The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
Liquid–liquid phase separation drives cellular function and dysfunction in cancer
Open accessAbstract
Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical pathways that have escaped the regulatory bounds of normal homeostatic balance. This balance is maintained through precise spatiotemporal regulation of these pathways. The formation of biomolecular condensates via liquid–liquid phase separation (LLPS) has recently emerged as a widespread mechanism underlying the spatiotemporal coordination of biological activities in cells. Biomolecular condensates are widely observed to directly regulate key cellular processes involved in cancer cell pathology, and the dysregulation of LLPS is increasingly implicated as a previously hidden driver of oncogenic activity. In this Perspective, we discuss how LLPS shapes the biochemical landscape of cancer cells. Liquid–liquid phase separation (LLPS) has been revealed as a widespread mechanism underlying the spatiotemporal coordination of biological activities in cells. This Perspective discusses how LLPS shapes the biochemical landscape of cancer cells, providing insight into emerging findings of dysregulated LLPS promoting cancer pathology.
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Cited by
Bercier, P., Wang, Q. Q., Zang, N., Zhang, J., Yang, C., Maimaitiyiming, Y., Abou-Ghali, M., Berthier, C., Wu, C., Niwa-Kawakita, M., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0453 · Cited by 45
Self-citationLiquid-liquid phase separation in Alzheimer’s disease
Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33
Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription
Iannucci, L. F., D’Erchia, A. M., Picardi, E., Bettio, D., Conca, F., Surdo, N. C., Di Benedetto, G., Musso, D., Arrigoni, C., Lolicato, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41088-x · Cited by 19
Metadata
- Authors
- Mehta, S., & Zhang, J.
- Venue
- Nature Reviews Cancer
- Published
- 2022-02-11
- Volume
- 22
- Issue
- 4
- Pages
- 239-252
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W4212769969
- Cited by
- 437
- References
- 175
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
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