and characterization of genetically engineered, induced pluripotent stem cell–derived allogeneic cell therapies

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Interleukin-12 in multimodal tumor therapies for induction of anti-tumor immunity

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Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses

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Genomic and transcriptomic landscape of human gastrointestinal stromal tumors

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The role of SETD1A and SETD1B in development and disease

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Prioritizing Cancer Genes Based on an Improved Random Walk Method

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Deregulated Immune Pathway Associated with Palbociclib Resistance in Preclinical Breast Cancer Models: Integrative Genomics and Transcriptomics

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Cell-cell fusions and cell-in-cell phenomena in healthy cells and cancer: Lessons from protists and invertebrates

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Contiguous erosion of the inactive X in human pluripotency concludes with global DNA hypomethylation

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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown

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ImmReg: the regulon atlas of immune-related pathways across cancer types

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Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach

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HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy

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DGMP: Identifying Cancer Driver Genes by Jointing DGCN and MLP from Multi-Omics Genomic Data

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A two-phase gene selection method using anomaly detection and genetic algorithm for microarray data

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Identifying the tissues-of-origin of circulating cell-free DNAs is a promising way in noninvasive diagnostics

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Rare germline structural variants increase risk for pediatric solid tumors

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A first-in-human clinical study of an allogenic iPSC-derived corneal endothelial cell substitute transplantation for bullous keratopathy

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Finding the Right Way to Target EGFR in Glioblastomas; Lessons from Lung Adenocarcinomas

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PHLPPing the balance: restoration of protein kinase C in cancer

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Actionable data for precision oncology: Framing trustworthy evidence for exploratory research and clinical diagnostics

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The landscape and driver potential of site-specific hotspots across cancer genomes

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Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes

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Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content

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Dynamic Interplay between Structural Variations and 3D Genome Organization in Pancreatic Cancer

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Starfish infers signatures of complex genomic rearrangements across human cancers

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Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks

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Evaluating the Utility of ctDNA in Detecting Residual Cancer and Predicting Recurrence in Patients with Serous Ovarian Cancer

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The anaphase‐promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer

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A synergetic effect of BARD1 mutations on tumorigenesis

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Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer

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Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound

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Mass Spectrometry Imaging Spatial Tissue Analysis toward Personalized Medicine

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Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas

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Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma

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Tailor-made molecular imprints for biological event intervention

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SpliceVarDB: A comprehensive database of experimentally validated human splicing variants

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Mutational and co-mutational landscape of early onset colorectal cancer

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Investigating the origins of the mutational signatures in cancer

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Mutations in transmembrane proteins: diseases, evolutionary insights, prediction and comparison with globular proteins

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Identifying modules of cooperating cancer drivers

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Advancing clinical genomics and precision medicine with GVViZ: FAIR bioinformatics platform for variable gene-disease annotation, visualization, and expression analysis

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Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models

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Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization

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Profiling the Mutational Landscape in Known Driver Genes and Novel Genes in African American Non–Small Cell Lung Cancer Patients

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Ontology-based prediction of cancer driver genes

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Mutational and transcriptomic landscapes of a rare human prostate basal cell carcinoma

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Dynamic incorporation of prior knowledge from multiple domains in biomarker discovery

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Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2 , TP53 , and CBL mutations

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Oncogene aberrations drive medulloblastoma progression, not initiation

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Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

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Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration

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Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway

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The tumor suppression theory of aging

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Chromatin Remodeler Smarca5 Is Required for Cancer-Related Processes of Primary Cell Fitness and Immortalization

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The comprehensive expression and functional analysis of m6A modification “readers” in hepatocellular carcinoma

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Heterogeneity of the cancer cell line metabolic landscape

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Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis

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Impact of mouse contamination in genomic profiling of patient-derived models and best practice for robust analysis

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Whole-exome Sequencing Reveals New Potential Susceptibility Genes for Japanese Familial Pancreatic Cancer

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Knowledge bases and software support for variant interpretation in precision oncology

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Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer

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Prediction and analysis of tumor infiltrating lymphocytes across 28 cancers by TILScout using deep learning

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Putatively cancer-specific exon–exon junctions are shared across patients and present in developmental and other non-cancer cells

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ADRML: anticancer drug response prediction using manifold learning

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Recurrent Somatic Chromosomal Abnormalities in Relapsed Extraocular Retinoblastoma

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Performance evaluation of differential splicing analysis methods and splicing analytics platform construction

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Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data

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Expression-based prediction of human essential genes and candidate lncRNAs in cancer cells

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KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma

Saglam, O., Tang, Z., Tang, G., Medeiros, L. J., & Törüner, G. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238477 · Cited by 24

Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring

Kuzmin, E., Baker, T. M., Lesluyes, T., Monlong, J., Abe, K. T., Coelho, P. P., Schwartz, M., Del Corpo, J., Zou, D., Morin, G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113988 · Cited by 20

HotSpotAnnotations—a database for hotspot mutations and annotations in cancer

Treviño, V. (2020) · Database · doi:10.1093/database/baaa025 · Cited by 22

Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes

Fatima, I., Chen, G., Botchkareva, N. V., Sharov, A. A., Thornton, D., Wilkinson, H. N., Hardman, M. J., Grützkau, A., de Magalhães, J. P., Seluanov, A., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.04.028 · Cited by 24

