The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Nuclease resistance of DNA nanostructures
Open accessAbstract
DNA nanotechnology has progressed from proof-of-concept demonstrations of structural design towards application-oriented research. As a natural material with excellent self-assembling properties, DNA is an indomitable choice for various biological applications, including biosensing, cell modulation, bioimaging and drug delivery. However, a major impediment to the use of DNA nanostructures in biological applications is their susceptibility to attack by nucleases present in the physiological environment. Although several DNA nanostructures show enhanced resistance to nuclease attack compared with duplexes and plasmid DNA, this may be inadequate for practical application. Recently, several strategies have been developed to increase the nuclease resistance of DNA nanostructures while retaining their functions, and the stability of various DNA nanostructures has been studied in biological fluids, such as serum, urine and cell lysates. This Review discusses the approaches used to modulate nuclease resistance in DNA nanostructures and provides an overview of the techniques employed to evaluate resistance to degradation and quantify stability. DNA nanostructures are increasingly used in biological applications, in which nuclease resistance is a key parameter. This Review discusses the different strategies used to modulate and evaluate the nuclease resistance of DNA nanostructures.
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Cites
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,354
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
Seeman, N. C. (2003) · Nature · doi:10.1038/nature01406 · Cited by 2,782
DNA Topoisomerases: Structure, Function, and Mechanism
Champoux, J. J. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.369 · Cited by 2,743
Nucleic acid junctions and lattices
Seeman, N. C. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90002-9 · Cited by 2,497
A DNA-fuelled molecular machine made of DNA
Yurke, B., Turberfield, A. J., Mills, A. P., Simmel, F. C., & Neumann, J. L. (2000) · Nature · doi:10.1038/35020524 · Cited by 2,448
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,180
Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912
Seeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,627
Metadata
- Authors
- Chandrasekaran, A. R.
- Venue
- Nature Reviews Chemistry
- Published
- 2021-02-10
- Volume
- 5
- Issue
- 4
- Pages
- 225-239
- ISSN
- 2397-3358 (ISSN-L)
- OpenAlex
- W3126424583
- Cited by
- 382
- References
- 135
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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