Cited by 812Cardiovascular Disease and AdiposityCardiac Fibrosis and RemodelingCardiac Imaging and Diagnostics

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Epicardial adipose tissue in contemporary cardiology

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Iacobellis, Gianluca·2022·Nature Reviews Cardiology

DOI 10.1038/s41569-022-00679-9PMC PMC8926097

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Abstract

Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and unobstructed proximity to the heart and has a transcriptome and secretome very different from that of other fat depots. EAT has physiological and pathological properties that vary depending on its location. It can be highly protective for the adjacent myocardium through dynamic brown fat-like thermogenic function and harmful via paracrine or vasocrine secretion of pro-inflammatory and profibrotic cytokines. EAT is a modifiable risk factor that can be assessed with traditional and novel imaging techniques. Coronary and left atrial EAT are involved in the pathogenesis of coronary artery disease and atrial fibrillation, respectively, and it also contributes to the development and progression of heart failure. In addition, EAT might have a role in coronavirus disease 2019 (COVID-19)-related cardiac syndrome. EAT is a reliable potential therapeutic target for drugs with cardiovascular benefits such as glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter 2 inhibitors. This Review provides a comprehensive and up-to-date overview of the role of EAT in cardiovascular disease and highlights the translational nature of EAT research and its applications in contemporary cardiology.

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Additional file 4 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
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Additional file 13 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
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Additional file 12 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712674
Additional file 8 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
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Additional file 22 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712704
Additional file 10 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712668
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Additional file 5 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712653
Additional file 7 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712659
Additional file 10 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
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Additional file 3 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712647
Additional file 1 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737143
Additional file 12 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
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Additional file 14 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712680
Additional file 1 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712641
Additional file 11 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A. M., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737173
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Additional file 3 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737149
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Additional file 8 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737164
Additional file 9 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737167
Additional file 15 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712683
Additional file 18 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712692
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Additional file 2 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712644
Additional file 21 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712701
Additional file 9 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712665
Additional file 17 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712689
Additional file 2 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737146
Additional file 11 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712671
Additional file 19 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712695
Additional file 7 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737161
Additional file 1 of Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes
Cinti, F., Leccisotti, L., Sorice, G. P., Capece, U., D’Amario, D., Lorusso, M., Gugliandolo, S., Morciano, C., Guarneri, A., Guzzardi, M. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26656495
Additional file 20 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712698
Additional file 5 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737155
Additional file 16 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712686
Additional file 6 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712656
Additional file 23 of Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Ahmad, I., Gupta, S., Faulkner, P., Mullens, D. A., Thomas, M., Sytha, S. P., Ivanov, I. V., Cai, J. J., Heaps, C. L., & Newell‐Fugate, A. E. (2024) · Figshare · doi:10.6084/m9.figshare.26712707
Additional file 2 of Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes
Cinti, F., Leccisotti, L., Sorice, G. P., Capece, U., D’Amario, D., Lorusso, M., Gugliandolo, S., Morciano, C., Guarneri, A., Guzzardi, M. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26656498
Additional file 13 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737179
Additional file 6 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Ryk, A., Marcinkiewicz, A., Chrzanowski, J., Michalak, A., Dróźdż, I., Burzyński, J., Krejca, M., & Fendler, W. (2024) · Figshare · doi:10.6084/m9.figshare.26737158
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Authors: Iacobellis, G.
Affiliations: University of Miami (US)
Corresponding author: Iacobellis, Gianluca
ORCID: Iacobellis, Gianluca
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2022-03-16
Volume: 19
Issue: 9
Pages: 593-606
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/s41569-022-00679-9
PMC: PMC8926097
OpenAlex: W4220961850
Cited by: 797
References: 161
Citations by year: 2026: 195 · 2025: 236 · 2024: 214 · 2023: 118 · 2022: 32
FWCI: 31.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords: epicardial adipose tissue, coronary artery disease, atrial fibrillation, heart failure, brown fat thermogenesis, inflammatory cytokines, profibrotic cytokines, GLP-1 receptor agonists, SGLT2 inhibitors, cardiovascular risk factors
MeSH terms: COVID-19, Adipose Tissue, Atrial Fibrillation, Cardiology, Humans, Pericardium

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Epicardial adipose tissue in contemporary cardiology

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