The telomere maintenance mechanism spectrum and its dynamics in gliomas

Kim, S., Chowdhury, T., Yu, H. J., Kahng, J. Y., Lee, C. E., Choi, S. A., Kim, K., Kang, H. J., Lee, J. H., Lee, S., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01095-x · Cited by 21

Pan-cancer clinical impact of latent drivers from double mutations

Yavuz, B. R., Tsai, C., Nussinov, R., & Tunçbağ, N. (2023) · Communications Biology · doi:10.1038/s42003-023-04519-5 · Cited by 25

Caenorhabditis elegansfor research on cancer hallmarks

Cerón, J. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050079 · Cited by 24

Tumour mutations in long noncoding RNAs enhance cell fitness

Esposito, R., Lanzós, A., Uroda, T., Ramnarayanan, S., Büchi, I., Polidori, T., Guillen-Ramirez, H., Mihaljevic, A., Merlin, B. M., Mela, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39160-7 · Cited by 27

Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1

Li, L., Cui, Y., Shen, J., Dobson, H. E., & Sun, G. (2019) · Leukemia Research · doi:10.1016/j.leukres.2019.01.006 · Cited by 22

Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets in oncology

Bazaga, A., Leggate, D., & Weisser, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-67846-1 · Cited by 23

Immunopeptidogenomics: Harnessing RNA-Seq to Illuminate the Dark Immunopeptidome

Scull, K. E., Pandey, K., Ramarathinam, S. H., & Purcell, A. W. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100143 · Cited by 22

PTEN in Regulating Hematopoiesis and Leukemogenesis

Wu, Y., Zhu, H., & Wu, H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036244 · Cited by 22

Generalizable and scalable protein stability prediction with rewired protein generative models

Li, Z., & Luo, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-67609-4 · Cited by 24

Gα15 in early onset of pancreatic ductal adenocarcinoma

Innamorati, G., Wilkie, T. M., Malpeli, G., Paiella, S., Grasso, S., Rusev, B. C., Leone, B. E., Valenti, M. T., Carbonare, L. D., Cheri, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94150-3 · Cited by 21

Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib

Lee, C.-J., Schöffski, P., Modave, E., van Wezel, T., Boeckx, B., Sufliarsky, J., Gelderblom, H. A. J., Blay, J., Debiec-Rychter, M., Sciot, R., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1165 · Cited by 21

Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer

Namba, S., Ueno, T., Kojima, S., Kobayashi, K., Kawase, K., Tanaka, Y., Inoue, S., Kishigami, F., Kawashima, S., Maeda, N., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02833-4 · Cited by 21

Intratumoral IL-1R1 expression delineates a distinctive molecular subset with therapeutic resistance in patients with gastric cancer

Zhang, P., Gu, Y., Fang, H., Cao, Y., Wang, J., Liu, H., Zhang, H., He, L., He, H., Li, R., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004047 · Cited by 25

Detection of Oncogenic and Clinically Actionable Mutations in Cancer Genomes Critically Depends on Variant Calling Tools

García-Prieto, C. A., Martínez-Jiménez, F., Valencia, A., & Porta‐Pardo, E. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btac306 · Cited by 19

“HLA-C: evolution, epigenetics, and pathological implications in the major histocompatibility complex”

Velasteguí, E., Vera, E., Berghe, W. V., Muñoz, M. S., & Orellana‐Manzano, A. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1206034 · Cited by 23

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations

Besedina, E. G., & Supek, F. (2024) · Nature Communications · doi:10.1038/s41467-024-50552-1 · Cited by 21

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Nair, N. U., Schäffer, A. A., Gertz, E. M., Cheng, K., Zerbib, J., Sahu, A. D., Leor, G., Shulman, E. D., Aldape, K., Ben‐David, U., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-1366 · Cited by 21

Abstract 2469: The COSMIC Cancer Gene Census - a comprehensive study of all mutated cancer-driving genes

Sońdka, Z., Speedy, H. E., Bamford, S., Cole, C. G., Ward, S. A., & Forbes, S. A. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-2469 · Cited by 1

Abstract 2599: COSMIC Cancer Gene Census: expert descriptions across genes in oncogenesis

Sońdka, Z., Bamford, S., Cole, C. G., Dawson, E., Ponting, L., Stefancsik, R., Ward, S. A., Tate, J. G., Campbell, P. J., & Forbes, S. A. (2017) · Cancer Research · doi:10.1158/1538-7445.am2017-2599

COSMIC: the Catalogue Of Somatic Mutations In Cancer

Tate, J. G., Bamford, S., Jubb, H. C., Sondka, Z., Beare, D. M., Bindal, N., Boutselakis, H., Cole, C. G., Creatore, C., Dawson, E., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1015 · Cited by 4,867

Abstract 5285: COSMIC: comprehensively exploring oncogenomics

Forbes, S. A., Bindal, N., Beare, D. M., Bamford, S., Cole, C. G., Ward, S. A., Leung, K., Kok, C. Y., Jia, M., De, T., et al. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-5285 · Cited by 1

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screensPreprint

Repana, D., Nulsen, J., Dreßler, L., Bortolomeazzi, M., Venkata, S. K., Tourna, A., Yakovleva, A., Palmieri, T., & Ciccarelli, F. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/389858 · Cited by 38